Refined association of melanoma differentiation‐associated gene 5 variants with spontaneous hepatitis C virus clearance in Egypt

Abstract

commercial assays (14 of 343; 4.1%) were instead precisely resolved by HCV sequencing. As a whole, 28 of 343 (8.2%) patients achieved the correct genotyping assignment by sequencing. The overall percentage of genotype/subtype resolved by direct sequencing in the current study is similar to what has been found in other recent publications. (3,5) Our results emphasize the importance of dedicating time and effort for a proper genotype/subtype assignment before starting therapy. HCV sequencing allows precise subtype/genotype assignment, along with evaluation of natural resistance, thus reducing the risk of failure, especially in difficult-to-treat patients. The relatively low cost of sequencing (compared to therapy) should encourage studies aimed at better defining the advantage of its use at therapy baseline.

An IFIH1 gene polymorphism associated with risk for autoimmunity regulates canonical antiviral defence pathways in Coxsackievirus infected human pancreatic islets

“…In parallel, the islet cohort was genotyped for the rs3747517 SNP (Supplementary Table S1). The results from this genotyping were in line with the previously published strong linkage disequilibrium with rs19907609163031.…”

“…Taken together, this and our study suggest that there may be subtle, yet important biological differences between the genotypes in terms of controlling enterovirus replication. This is in line with other investigations indicating a weak but possible link between the rs1990760 polymorphism in the clearance of both enterovirus 714445 and hepatitis C virus1630.…”

The A946T variant of the RNA sensor IFIH1 mediates an interferon program that limits viral infection but increases the risk for autoimmunity

“…Further, haplotypes at IFIH1 encoding His at position 843 and Thr at position 946 were reported to correlate with the resolution of hepatitis C virus (HCV) 28 . Notably, we found IFIH1 H843/T946 was very rare in our data, consistent other recent reports 48 , 49 . Thus, at the population level, the impact of the common risk haplotype (IFIH1 T946/R843 ) upon response to viral challenge and autoimmune disease risk is likely to be important; whereas the impact of the rare IFIH1 H843/T946 haplotype would be negligible.…”