Reference equations for spirometry in healthy Asian children aged 5 to 18 years in Taiwan

Chang, Sheng Mao; Tsai, Hui Ju; Tzeng, Jung Ying; Yeh, Kuo Wei; Chen, Li Chen; Lai, Siang Hui; Liao, Sui‐Ling; Hua, Man Chin; Tsai, Ming Han; Huang, Jing‐Long; Yao, Tsung Chieh

doi:10.1016/j.waojou.2019.100074

Cited by 32 publications

(37 citation statements)

References 37 publications

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“…For female subjects, the same pattern is found except for adolescent subjects in whom this ratio was similar. It is commonly believed that the FEV1/FVC ratio varies little between ethnic groups [ 8 ] but some studies report significantly higher FEV1/FVC values in blacks living in Africa and in Asian groups [ 10 , 21 , 23 , 24 ]. This variability of the FEV1/FVC ratio can be explained by a non-proportional variation of FEV1 and FVC in the different ethnic groups.…”

Section: Discussionmentioning

confidence: 99%

Spirometric reference equations for Cameroonians aged 4 to 89 years derived using lambda, mu, sigma (LMS) method

et al. 2021

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Background Spirometric reference values are well known in several ethnic groups but the normative spirometric values of blacks living in Africa have been less studied. The purpose of this study is to establish normative spirometric equations from a representative population of Cameroonian children and adults and compare these equations with those developed by the Global Lung Initiative (GLI) and in Nigerians. Methods Spirometric data from healthy Cameroonians aged 4–89 years randomly collected between 2014 and 2018 were used to derive reference equations using generalized additive model for location (mu), shape (lambda) and scale (sigma). Results A total of 625 children and adolescents (290 males and 335 females) and 1152 adults (552 males and 600 females) were included in the study. The prediction equation for spirometric index was written as: M = Exp[a0 + a1*ln (Height) + a2*ln (Age) + Mspline, Mspline was age related spline contribution]. Applying the GLI standards for African Americans resulted in overall values greater than those found in our study for forced expiratory volume in 1s (FEV1) and forced vital capacity (FVC). These values were very close in children and adolescents while the values obtained with the GLI equations for African Americans were significantly higher in adults. FEV1/FVC ratio in our study was similar for adult males but lower in adult females (88% vs 85%, difference = + 3.5%) when applying Nigerian standards. Conclusions FEV1 and FVC of the Cameroonian infant and adolescent population are very close to those of black Americans. However, FEV1 and FVC of Cameroonian adults are significantly lower than those of black American adults. These equations should allow a more suitable interpretation of spirometry in the Cameroonian population.

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Section: Discussionmentioning

confidence: 99%

Spirometric reference equations for Cameroonians aged 4 to 89 years derived using lambda, mu, sigma (LMS) method

et al. 2021

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“…For female subjects, the same pattern is found except for adolescent subjects in whom this ratio was similar. It is commonly believed that the FEV1/FVC ratio varies little between ethnic groups [8] but some studies report signi cantly higher FEV1/FVC values in blacks living in Africa and in Asians groups [10,21,23,24]. This variability of the FEV1/FVC ratio can be explained by a non-proportional variation of FEV1 and FVC in the different ethnic groups.…”

Section: Discussionmentioning

confidence: 99%

Spirometric Reference Equations For Cameroonians Aged 4 To 89 Years Derived Using Lambda, Mu, Sigma (LMS) Method

Pefura-Yone

Balkisssou

Poka-Mayap

et al. 2021

Preprint

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Background: Spirometric reference values are well known in several ethnic groups but the normative spirometric values of blacks living in Africa have been less studied. The purpose of this study is to establish normative spirometric equations from a representative population of Cameroonian children and adults and compare these equations with those developed by Global Lung Initiative (GLI) and in Nigerians.Methods: Spirometric data from healthy Cameroonians aged 4 to 89 years randomly collected between 2014 and 2018 were used to derive reference equations using generalized additive model for location (mu), shape (lambda) and scale (sigma).Results: A total of 625 children and adolescents (290 males and 335 females) and 1152 adults (552 males and 600 females) were included in the study. The prediction equation for any spirometric index was written as: M = Exp[a0 + a1*ln (Height) + a2*ln (Age) + Mspline, Mspline was age related spline contribution]. Applying the GLI standards for African Americans results in overall values greater than those found in our study for forced expiratory volume in 1 s (FEV1) and forced vital capacity (FVC). These values were very close in children and adolescents while the values obtained with the GLI equations for African Americans were significantly higher in adults. FEV1/FVC ratio in our study was similar for adult males but lower in adult females (88% vs 85%, difference = + 3.5%) when applying Nigerian standards. Conclusions: FEV1 and FVC of the Cameroonian population are very close to those of black American children and adolescents. However, FEV1 and FVC of Cameroonian adults are significantly lower than those of black American adults. These equations should allow a more suitable interpretation of spirometry in the Cameroonian population.

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“…1 . Study participants were recruited from a population-based cohort of 5351 children (2616 boys, 48.9%; age, 10.4 ± 2.9 years), participating in the Prediction of Allergies in Taiwanese CHildren (PATCH) study 3 , 19 – 24 . Among the subjects, 1900 children were randomly invited and 1717 of them agreed to participate the study.…”

Section: Methodsmentioning

confidence: 99%

Allergic diseases attributable to atopy in a population sample of Asian children

Huang

Pan³

et al. 2021

Sci Rep

Self Cite

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The proportion of allergic diseases attributable to atopy remains a subject of controversy. This study aimed to estimate the population risk of physician-diagnosed asthma, rhinitis and eczema attributed to atopy among a population sample of Asian school-age children. Asian children aged 5–18 years (n = 1321) in the Prediction of Allergies in Taiwanese CHildren (PATCH) study were tested for serum allergen-specific immunoglobulin E. Physician-diagnosed asthma, rhinitis and eczema were assessed by a modified International Study of Asthma and Allergies in Childhood questionnaire. Atopy was defined as the presence of serum allergen-specific immunoglobulin E. In this population-based study, 50.4% of the subjects with asthma, 46.3% with rhinitis, and 46.7% with eczema were attributable to atopy. The population attributable risk (PAR) of atopy for three allergic diseases was higher in adolescents (asthma, 54.4%; rhinitis, 59.6%; eczema, 49.5%) than younger children aged less than 10 years (asthma, 46.9%; rhinitis, 39.5%; eczema, 41.9%). Among the seven allergen categories, sensitization to mites had the highest PARs for all three allergic diseases (51.3 to 64.1%), followed by sensitization to foods (asthma, 7.1%; rhinitis, 10.4%; eczema 27.7%). In conclusion, approximately half (46.3 to 50.4%) of Asian children in Taiwan with allergic diseases are attributable to atopy.

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Reference equations for spirometry in healthy Asian children aged 5 to 18 years in Taiwan

Cited by 32 publications

References 37 publications

Spirometric reference equations for Cameroonians aged 4 to 89 years derived using lambda, mu, sigma (LMS) method

Spirometric reference equations for Cameroonians aged 4 to 89 years derived using lambda, mu, sigma (LMS) method

Spirometric Reference Equations For Cameroonians Aged 4 To 89 Years Derived Using Lambda, Mu, Sigma (LMS) Method

Allergic diseases attributable to atopy in a population sample of Asian children

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