The Chelopech deposit is one of the largest European gold deposits and is located 60 km east of Sofia, within the northern part of the Panagyurishte mineral district. It lies within the Banat-Srednegorie metallogenic belt, which extends from Romania through Serbia to Bulgaria. The magmatic rocks define a typical calc-alkaline suite. The magmatic rocks surrounding the Chelopech deposit have been affected by propylitic, quartz-sericite, and advanced argillic alteration, but the igneous textures have been preserved. Alteration processes have resulted in leaching of Na 2 O, CaO, P 2 O 5 , and Sr and enrichment in K 2 O and Rb. Trace element variation diagrams are typical of subduction-related volcanism, with negative anomalies in high field strength elements (HFSE) and light element, lithophile elements. HFSE and rare earth elements were relatively immobile during the hydrothermal alteration related to ore formation. Based on immobile element classification diagrams, the magmatic rocks are andesitic to dacitic in compositions. Single zircon grains, from three different magmatic rocks spanning the time of the Chelopech magmatism, were dated by high-precision U-Pb geochronology. Zircons of an altered andesitic body, which has been thrust over the deposit, yield a concordant 206 are related to two distinct upper crustal magmatic reservoirs, and they cannot be considered as a genetically paired porphyry-Cu and high-sulfidation epithermal related to a single magmatic-hydrothermal system centered on the same intrusion.