The public service is the main tool governments use to implement various national development policies and deliver services. An efficient public service requires a good interface between the political and administrative leadership to ensure that polices are formulated and implemented properly. The relationship between politics and administration has been a controversial subject in public administration. This paper examines the role and impact of politics on public service human resource management systems in Malawi. How people are recruited, selected, appointed, oriented, trained, promoted rewarded or disciplined affect their commitment, motivation and productivity. While at the formal level, ministers do not have prominent role in recruitment, promotion, demotion or transfer of public servants, in practice, political interference in appointments, promotion, transfer and demotion of public servants is widely perceived in the Malawi public service. The paper concludes with optimism that if the Vice President-led system-wide public sector reform recommendations are implemented properly, some of the challenges regarding political interference in public sector human resource management will be reduced.