Reference values for serum ferritin in Chinese Han ethnic males: Results from a Chinese male population survey

Li, Shan; Lin, Lih‐Chang; Mo, Zengnan; Qin, Xue; Lv, Hui; Gao, Yong; Yang, Xiaobo; Huang, Shan; Chen, Zhiping

doi:10.1016/j.clinbiochem.2011.08.1137

Cited by 10 publications

(7 citation statements)

References 26 publications

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“…However, compared with that study, 40 our study had slightly but significantly lower RIs for SF in Chinese adult males. This may be related to the different assay methods used, as reported in previous studies.…”

Section: Number Of Outlierscontrasting

confidence: 92%

“…In fact, in multi‐ethnic population studies in the USA, Adams et al had proved that elevated SF levels are more frequent in Afro‐Caribbean and Asian subjects than in whites or Hispanics. In a previous Chinese study on Cobas® 6000 system E601 (Roche) analyzer, Li et al also found that Chinese adult males had higher RIs for SF. However, compared with that study, our study had slightly but significantly lower RIs for SF in Chinese adult males.…”

Section: Discussionmentioning

confidence: 94%

“…In a previous Chinese study on Cobas® 6000 system E601 (Roche) analyzer, Li et al also found that Chinese adult males had higher RIs for SF. However, compared with that study, our study had slightly but significantly lower RIs for SF in Chinese adult males. This may be related to the different assay methods used, as reported in previous studies .…”

Section: Discussionmentioning

confidence: 94%

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Reference intervals established using indirect method for serum ferritin assayed on Abbott Architect i2000_SR analyzer in Chinese adults

Wang

Guo²,

et al. 2019

Clinical Laboratory Analysis

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Background Serum ferritin (SF) test has been widely used in clinical practice. However, its reference intervals (RIs) vary depending on the analytical method and ethnic origin. This study was to establish the RIs using indirect method for SF in Chinese adults. Methods SF was assayed on Abbott i2000SR analyzer. The SF test results of all health examinees (8913 males aged 18‐93 years and 5397 females aged 18‐90 years) between December 2010 and April 2019 were obtained from our laboratory information system. After Box‐Cox transformation of raw data and exclusion of outliers, parametric and non‐parametric approaches were used to calculate 95% RIs. The correlation between SF levels and ages, and the differences in SF levels between subgroups were also analyzed. Results SF levels in females were significantly different from those in males (Z = 88.96, Z* = 23.17; Z > Z*) and showed a weak positive correlation with age (r = .466, P < .0001). The RIs based on parametric approach in males were 66.12‐561.58 µg/L, whereas in all females were 3.59‐269.59 µg/L, females aged <50 years 3.26‐148.02 µg/L and those aged ≥50 years 17.28‐303.27 µg/L. The RIs based on non‐parametric approach in males were 65.00‐571.37 µg/L whereas in all females were 4.00‐254.00 µg/L, females aged <50 years 4.00‐152.00 µg/L and those aged ≥50 years 16.00‐304.05 µg/L. Conclusions Our indirect RIs for SF were markedly different from the manufacturer's recommended RIs and might be more suitable for Chinese adults, which would be helpful in interpreting laboratory data and clinical decision‐making.

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Section: Number Of Outlierscontrasting

confidence: 92%

Section: Discussionmentioning

confidence: 94%

Section: Discussionmentioning

confidence: 94%

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Reference intervals established using indirect method for serum ferritin assayed on Abbott Architect i2000_SR analyzer in Chinese adults

Wang

Guo²,

et al. 2019

Clinical Laboratory Analysis

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“…Our results showed SF levels in smokers with primary lung cancer were not significantly higher than non-smokers with primary lung cancer ( p=0.037 ). There is recent evidence that the non-smoking and smoking healthy men exhibited no difference in SF levels [ 28 ]. Higher SF levels are associated with a higher Body Mass Index [ 21 , 28 ].…”

Section: Discussionmentioning

confidence: 99%

Serum ferritin and primary lung cancer

Chen

Zhu

et al. 2017

Oncotarget

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Existing research yields conflicting results regarding the relation between iron deficiency and high serum ferritin (SF) levels in primary lung cancer patients. We investigated the concentrations of SF, hemoglobin (Hb) and transferrin (TRF) in 569 male primary lung cancer patients and 252 female primary lung cancer patients. We grouped the subjects according to gender, smoking status, menopausal status, pathological type, stage, and TNM stage. The levels of SF and TRF were correlated with T stage in male patients (p<0.01). The levels of SF and TRF were correlated with menopausal status in female patients (p<0.01). Hb was correlated with smoking status, pathological type, stage, and TNM stages in male patients(p<0.01), but in female patients, Hb was not correlated with these grouping factors(p>0.05). The levels of SF may be regulated by different mechanisms and may be of different physiological significance in different populations.

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“…We excluded the participants with the self-reported information of neoplastic condition, diagnosis of chronic disease, infection with acute infectious diseases, use of any drug with a known effect on the endocrine system or who was considered as prescribed in the past two weeks and people whose data was incomplete about smoking and alcohol consumption were also excluded. Thus, 1999 men was finally recruited and then 10.0 ml venous blood samples was collected from everyone [24].…”

Section: Methodsmentioning

confidence: 99%

The Association between the Levels of Serum Ferritin and Sex Hormones in a Large Scale of Chinese Male Population

Liu

Zhang

et al. 2013

PLoS ONE

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BackgroundThe ferritin is an important participant of iron-storage but its regulation and related factors were not well defined. The present objective was to explore the potential association between serum ferritin levels and sex hormones.Methods1999 Chinese men in the Fangchenggang Area Male Health and Examination Survey (FAMHES) were recruited in this cross-sectional study. Levels of serum ferritin, total testosterone (free testosterone was calculated from the total one), estradiol and sex hormone-binding protein were detected in venous blood samples. The effects of age, BMI, smoking as well as alcohol consumption were analyzed on ferritin levels, respectively, and then the Pearson’s correlation analysis was used to evaluate the association between ferritin levels and sex hormones adjusting for the above factors.ResultsThe age, BMI and alcohol consumption significantly affected serum ferritin levels, but there was no significant difference between smokers and nonsmokers. Ferritin levels were significantly and negatively associated with total testosterone (R = −0.205, P< 0.001), sex hormone-binding protein (R = −0.161, P<0.001) and free testosterone (R = −0.097, P<0.001). After age and alcohol consumption were adjusted, the above associations were still significant (R = −0.200, −0.181 and −0.083, respectively, all P<0.001). However, there was only borderline negative association between ferritin levels and estradiol (adjusted R = −0.039, P = 0.083).ConclusionThe large scale of epidemic results showed the significantly negative associations between serum ferritin levels and sex hormones, which may provide more clues to explore the potential regulation and biological mechanism of ferritin.

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Reference values for serum ferritin in Chinese Han ethnic males: Results from a Chinese male population survey

Cited by 10 publications

References 26 publications

Reference intervals established using indirect method for serum ferritin assayed on Abbott Architect i2000_SR analyzer in Chinese adults

Reference intervals established using indirect method for serum ferritin assayed on Abbott Architect i2000_SR analyzer in Chinese adults

Serum ferritin and primary lung cancer

The Association between the Levels of Serum Ferritin and Sex Hormones in a Large Scale of Chinese Male Population

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Reference values for serum ferritin in Chinese Han ethnic males: Results from a Chinese male population survey

Cited by 10 publications

References 26 publications

Reference intervals established using indirect method for serum ferritin assayed on Abbott Architect i2000SR analyzer in Chinese adults

Reference intervals established using indirect method for serum ferritin assayed on Abbott Architect i2000SR analyzer in Chinese adults

Serum ferritin and primary lung cancer

The Association between the Levels of Serum Ferritin and Sex Hormones in a Large Scale of Chinese Male Population

Contact Info

Product

Resources

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Reference intervals established using indirect method for serum ferritin assayed on Abbott Architect i2000_SR analyzer in Chinese adults

Reference intervals established using indirect method for serum ferritin assayed on Abbott Architect i2000_SR analyzer in Chinese adults