Review:<i>Ex Vivo</i>Engineering of Living Tissues with Adult Stem Cells

Barrilleaux, Bonnie L.; Phinney, Donald G.; Prockop, Darwin J.; O’Connor, Kim C.

doi:10.1089/ten.2006.12.3007

Cited by 200 publications

(103 citation statements)

References 128 publications

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“…[27][28][29][30][31] In practice, most bone tissue engineering approaches implement a combination of these strategies. However, two primary tissue engineering strategies have emerged as the most promising approaches.…”

Section: General Principles In Bone Tissue Engineeringmentioning

confidence: 99%

Bone tissue engineering: A review in bone biomimetics and drug delivery strategies

Porter

Ruckh

Popat

2009

Biotechnology Progress

685

499

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Critical‐sized defects in bone, whether induced by primary tumor resection, trauma, or selective surgery have in many cases presented insurmountable challenges to the current gold standard treatment for bone repair. The primary purpose of a tissue‐engineered scaffold is to use engineering principles to incite and promote the natural healing process of bone which does not occur in critical‐sized defects. A synthetic bone scaffold must be biocompatible, biodegradable to allow native tissue integration, and mimic the multidimensional hierarchical structure of native bone. In addition to being physically and chemically biomimetic, an ideal scaffold is capable of eluting bioactive molecules (e.g., BMPs, TGF‐βs, etc., to accelerate extracellular matrix production and tissue integration) or drugs (e.g., antibiotics, cisplatin, etc., to prevent undesired biological response such as sepsis or cancer recurrence) in a temporally and spatially controlled manner. Various biomaterials including ceramics, metals, polymers, and composites have been investigated for their potential as bone scaffold materials. However, due to their tunable physiochemical properties, biocompatibility, and controllable biodegradability, polymers have emerged as the principal material in bone tissue engineering. This article briefly reviews the physiological and anatomical characteristics of native bone, describes key technologies in mimicking the physical and chemical environment of bone using synthetic materials, and provides an overview of local drug delivery as it pertains to bone tissue engineering is included. © 2009 American Institute of Chemical Engineers Biotechnol. Prog., 2009

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Section: General Principles In Bone Tissue Engineeringmentioning

confidence: 99%

Bone tissue engineering: A review in bone biomimetics and drug delivery strategies

Porter

Ruckh

Popat

2009

Biotechnology Progress

685

499

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“…These cells are lineage-restricted and are recognized by its tissue origin type i.e., mesenchymal stem cell, adipose-derived stem cell, endothelial stem cell and dental pulp stem cell [41,42]. More specifically, human pluripotent stem cells (PSCs) offer enormous opportunities for regenerative medicine [40] and other biological applications [4].…”

Section: Pluripotent Stem Cellsmentioning

confidence: 99%

Role of regeneration in tissue repairing and therapies

Upadhyay¹

2015

J Regen Med Tissue Eng

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Present review article emphasizes role of regeneration mechanism in various tissues and its use in organ transplantation for wound healing and repairing. This article also explains uses of various stem cell types in transplantation technologies and its applications in regenerative medicine and therapeutics. This review also addresses tissue engineering methods and use of new biological scaffold materials and promising candidates such as immunomodulators, adhesions, integrins in tissue repairing and induction of regeneration in injured tissues. In addition, role of various molecules of immune cell system, gene cascades and transcription specific proteins (TSPs) and growth factors in formation of microenvironment for differentiation are also explained. Moreover, mechanism of regeneration in various tissues such as neural, skeletal, cardiac, muscular, adipose and gonadial tissues, and bone marrow is described in detail. This article also suggest an urgent need for development of new advanced methods, technologies, biomatrices, polymers and scaffold materials, and cell based therapies to overcome the problem of disable and injured patients. Hence, landmark innovations are required in the field of regenerative medicine, tissue engineering, and developmental biology for successful tissue repairing and organ transplants to serve the human society.

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“…Studies of cell populations from different patients indicate common expression patterns of surface antigens, such as CD44, CD71, CD90 and CD105, with low expression levels of hematopoetic and endothelial lineage markers [19,20]. As there is no definitive set of markers that identify a stem cell, the differentiation potential is commonly determined using in vitro differentiation models.…”

Section: Cell Sourcesmentioning

confidence: 99%

Engineering custom-designed osteochondral tissue grafts

Grayson

Chao

Marolt

et al. 2008

Trends in Biotechnology

125

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Tissue engineering is expected to help us outlive the failure of our organs by enabling the creation of tissue substitutes capable of fully restoring the original tissue function. Degenerative joint disease, which affects one-fifth of the US population and is the country's leading cause of disability, drives current research of actively growing, functional tissue grafts for joint repair. Toward this goal, living cells are used in conjunction with bio-material scaffolds (serving as instructive templates for tissue development) and bioreactors (providing environmental control and molecular and physical regulatory signals). In this review, we discuss the requirements for engineering customized, anatomically-shaped, stratified grafts for joint repair and the challenges of designing these grafts to provide immediate functionality (load bearing, structural support) and long-term regeneration (maturation, integration, remodeling).

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Review:Ex VivoEngineering of Living Tissues with Adult Stem Cells

Cited by 200 publications

References 128 publications

Bone tissue engineering: A review in bone biomimetics and drug delivery strategies

Bone tissue engineering: A review in bone biomimetics and drug delivery strategies

Role of regeneration in tissue repairing and therapies

Engineering custom-designed osteochondral tissue grafts

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