Reference ranges (“normal values”) for cardiovascular magnetic resonance (CMR) in adults and children: 2020 update

Kawel‐Boehm, Nadine; Hetzel, Scott; Ambale-Venkatesh, Bharath; Captur, Gabriella; François, Christopher J.; Jerosch‐Herold, Michael; Salerno, Michael; Teague, Shawn D.; Valsangiacomo-Buechel, Emanuela; Geest, Rob J. van der; Bluemke, David A.

doi:10.1186/s12968-020-00683-3

Cited by 353 publications

(286 citation statements)

References 214 publications

(484 reference statements)

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“…However, since 2D-CMR-FT was possible in all SLV patients compared to 2D-STE and that it has become more easily available for routine CMR analyses, we believe that 2D-CMR-FT is a good alternative to 2D-STE. Furthermore, CMR reference values for LV strain values in children and adults exist and can be used for comparison [ 30 , 31 ].…”

Section: Discussionmentioning

confidence: 99%

Myocardial deformation in patients with a single left ventricle using 2D cardiovascular magnetic resonance feature tracking: a case–control study

Strodka

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Schuwerk

et al. 2021

Int J Cardiovasc Imaging

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Ventricular dysfunction is a well-known complication in single ventricle patients in Fontan circulation. As studies exclusively examining patients with a single left ventricle (SLV) are sparse, we assessed left ventricular (LV) function in SLV patients by using 2D-cardiovascular magnetic resonance (CMR) feature tracking (2D-CMR-FT) and 2D-speckle tracking echocardiography (2D-STE). 54 SLV patients (11.4, 3.1–38.1 years) and 35 age-matched controls (12.3, 6.3–25.8 years) were included. LV global longitudinal, circumferential and radial strain (GLS, GCS, GRS) and strain rate (GLSR, GCSR, GRSR) were measured using 2D-CMR-FT. LV volumes, ejection fraction (LVEF) and mass were determined from short axis images. 2D-STE was applied in patients to measure peak systolic GLS and GLSR. In a subgroup analysis, we compared double inlet left ventricle (DILV) with tricuspid atresia (TA) patients. The population consisted of 19 DILV patients, 24 TA patients and 11 patients with diverse diagnoses. 52 patients were in NYHA class I and 2 patients were in class II. Most SLV patients had a normal systolic function but median LVEF in patients was lower compared to controls (55.6% vs. 61.2%, p = 0.0001). 2D-CMR-FT demonstrated reduced GLS, GCS and GCSR values in patients compared to controls. LVEF correlated with GS values in patients (p < 0.05). There was no significant difference between GLS values from 2D-CMR-FT and 2D-STE in the patient group. LVEF, LV volumes, GS and GSR (from 2D-CMR-FT) were not significantly different between DILV and TA patients. Although most SLV patients had a preserved EF derived by CMR, our results suggest that, LV deformation and function may behave differently in SLV patients compared to healthy subjects.

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Section: Discussionmentioning

confidence: 99%

Myocardial deformation in patients with a single left ventricle using 2D cardiovascular magnetic resonance feature tracking: a case–control study

Strodka

Logoteta

Schuwerk

et al. 2021

Int J Cardiovasc Imaging

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“…By now, many studies have shown excellent feasibility and reproducibility of CMR-FT analyses tools [20][21][22] defined normal value ranges [23,24], investigated inter-vendor agreement of different available software vendors [25][26][27] and examined it in a wide range of cardiac diseases demonstrating their applicability and clinical utility (Fig. 4).…”

Section: Techniques Basic Principles and Measurement Capabilitiesmentioning

confidence: 99%

Quantification of Myocardial Deformation Applying CMR-Feature-Tracking—All About the Left Ventricle?

Lange

Schuster

2021

Curr Heart Fail Rep

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Purpose of Review Cardiac magnetic resonance-feature-tracking (CMR-FT)-based deformation analyses are key tools of cardiovascular imaging and applications in heart failure (HF) diagnostics are expanding. In this review, we outline the current range of application with diagnostic and prognostic implications and provide perspectives on future trends of this technique. Recent Findings By applying CMR-FT in different cardiovascular diseases, increasing evidence proves CMR-FT-derived parameters as powerful diagnostic and prognostic imaging biomarkers within the HF continuum partly outperforming traditional clinical values like left ventricular ejection fraction. Importantly, HF diagnostics and deformation analyses by CMR-FT are feasible far beyond sole left ventricular performance evaluation underlining the holistic nature and accuracy of this imaging approach. Summary As an established and continuously evolving technique with strong prognostic implications, CMR-FT deformation analyses enable comprehensive cardiac performance quantification of all cardiac chambers.

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“…Quantitative cardiovascular magnetic resonance (CMR) imaging can provide a wealth of information to distinguish health from disease [ 1 ]. Four-dimensional flow (4D flow) CMR allows for a comprehensive assessment of the blood flow kinetic energy (KE) of the left ventricle (LV) [ 2 ].…”

Section: Objectivementioning

confidence: 99%

Reproducibility of left ventricular blood flow kinetic energy measured by four-dimensional flow CMR

et al. 2021

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Objectives Four-dimensional flow CMR allows for a comprehensive assessment of the blood flow kinetic energy of the ventricles of the heart. In comparison to standard two-dimensional image acquisition, 4D flow CMR is felt to offer superior reproducibility, which is important when repeated examinations may be required. The objective was to evaluate the inter-observer and intra-observer reproducibility of blood flow kinetic energy assessment using 4D flow of the left ventricle in 20 healthy volunteers across two centres in the United Kingdom and the Netherlands. Data description This dataset contains 4D flow CMR blood flow kinetic energy data for 20 healthy volunteers with no known cardiovascular disease. Presented is kinetic energy data for the entire cardiac cycle (global), the systolic and diastolic components, in addition to blood flow kinetic energy for both early and late diastolic filling. This data is available for reuse and would be valuable in supporting other research, such as allowing for larger sample sizes with more statistical power for further analysis of these variables.

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Reference ranges (“normal values”) for cardiovascular magnetic resonance (CMR) in adults and children: 2020 update

Cited by 353 publications

References 214 publications

Myocardial deformation in patients with a single left ventricle using 2D cardiovascular magnetic resonance feature tracking: a case–control study

Myocardial deformation in patients with a single left ventricle using 2D cardiovascular magnetic resonance feature tracking: a case–control study

Quantification of Myocardial Deformation Applying CMR-Feature-Tracking—All About the Left Ventricle?

Reproducibility of left ventricular blood flow kinetic energy measured by four-dimensional flow CMR

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