Reference database of biochemical markers of bone turnover for the Japanese female population. Japanese Population-based Osteoporosis (JPOS) Study

Iki, Masayuki; Akiba, Takashi; Matsumoto, Toshio; Nishino, Harumi; Kagamimori, Sadanobu; Kagawa, Yoshiko; Yoneshima, Hideo

doi:10.1007/s00198-004-1634-1

Cited by 82 publications

(54 citation statements)

References 48 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…The deficiencies of calcium and phosphorus in osteoporotic women lower the formation of the hydroxyapatite crystals, which make the free osteocalcin to circulate in the blood. This may explain the increased concentrations of osteocalcin in the sera of osteoporotic post menopausal women [8].…”

Section: Discussionmentioning

confidence: 99%

The Association of Serum Osteocalcin with the Bone Mineral Density in Post Menopausal Women

Ramesh²,

Venkatesan³

2013

JCDR

View full text Add to dashboard Cite

Background: The markers of bone remodelling, such as serum osteocalcin, may be used to assess osteoporosis and to predict the fracture risk in elderly persons, especially in women. The bone mineral density which reflects the bone mass and strength, also predicts osteoporotic related hip fractures. So, this work highlights the association between the bone turnover and the bone mass and strength. Aim:To assess the association between the biochemical markers of bone remodeling and osteocalcin with the bone mineral density in non osteoporotic and osteoporotic women among post menopausal subjects. Materials and Methods:Sixty postmenopausal women whose ages ranged from 55-65 years included in this study, were further divided into group 1 (thirty non osteoporotic subjects) and group 2 (thirty osteoporotic subjects). For all the subjects, serum osteocalcin was measured by ELISA. BMD was measured by the Dual Energy X-Ray Absorptiometry (DXA) scan.The women with osteoporosis were diagnosed, based on the T-score of the bone mineral density, by the DXA scan. The Student's "t" test was performed between the variables of both the groups and a correlation test was also performed between osteocalcin and BMD by using SPSS.Results: A negative correlation was found between the osteocalcin level and the bone mineral density in post menopausal women. The mean values of both serum osteocalcin and BMD between the osteoporotic and the non osteoporotic subjects were statistically significant. Conclusion:An increased bone turnover coincides with the trabecular deterioration in osteoporotic women of the post menopausal age group. A combination of biochemical markers and BMD may be a better predictor of the fracture risk than when it was assessed by either alone. The biochemical markers of the bone turnover cannot be a substitute for the serial BMD measurement, but they may be useful when they are considered in conjunction with the BMD measurement.KalaiSelvi vS, Prabhu K, Mani raMeSh, vathSala venKateSan InTROduCTIOnAccording to the WHO , osteoporosis is a disease which is characterized by a low bone mass and a microarchitectural deterioration of the bone tissue, which lead to an enhanced bone fragility and a consequent increase in the fracture sites. There are two forms of osteoporosis, based on whether the disease is primary or secondary to other identifiable medical conditions or treatment. Primary osteoporosis can be classified into two types, based on the uncoupling defects which are seen in the remodeling unit. Type 1 (postmenopausal) osteoporosis is caused by an acceleration in the bone turnover as a result of hormonal deprivation. Although the entire remodeling unit is activated by oestrogen deprivation, the bone resorption exceeds the bone formation because of the time constraints on the osteoblastic activity, ultimately resulting in bone loss. In type 2 or senile osteoporosis, the osteoblastic activity for forming new bone is impaired, even though the resorption is either normal or enhanced, resulting in a chronic imbalan...

show abstract

Section: Discussionmentioning

confidence: 99%

The Association of Serum Osteocalcin with the Bone Mineral Density in Post Menopausal Women

Ramesh²,

Venkatesan³

2013

JCDR

View full text Add to dashboard Cite

show abstract

“…Fewer menstrual dysfunctions in the sport dance subgroup are probably due to lower intensity of the training burden, which also conforms to a lower competition ranking of these interviewees. Previous researches docu men ted the influence of hypoes tro genism on the increase of the level of bone resorption markers, reduction of BMD and the consequential occurrence of osteo po rosis in postmenopausal women (22)(23)(24). However, very few researches have targeted the dynamics of bone metabolism markers in sports women with menstrual dysfunctions or secon dary osteoporosis (25)(26)(27)(28).…”

Section: Discussionmentioning

confidence: 99%

Bone Metabolism Markers in Sportswomen with Menstrual Cycle Dysfunctions

Ponorac¹,

Rašeta²,

Radovanović³

et al. 2011

Journal of Medical Biochemistry

View full text Add to dashboard Cite

Kratak sadr`aj: Dobro je poznata ~injenica da su sport ist kinje sa neredovnim menstrualnim ciklusom izlo`ene riziku od smanjenja ko{tane mineralne gustine i posledi~no osteoporozi. Pra}enje nivoa biohemijskih markera ko {tanog metabolizma omogu}ava razumevanje dina m i ~kih promena tokom procesa remodeliranja kosti. Ciljevi spro vedenog istra`ivanja bili su: utvrditi prevalence men stru alnih poreme}aja na uzorku sportistkinja i kontrolne grupe, kao i odrediti nivoe markera ko{tanog metabolizma u grupama ispitanica sa menstrualnim disfunkcijama. Ispi tanice (n=117) bile su podeljene u dve grupe, ekspe rimentalnu (S) (n=84) podeljenu u tri podgrupe (34 sportistkinje igara sa loptom, 27 atleti~arki i 23 takmi~arke u sportskom plesu) i kontrolnu grupu (C) (n=34). Za odre|ivanje menstrualnog profila i poreme}aja menstrual nog ciklusa kori{}en je upitnik. Odre|en je nivo srednjeg fragmenta osteokalcina (N-MID osteokalcin) kao markera formiranja kosti i b-CrossLaps (b-CTx -marker resorpcije kosti) elektroluminiscentnom imunohemijskom metodom na automatskom aparatu Elecsys 1010. Primarna ame noreja na|ena je kod 7 (8,33%) a oligomenoreja kod 11 (13,09%) sportistkinja, {to je statisti~ki zna~ajno vi{a incidenca u odnosu na kontrolnu grupu. Vrednosti markera ko{tanog metabo lizma su pokazale statisti~ki zna~ajnu razliku u nivou mar ke ra resorpcije kosti, b-CrossLaps, izme|u grupa ameno rei~ nih i oligomenorei~nih sportistkinja u odnosu na eume no rei ~ne ispitanice, kako sportistkinje tako i kontrolnu grupu. Ubrzanu resorpciju je pratilo i ubrzano formiranje kosti (pove}ane Summary: It is a well known fact that sportswomen with irregular menstrual cycle are exposed to the risk of dimi nished bone mineral density, and consequentially osteoporosis may appear. Monitoring of the levels of biochemical markers of bone metabolism enables understanding of the dynamic changes during the bone remodeling process. The objectives of the conducted research were to determine the prevalence of menstrual dysfunctions in a sportswomen sample and a control group, and also to determine the levels of bone metabolism markers in groups of women with menstrual dysfunctions. The women (n=117) were separated into two groups, the experi men tal group (S) (n=84) comprised of three subgroups of sports women (34 women who play ball game sports, 27 athletes and 23 sport dancers) and the control group (C) (n=34). To establish the menstrual profile and dys function of the menstrual cycle, we used a very detailed questionnaire. The level of mid-fragment osteo calcin (N-MID osteocalcin) as a mar ker of bone forma tion was deter mined, as well as b-Cross Laps (bCTx-bone resorption marker) via the electro luminescent immunoche mistry method on an Elecsys 1010 automated machine. Pri mary amenorrhea was found in 7 (8.33%) and oligome norrhea in 11 (13.09%) sportswomen, which was statistically a much higher incidence (p<0.05) than in the control group (0/34). Values of bone metabolism markers showed a sta tistically significant difference in the level of the...

show abstract

“…This study similarly divided subjects into 2 groups at age 50, and a significant relationship was noted between age (50 years or older) and osteopenia [19]. Causes may include reduced osteoblast function and calcium absorption due to aging [34,35]. …”

Section: Discussionmentioning

confidence: 99%

Decrease of Estradiol and Several Lifestyle Factors, but Not <b><i>Helicobacter pylori</i></b> Infection, Are Significant Risks for Osteopenia in Japanese Females

Chinda

Shimoyama²,

Takikawa³

et al. 2017

Digestion

View full text Add to dashboard Cite

Background: The primary cause of osteoporosis in women is increased bone resorption and decreased bone density associated with reduced estrogen secretion. Several studies have demonstrated a relationship between Helicobacter pylori infection and osteoporosis regardless of estrogen levels. This study examined the relationship between H. pylori infection and osteopenia together with estrogen levels, calcium intake, and several lifestyle factors. Methods: This study included 473 healthy women who underwent a general health examination. Multivariate analysis was performed, with age, body mass index (BMI), smoking habit, drinking habit, exercise habit, schooling duration, estradiol levels, birth history, calcium intake, schooling duration, smoking habit, drinking habit, exercise habit, and H. pylori infection as independent variables and the presence of osteopenia as a dependent variable. Results: The adjusted OR for osteopenia with H. pylori infection was 0.95 (95% CI 0.55-1.63, p = 0.84). In contrast, osteopenia was significantly associated with age, low BMI, lesser schooling period, low estradiol levels, and low calcium intake. Conclusions:H. pylori infection was not a significant risk for osteopenia by the multivariate analysis, which included the primary confounding factors. Significant factors, such as estradiol and calcium intake, should be assessed together to study the association of H. pylori infection and osteopenia.

show abstract

Reference database of biochemical markers of bone turnover for the Japanese female population. Japanese Population-based Osteoporosis (JPOS) Study

Cited by 82 publications

References 48 publications

The Association of Serum Osteocalcin with the Bone Mineral Density in Post Menopausal Women

The Association of Serum Osteocalcin with the Bone Mineral Density in Post Menopausal Women

Bone Metabolism Markers in Sportswomen with Menstrual Cycle Dysfunctions

Decrease of Estradiol and Several Lifestyle Factors, but Not <b><i>Helicobacter pylori</i></b> Infection, Are Significant Risks for Osteopenia in Japanese Females

Contact Info

Product

Resources

About