Reference intervals for thyroid‐stimulating hormone and thyroid hormones using the access TSH 3rd IS method in China

Li, Zhenzhen; Yu, Benzhang; Wang, Jiliang; Yang, Qin; Jia, Ming; Tang, Yurong

doi:10.1002/jcla.23197

Cited by 7 publications

(8 citation statements)

References 17 publications

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“…As the activity of 5'-deiodinase deiodinase found in young males was strong (15), it is not surprising that the levels of T3 and FT3 were higher in adolescent males (20-24 years old) since 5'-deiodinase is able to convert T4 to T3 (16). Regarding the level of T4, previous studies reported a higher level of T4 in males, which is in line with our study (17,18). The TSH level barely changed over age in males but increased steadily in females from the age of 40 to 68 years (Figure 2).…”

Section: Discussionsupporting

confidence: 92%

The reference intervals for thyroid hormones: A four year investigation in Chinese population

Xie

Feng

et al. 2023

Front. Endocrinol.

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IntroductionThe reference intervals (RIs) are of great importance for physicans to determine whether or not an individual is healthy. However, many clinical laboratories in China still adopted the default RI provided by the manufacturers; and these “uncalibrated” RIs might lead to the misdiagnosis of diseases. In the present study, we enroll reference people with the purpose of determining the RIs of serum triiodothyronine (T3), thyroxine (T4), free triiodothyronine (FT3), free thyroxine (FT4) and thyroid-stimulating hormone (TSH) in Chinese population, and explore the possible roles of age and sex on the levels of biomarkers.MethodsSerum samples from 66,609 individuals who met the inclusion criteria were analyzed using an Roche Cobas E 601 hormone analyzer. The dynamic trends of biomarker were visually assessed by their concentrations over age and sex. Specific partitions were determined by the method of Harris and Boyd. RIs, corresponding to the 2.5th and 97.5th percentiles, as well as the 0.5th, 25th, 50th, 75th and 99.5th percentiles were calculated for each reference partition using a non-parametric rank approach.ResultsThe serum level of T3, T4, FT4 or TSH showed a right-skewed distribution in both males and females while FT3 presented an approximate normal distribution. Females had a higher mode value of serum T3 or T4, but a lower mode value of serum TSH, FT3 or FT4. All five biomarkers did not need age partitioning according to the approach of harris and boyd, while T3 and FT3 need sex partitioning.ConclusionsThe present study not only determined the age- and sex-specific trends of the five thyroid hormones, but provided sex-stratified RIs for T3 and FT3, valuably contributing to the current literature and timely evaluation of thyroid health and disease.

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Section: Discussionsupporting

confidence: 92%

The reference intervals for thyroid hormones: A four year investigation in Chinese population

Xie

Feng

et al. 2023

Front. Endocrinol.

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“…Difference in the upper limits may be explained by the age composition of the population living at different altitudes in China, as in the case of the three regions of Tibet, where the proportion of people aged >65 years was only approximately 5% (32). Obvious discrepancies were observed for TSH, FT3, and FT4 levels between males and females, although the effect of sex on TSH level was not as remarkable as those on FT3 or FT4, which was consistent with previous studies (14,27,33,34). Thus, sexspecific RIs for FT4 and FT3, but not for TSH, were proposed in our study and results showed that both the upper and lower limits of RIs for FT3 and FT4 were higher in males than in females, which can be interpreted by the potential effect of sex hormones on the HPT axis (10,35).…”

Section: Discussionsupporting

confidence: 91%

Establishment of Reference Intervals for Thyroid-Associated Hormones Using refineR Algorithm in Chinese Population at High-Altitude Areas

Zhong

Zou

et al. 2022

Front. Endocrinol.

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ObjectivesDiagnosis of thyroid disease among individuals dwelling at high altitude remains a challenge. Reference intervals (RIs) for thyroid-associated hormones among Tibetans living at various high altitudes were established to improve diagnosis.MethodsOne thousand two hundred eighty-one subjects were randomly recruited from Nyingchi, Shigatse/Lhasa, and Ali of Tibet. Thyroid-stimulating hormone (TSH), free triiodothyronine (FT3), and free thyroxine (FT4) were measured by the Cobas e601 electrochemiluminescence analyzer. We used multiple linear regression and variance component analysis to assess the effect of sex, age, and altitude on hormones. RIs were established by refineR algorithm and compared with those provided by the manufacturer.ResultsSerum TSH was significantly lower in males than in females, while FT3 and FT4 were higher in males. Both FT3 and FT4 decreased with increasing age. FT3 increased with altitude, while TSH and FT4 were less influenced by altitude. The RI for TSH was 0.764–5.784 μIU/ml, while for FT4, the RIs were 12.36–19.38 pmol/L in females and 14.84–20.18 pmol/L in males. The RIs for FT3 at Nyingchi, Shigatse/Lhasa, and Ali in females were 4.09–4.98, 4.31–5.45, and 4.82–5.58 pmol/L, while in males, the values were 4.82–5.41, 4.88–5.95, and 5.26–6.06 pmol/L, respectively. The obtained RIs for TSH and FT4 were generally higher, while that for FT3 was narrower than the RIs provided by Cobas.ConclusionsSpecific RIs were established for thyroid-associated hormones among Tibetans, which were significantly different from those provided by the manufacturer.

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“…The significant differences in reference ranges between men and women were observed in Chinese population. 22 By contrast, in the study from Brasil, no gender-related differences in reference ranges were found. 23 This indicates the differences between populations and the necessity for determination of population-based reference intervals.…”

Section: Resultsmentioning

confidence: 67%

First Estimation of Reference Intervals for Thyroid-Stimulating Hormone and Thyroid Hormones in Slovenian Population

Oblak

Biček

Pirnat

et al. 2021

ACSi

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For thyroid function estimation and clinical decision making, use of appropriate reference intervals for thyroid-stimulating hormone (TSH), free thyroxine (fT4) and free triiodothyronine (fT3) is crucial. For each laboratory, establishment of own reference intervals is advised. For the first Slovenian estimation of reference intervals for thyroid hormones a large group of 1722 healthy individuals without thyroid disease was established retrospectively. Hormone analyses were performed on automated analyser Advia Centaur XP Immunoassay System (Siemens Healthineers), which reference intervals for TSH, fT4 and fT3 were 0.55–4.78 mIU/L, 11.5–22.7 pmol/L, and 3.5–6.5 pmol/L, respectively. Statistical analysis followed non-parametric percentile method. Our laboratory reference intervals for TSH, fT4 and fT3 are mostly narrower than intervals given by manufacturer. Median value, lower and upper limit for TSH, fT4 and fT3 were 1.98 (0.59–4.23) mIU/L, 14.5 (11.3–18.8) pmol/L and 4.82 (3.79–6.05) pmol/L, respectively. Most likely, an inclusion of a high number of healthy individuals without thyroid disease was a reason for such results.

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Reference intervals for thyroid‐stimulating hormone and thyroid hormones using the access TSH 3rd IS method in China

Cited by 7 publications

References 17 publications

The reference intervals for thyroid hormones: A four year investigation in Chinese population

The reference intervals for thyroid hormones: A four year investigation in Chinese population

Establishment of Reference Intervals for Thyroid-Associated Hormones Using refineR Algorithm in Chinese Population at High-Altitude Areas

First Estimation of Reference Intervals for Thyroid-Stimulating Hormone and Thyroid Hormones in Slovenian Population

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