Reflection of caustics and focused sonic booms

Synthesis, Labeling and Biological Evolution of New Thiopyrano[2,3-b]Pyridine Derivatives as Potential Anticancer Agents

“…The mice were injected with 0.2 mL (70 KBq) 125 I-TP 5 in the tail vein and then divided to 4 groups, 6 mice each. The mice were kept in metabolic cages for the recommended times (15,30,60 or 180 min) after injection of labeled drug. Mice were sacrificed by cervical dislocation at various time intervals.…”

“…[10][11][12][13] In recent years, the synthesis and antifungal activities of 3-substituted methylene-4-oxothiopyrano [2,3-b]pyridines were published. 14,15 A number of the spiropyrazolo-3,3'-thiopyrano [2,3-b] pyridines and new tetra-and penta-heterocycles, which could be obtained by treating 3-(N,N-dimethylamino) methylene derivatives with nitrilimines and aminoazoles, respectively, showed high antifungal and anti-bacterial activities. 15 Motivated by the above literature observations and our own previous reports, [16][17][18] herein we describe the use of the 4,6-dimethylnicotinonitrile-2-thiol (1) for the synthesis of thiopyranopyridine heterocyclic ring systems (Schemes 1-3) to investigate their antitumor activities.…”

“…14,15 A number of the spiropyrazolo-3,3'-thiopyrano [2,3-b] pyridines and new tetra-and penta-heterocycles, which could be obtained by treating 3-(N,N-dimethylamino) methylene derivatives with nitrilimines and aminoazoles, respectively, showed high antifungal and anti-bacterial activities. 15 Motivated by the above literature observations and our own previous reports, [16][17][18] herein we describe the use of the 4,6-dimethylnicotinonitrile-2-thiol (1) for the synthesis of thiopyranopyridine heterocyclic ring systems (Schemes 1-3) to investigate their antitumor activities. In addition, we were able to perform the iodine labeling of the new compound 5 using NBS as an oxidizing agent and examined the factors affecting the labeling yield.…”

Characterization of topographic effects on sonic boom reflection by resolution of the Euler equations

“…It is thus common in prediction models to account for ground reflection by multiplying the sonic boom incident to the ground by a constant factor, usually equal to 1.9 [for instance, in recent papers Ueno et al (2017) and Phillips and West (2019)]. However, for specific configurations such as focused booms and booms near the carpet cut-off, studies (Coulouvrat, 2002;Rend on and Coulouvrat, 2005) have shown that ground absorption significantly affects the sonic boom signature with a reduction of the peak overpressure and an increase in rise time. Similar effects have been observed for sea roughness (Boulanger and Attenborough, 2005).…”

Cuspidal caustic and focusing of acoustical waves generated by a parametric array onto a concave reflecting surface

“…Here the focusing effects are explained by gradient properties within the propagating media creating channelling multi-layered structures, or they are due to subtle inhomogeneity effects for long range propagation, in some cases linked to mirage behaviour in moving media, and so forth. Caustics and focusing effects have also been studied when nonlinear acoustic behaviour are considered, as well as in water [11], and in air propagation such as for the propagation of shock waves during sonic boom [12][13][14]. Turbulent flows are also at the origin of focusing effects and at the onset of caustics, as it was clearly established during the last 20 years [15][16][17][18].…”