Utilization of nicotinonitrile-2-thiol in the synthesis of new thiepino[2,3-b]pyridine derivative as an in vitro novel antitumor potent

Synthesis, Labeling and Biological Evolution of New Thiopyrano[2,3-b]Pyridine Derivatives as Potential Anticancer Agents

“…14,15 A number of the spiropyrazolo-3,3'-thiopyrano [2,3-b] pyridines and new tetra-and penta-heterocycles, which could be obtained by treating 3-(N,N-dimethylamino) methylene derivatives with nitrilimines and aminoazoles, respectively, showed high antifungal and anti-bacterial activities. 15 Motivated by the above literature observations and our own previous reports, [16][17][18] herein we describe the use of the 4,6-dimethylnicotinonitrile-2-thiol (1) for the synthesis of thiopyranopyridine heterocyclic ring systems (Schemes 1-3) to investigate their antitumor activities. In addition, we were able to perform the iodine labeling of the new compound 5 using NBS as an oxidizing agent and examined the factors affecting the labeling yield.…”

Synthesis of novel bioactive pyrido[2,3-d]pyrimidine derivatives with potent cytotoxicity through apoptosis as PIM-1 kinase inhibitors

“…7,8 Because of their many biological uses, pyridine nuclei are signicant nitrogen-containing heterocyclic systems. Important biological processes include anticancer, 9 anti-Alzheimer's disease, 10 antibacterial, 11 antitubercular, 12 antifungal, 13 anti-inammatory 14 activities, and the management of several cardiovascular disorders, including hypertension and angina. 15 In addition, pyridine derivatives were shown to halt the proliferation of human MCF-7 and HepG-2 cancer cells by increasing JNK levels and causing G2/M phase arrest via a p53-p21-driven pathway.…”

“…It was reported that incorporating pyridine derivatives exhibited potent anticancer activity against cancer cell lines such as HepG2 and MCF-7. 10 2 Material and methods…”

Utility of activated nitriles in the synthesis of some new pyridine and fused pyridine derivatives with anticancer activity.

“…Pyridine nuclei are considered as important nitrogen containing heterocyclic systems owing to their several biological activities 1,2 . Among the important biological activities are anticancer 3,4 , treatment of Alzheimer's disease 5,6 , antibacterial 7 , antitubercular 8 , antifungal 9 , anti-inflammatory 10 activities and the treatment of many cardiovascular diseases such as angina and hypertension 11 .…”

“…A class of thieno [2,3-b]pyridine compounds have a potent anticancer activity against a variety of tumor cell lines 19,20 such as breast cancer cell line MDA-MB-231 21 and MDA-MB-435 melanoma cell line 22 . While, [1,6]naphthyridines derivatives were found to have anticancer activity against melanoma cell line (MDA-MB-435) 22 . Therefore, our aim was to synthesize and evaluate the anticancer activity of various fused and substituted pyridine analogues.…”