Reepithelialization of a Full-Thickness Burn from Stem Cells of Hair Follicles Micrografted into a Tissue-Engineered Dermal Template (Integra)

Navsaria, Harshad; Ojeh, Nkemcho; Moiemen, Naiem; Griffiths, Matthew; Frame, James D.

doi:10.1097/01.prs.0000105632.86651.ef

Cited by 85 publications

(52 citation statements)

References 8 publications

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“…Several studies have unambiguously identified the hair follicle as a major reserve of adult stem cells (15,16). Dermal grafts from the scalp (10), early implantation of microdissected hair follicles through a silicone epidermis (11) and hair grafting (17) are used for cutaneous wound repair; however, the procedures are complicated. In the present study, hair follicles without epidermal or interfollicular tissue were transplanted.…”

Section: Discussionmentioning

confidence: 99%

“…The scalp has been identified as an excellent donor site for thin skin grafts (9); however, the scalp dermal graft presents a limited surface area and is <3-4% of the total body surface area (10). Clinical and histological evidence has shown that the rapid healing of the scalp dermal graft is attributed to the differential potential of the cells in the hair follicles, and that re-epithelialization can also occur from grafted hair follicles (11). Numerous types of cells with multiple differentiation potentials have been identified in hair follicles, and their relative contribution to re-epithelialization has been recently determined (12).…”

Section: Introductionmentioning

confidence: 99%

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Hair follicle units promote re-epithelialization in chronic cutaneous wounds: A clinical case series study

Liu

Zhao

2015

Experimental and Therapeutic Medicine

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Abstract. Chronic cutaneous wounds are one of the most unfavorable pathophysiological processes in routine practice. However, developments in hair follicle unit therapy may aid the treatment of these wounds. The aim of the present study was to investigate the function of hair follicle units in chronic cutaneous wound re-epithelialization and to develop an effective protocol for wound treatment. A total of 14 patients, of which nine were male and five were female, with a mean age of 60.71 years (range, 19-76 years) and a mean wound area of 74.14 cm 2 , were treated in the study. The hair follicle units were dissected from a scalp graft and transplanted into the chronic cutaneous wound bed, after which clinical evaluation was performed. Images of the recipient site were captured at 0, 1, 2, 3, 4, 5, 8 and 14 weeks following transplantation. In addition, histological examinations were conducted postoperatively at week 16. Total wound re-epithelialization was observed in all the patients. Histological analysis revealed that the epidermis and papillary dermis were present in the wound area. Adnexal structures and the reticular dermis were also observed. Therefore, the present study demonstrated the ability of hair follicle units to promote chronic cutaneous wound healing.

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Section: Discussionmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

Hair follicle units promote re-epithelialization in chronic cutaneous wounds: A clinical case series study

Liu

Zhao

2015

Experimental and Therapeutic Medicine

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“…Human ectodermal stem cells from micro-grafted hair follicles have been used clinically to repopulate a dermal template for burned skin replacement. 37 Another example of ectodermal stem cell engineering is rat neural stem and progenitor cells differentiating into functional neuronal circuits in a 3D collagen gel, with the potential to repair injury to the central nervous system. 38 Endodermal stem cells differentiate into many of the internal organs, such as the liver, lung, and pancreas, and have been used, for example, to generate b-like cell colonies that increase insulin secretion in response to glucose.…”

Section: Tissue Locationmentioning

confidence: 99%

Review:Ex VivoEngineering of Living Tissues with Adult Stem Cells

et al. 2006

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Adult stem cells have the potential to revolutionize regenerative medicine with their unique abilities to self-renew and differentiate into various phenotypes. This review examines progress and challenges in ex vivo tissue engineering with adult stem cells. These rare cells are harvested from a variety of tissues, including bone marrow, adipose, skeletal muscle, and placenta, and differentiate into cells of their own lineage and in some cases atypical lineages. Insight into the stem cell niche leads to the identification of matrix components, soluble factors, and physiological conditions that enhance the ex vivo amplification and differentiation of stem cells. Scaffolds composed of metals, naturally occurring materials, and synthetic polymers organize stem cells into complex spatial groupings that mimic native tissue. Cell signals from covalently bound ligands and slowly released regulatory factors in scaffolds direct stem cell fate. Future advances in stem cell biology and scaffold design will ultimately improve the efficacy of tissue substitutes as implants, in research, and as extracorporeal devices.

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“…Existen informes de casos de reconstrucción de cuero cabelludo con Integra® y luego implantes a base de microdisecciones de folículos pilosos a través de la lámina de silicona, resultando una reepitelización completa y un cuero cabelludo con cabello sin necesidad de un injerto de piel parcial. Se logró de esta manera la restauración de la población de células troncales, crecimiento del cabello y reepitelización temprana a través de esta nueva técnica de microinjertos (12).…”

Section: Discussionunclassified

Experiencia en el tratamiento de quemaduras de cuero cabelludo

Pereira

Léniz

Enríquez

et al. 2013

Cir. plást. iberolatinoam.

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ResumenEl cuero cabelludo es la barrera más externa y más importante del cráneo y del cerebro. Si bien las quemaduras de esta zona son raras, cuando se producen suelen estar causadas por alta tensión eléctrica, fuego, líquidos hirvientes u otras fuentes de calor.El objetivo de este trabajo es presentar una serie de casos de quemaduras de cuero cabelludo tratadas en los últimos 10 años en el Hospital del Trabajador de Santiago (Chile). Se trata de un estudio descriptivo retrospectivo en el que se analizó la información demográfica y terapéutica de los pacientes que requirieron hospitalización al tiempo que se revisó la literatura al respecto.En total se registraron 2.266 consultas por quemaduras en la cabeza, de las cuales 34 fueron del cuero cabelludo y 11 requirieron hospitalización; la mayoría fueron quemaduras eléctricas, 4 casos y por fuego, otros 4 casos. En el tratamiento, destacó el uso en 1 caso de colgajo libre asociado a colgajos locales de avance. En el tratamiento de las secuelas se utilizaron expansores y posteriormente colgajos locales de avance.Sólo una pequeña parte de los pacientes que consultan por quemaduras en la cabeza corresponden a quemaduras del cuero cabelludo. La mayoría son tratadas de forma ambulatoria y no requieren acciones mayores. Los pacientes con quemaduras eléctricas suelen requerir tratamientos más agresivos. Para el tratamiento de las secuelas son preferibles los expansores y los colgajos de avance. Palabras clave Quemaduras de cuero cabelludo,Expansores, Colgajos locales de avance. Código numérico 2030-2033-15831 AbstractThe scalp is the most external and important barrier of the skull and brain. Burns in this area are rare, but often caused by high voltage injuries, fire, liquid or other heat sources.The aim of this paper is to present a series of cases of scalp burns of the last 10 years in the Hospital del Trabajador de Santiago (Chile). This is a retrospective and descriptive study. We analyzed the demography and treatment of patients requiring hospitalization and we reviewed the literature.There were 2.266 visits for head burns, of which 34 patients consulted with scalp burns, 11 of them were hospitalized. Most were due to electrical burns, 4 patients, and fire, 4 patients. In the treatment, highlighted the use in a case of free flap and local advancement flaps. In the management of sequelae, expanders and then local advancement flaps were performed.Only a small proportion of patients attending with head burns had scalp burns. Most were treated on as outpatient and did not require further action. The group of patients with electrical burns required more aggressive treatments while the management of the sequelaes is done with expanders and local advancement flaps.

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Reepithelialization of a Full-Thickness Burn from Stem Cells of Hair Follicles Micrografted into a Tissue-Engineered Dermal Template (Integra)

Cited by 85 publications

References 8 publications

Hair follicle units promote re-epithelialization in chronic cutaneous wounds: A clinical case series study

Hair follicle units promote re-epithelialization in chronic cutaneous wounds: A clinical case series study

Review:Ex VivoEngineering of Living Tissues with Adult Stem Cells

Experiencia en el tratamiento de quemaduras de cuero cabelludo

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