Reexpression of morphine-induced oral stereotypy six months after last morphine sensitizing dose

Pollock, Jondavid; Kornetsky, Conan

doi:10.1016/0091-3057(95)00199-9

Cited by 26 publications

(5 citation statements)

References 12 publications

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“…At this point, rats typically filled their mouths with bedding granules and started chewing. During week 2 of exposure, rats began to display oral stereotypy (gentle forelimb chewing) and hyperactivity, consistent with other reports of rat responses to chronic opioid exposure 44–46 . This hyperactivity included short bursts of rapid locomotion from one side of the cage to the other (along the cage’s length), lasting up to 3 hours post-exposure.…”

Section: Resultssupporting

confidence: 87%

Divergent profiles of fentanyl withdrawal and associated pain in mice and rats

Uddin

Jenne

Fox

et al. 2020

Preprint

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Opioid abuse has devastating effects on patients, their families, and society. Withdrawal symptoms are severely unpleasant, prolonged, and frequently hinder recovery or lead to relapse. The sharp increase in abuse and overdoses arising from the illicit use of potent and rapidly-acting synthetic opioids, such as fentanyl, highlights the urgency of understanding the withdrawal mechanisms related to these drugs. Progress is impeded by inconsistent reports on opioid withdrawal in different preclinical models. Here, using rats and mice of both sexes, we quantified withdrawal behaviors during spontaneous and naloxone-precipitated withdrawal, following two weeks of intermittent fentanyl exposure. We found that both mice and rats lost weight during exposure and showed increased signs of distress during spontaneous and naloxone precipitated withdrawal. However, these species differed in their expression of withdrawal associated pain, a key contributor to relapse in humans. Spontaneous or ongoing pain was preferentially expressed in rats in both withdrawal conditions, while no change was observed in mice. In contrast, withdrawal associated thermal hyperalgesia was found only in mice. These data suggest that rats and mice diverge in how they experience withdrawal and which aspects of the human condition they most accurately model. These differences highlight each species’ strengths as model systems and can inform experimental design in studies of opioid withdrawal.

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Section: Resultssupporting

confidence: 87%

Divergent profiles of fentanyl withdrawal and associated pain in mice and rats

Uddin

Jenne

Fox

et al. 2020

Preprint

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“…Enkephalin analogues are known stimulants of motor behaviour (Stinus et al ., 1980; Kalivas et al ., 1983). Morphine sensitization produces oral stereotypies (Pollock & Kornetsky, 1996) and endomorphin‐1 injected into the globus pallidus induces orofacial dyskinesias in rats (Mehta et al ., 2001), behaviours similar to those observed in the context of BDV infection.…”

Section: Resultsmentioning

confidence: 99%

Key role for enkephalinergic tone in cortico–striatal–thalamic function

Solbrig

Koob

Lipkin

2002

Eur J of Neuroscience

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Whereas the role of dopaminergic tone in the cortico-striatal-thalamic system is well-established, the role of endogenous opioids in the function of this system is less understood. We show that Borna disease virus infection of adult rats results in an increase in preproenkephalin transcripts in the striatum of Borna-infected rats, a region important for forming coordinated sequential motor actions and in developing programmes of thought and motivation. Stereotypic behaviours and dyskinesias, the clinical hallmarks of infection in adult Lewis rats (BD rats), are accompanied by a disrupted pattern of immediate early gene c-fos activation in the motor thalamus, with significance for the breakdown in coordinated sequential motor actions. We also find increased preproenkephalin in infected cultured neuroblastoma and rat foetal glial cells. The expression pattern of enkephalin mRNA in vivo and in vitro suggest that increased enkephalin function is one of the neuropharmacological means by which Borna disease virus causes motor disease of animals and possibly cognitive and affective disease in man, and further suggest that enkephalins play a critical role in the maintenance of a balanced tone of activity in the cortico-basal ganglia-thalamo-cortical loops.

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“…In the present study we evaluated the effects of morphine sensitization on the behavioural responses of rats. According to previous investigations, µ‐opioid receptor agonists such as morphine are strongly involved in the mediation of locomotor activity, 30,31 oral stereotypy 32,33 and state‐dependent memory, as in the passive avoidance test 34,35 . Morphine sensitization has been shown to intensify these behavioural responses 36–38 .…”

Section: Discussionmentioning

confidence: 98%

DECREASED AMPA GLuR2, BUT NOT GLuR3, mRNA EXPRESSION IN RAT AMYGDALA AND DORSAL HIPPOCAMPUS FOLLOWING MORPHINE‐INDUCED BEHAVIOURAL SENSITIZATION

Sepehrizadeh

Shapourabadi

Ahmadi

et al. 2008

Clin Exp Pharma Physio

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1. Repeated administration of psychostimulants and micro-opioid receptor agonists elicits a progressive enhancement of drug-induced behavioural responses, a phenomenon termed behavioural sensitization. These changes in behaviour may reflect plastic changes requiring regulation of alpha-amino-3-hydroxy-5-methyl-4-isoxazole proprionic acid (AMPA) receptor function. 2. In the present study, rats were treated for 7 days with saline or morphine (10 mg/kg). After a washout period of either 24 h or 7 days, locomotion, oral stereotypy and state-dependent memory in a passive avoidance test were measured in the presence or absence of 6-cyano-7-nitroquinoxaline-2,3-dione disodium salt (CNQX; 3 mg/kg), an AMPA receptor antagonist. In order to evaluate the mechanism underlying the behavioural responses, quantitative real-time reverse transcription-polymerase chain reaction was used to evaluate mRNA expression of the AMPA receptor subunits GluR2 and GluR3 in the striatum, prefrontal cortex, hippocampus, hypothalamus and amygdala of animals treated repeatedly with morphine. 3. The results indicate that repeated morphine treatment followed by 7 days (but not 24 h) washout produces behavioural sensitization, as determined by locomotion, oral stereotypy and state-dependent memory. Blockade of AMPA receptors with CNQX on the test day did not alter these behavioural responses. In addition, repeated morphine treatment followed by 7 days (but not 24 h) washout decreased GluR2 mRNA expression in both the amygdala (by 50%) and hippocampus (by 35%). Repeated morphine treatment did not alter GluR3 mRNA expression in any brain area assessed. 4. These data imply that AMPA receptors are involved in the development (but not expression) phase of behavioural sensitization. The decreases in GluR2 mRNA expression in the amygdala and hippocampus may result in the formation of calcium-permeable AMPA receptors, which are believed to play an important role in behavioural sensitization.

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Reexpression of morphine-induced oral stereotypy six months after last morphine sensitizing dose

Cited by 26 publications

References 12 publications

Divergent profiles of fentanyl withdrawal and associated pain in mice and rats

Divergent profiles of fentanyl withdrawal and associated pain in mice and rats

Key role for enkephalinergic tone in cortico–striatal–thalamic function

DECREASED AMPA GLuR2, BUT NOT GLuR3, mRNA EXPRESSION IN RAT AMYGDALA AND DORSAL HIPPOCAMPUS FOLLOWING MORPHINE‐INDUCED BEHAVIOURAL SENSITIZATION

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