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in Wiley Online Library (wileyonlinelibrary.com).Syntheses of some new heterocyclic compounds containing pyridone, thioxopyridine, halogenated-pyridinecarbonitriles, pyrazolopyridine, and pyridine derivatives were achieved. Besides, a modified synthetic method for the synthesis of 2-chloro-4,6-dimethyl-nicotinonitrile (3) through the reaction of acetylacetone and malononitrile as starting materials was implemented. The reaction of 2-chloronicotinonitrile 3 with substituted amines to 2-aminonicotinonitrile were also investigated. Fused or binary pyridines were tested for cytotoxicity against well-known established model Ehrlich ascites cells in vitro. Compound 13 exhibited a high antitumor activity compared with 5-fluorouracil.

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