Reference Values for Arterial Blood Gases in the Elderly

Hardie, Jon A.; Vollmer, William M.; Buist, A. Sonia; Ellingsen, Ivar; Mørkve, Odd

doi:10.1378/chest.125.6.2053

Cited by 81 publications

(57 citation statements)

References 19 publications

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“…Subjects .75 yrs of age had a similar SP,O 2 to subjects aged 65-70 yrs. In previous studies, Pa,O 2 also did not decrease with age in subjects .70 yrs [23][24][25]. This is likely to represent a cohort effect, with survivors, and it does not mean that a person of 65 yrs of age should expect a constant SP,O 2 in subsequent years.…”

Section: Discussionmentioning

confidence: 56%

Prevalence of oxygen desaturation and use of oxygen at home in adults at sea level and at moderate altitude

Pérez‐Padilla

Torre-Bouscoulet²,

Muiño³

et al. 2006

Eur Respir J

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, on behalf of the Proyecto Latinoamericano de Investigacion en Obstruccion Pulmonar (PLATINO) group ABSTRACT: The aim of this study was to determine the prevalence of oxygen desaturation in adults aged o40 yrs as altitude above sea level increases.A population-based, cross-sectional study with a multistage cluster sampling of 1,063 subjects from metropolitan Mexico City (Mexico; 2,240 m above sea level), 1,357 from Caracas (Venezuela; 950 m) and 943 from Montevideo (Uruguay; 35 m). The mean of six measurements of arterial oxygen saturation (SP,O 2 ) was estimated using a pulse oximeter.Mean SP,O 2 decreased with altitude. No subject from Montevideo had a mean SP,O 2 f88%. Prevalence of subjects with SP,O 2 f88%, a common criterion used for oxygen prescription, was 1.0% in Caracas and 6.0% in Mexico City. Additional predicting factors for hypoxaemia in multiple regression models were age, body mass index and a low forced expiratory volume in one second as a percentage of the predicted value. In Mexico City and Caracas, ,10% of the hypoxaemic subjects reported use of domiciliary oxygen, whereas at least half of the subjects reporting use of oxygen at home had a resting SP,O 2 .88%.In conclusion, the prevalence of hypoxaemia was closely related to altitude. Priorities for oxygen prescription must be defined in moderate altitudes because it is unfeasible to provide it to all subjects fulfilling the criteria commonly used.

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Section: Discussionmentioning

confidence: 56%

Prevalence of oxygen desaturation and use of oxygen at home in adults at sea level and at moderate altitude

Pérez‐Padilla

Torre-Bouscoulet²,

Muiño³

et al. 2006

Eur Respir J

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“…Studies in geriatric dogs have not shown a significant difference in PaO 2 or PaCo 2 results compared to younger dogs 16, 17. There is a well‐characterized age‐related decrease in the PaO 2 of humans that reaches a plateau as humans reach their early‐mid 70s 18, 19…”

Section: Discussionmentioning

confidence: 98%

Age Effects on Blood Gas, Spirometry, Airway Reactivity, and Bronchoalveolar Lavage Fluid Cytology in Clinically Healthy Horses

Pacheco

Paradis

Hoffman

et al. 2014

Veterinary Internal Medicne

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BackgroundDespite the increasing number of geriatric horses attended by veterinarians, there is a lack of understanding of aging‐related changes on the respiratory system of horses.ObjectiveTo identify aging‐related changes on the respiratory function and bronchoalveolar lavage fluid (BALF) cytology of horses.AnimalsFifteen healthy young adult (2–11 years) and 16 healthy aged (≥20 years) horses.MethodsThe respiratory system was examined by measurement of arterial blood gases (ABG), use of respiratory inductive plethysmography (RIP) for assessment of breathing pattern and ventilatory parameters, histamine bronchoprovocation, and BALF cytology.ResultsNo significant differences were detected with regard to values obtained by ABG or bronchoprovocation of young adult and aged healthy horses. In aged horses, there were significant differences in mean ± SD of the following parameters when compared to young horses: prolonged expiratory time (Te) measured by RIP (3.9 ± 1.5 s versus 3.0 ± 0.6 s), decreased percentage of alveolar macrophages (40.6 ± 11.3% versus 53.5 ± 9.6%), and increased percentage of lymphocytes (53.4 ± 9.5% versus 43.9 ± 11.0%). No correlations between airway reactivity and ventilatory parameters, ABG, or BALF cytology were found in this asymptomatic population.ConclusionsThese results suggest that aging does not cause changes in the results obtained by ABG, most RIP‐derived variables, and bronchoprovocation in the horse. A decreased percentage of macrophage and an increased percentage of lymphocytes in the BALF cytology may be expected in the asymptomatic geriatric horse and may be a result of aging.

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“…However, there are many studies in the literature that consider the methodology, techniques and equipment required to measure arterial blood gases [85,90,91]. The frequency distribution of blood gas values has been established for the general population; reference equations based on the distribution of Pa,O 2 in normal populations have been made available by studies on different ethnic groups and age ranges [92,93]. In COPD patients, Pa,O 2 has been used to define respiratory failure (Pa,O 2 ,7.98 kPa (,60 mmHg)) and it was included for adopting treatment strategies in COPD based on severity classification and disease progression [11].…”

Section: Gas Exchangementioning

confidence: 99%

Outcomes for COPD pharmacological trials: from lung function to biomarkers

Cazzola¹,

MacNee²,

Martínez³

et al. 2008

Eur Respir J

752

566

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The American Thoracic Society/European Respiratory Society jointly created a Task Force on “Outcomes for COPD pharmacological trials: from lung function to biomarkers” to inform the chronic obstructive pulmonary disease research community about the possible use and limitations of current outcomes and markers when evaluating the impact of a pharmacological therapy. Based on their review of the published literature, the following document has been prepared with individual sections that address specific outcomes and markers, and a final section that summarises their recommendations.

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Reference Values for Arterial Blood Gases in the Elderly

Cited by 81 publications

References 19 publications

Prevalence of oxygen desaturation and use of oxygen at home in adults at sea level and at moderate altitude

Prevalence of oxygen desaturation and use of oxygen at home in adults at sea level and at moderate altitude

Age Effects on Blood Gas, Spirometry, Airway Reactivity, and Bronchoalveolar Lavage Fluid Cytology in Clinically Healthy Horses

Outcomes for COPD pharmacological trials: from lung function to biomarkers

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