Reflections on the modified simplex—II1

Betteridge, D.; Wade, Adrian P.; Howard, A.G.

doi:10.1016/0039-9140(85)80175-2

Cited by 71 publications

(20 citation statements)

References 23 publications

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“…[8][9][10][11] A number of studies on the modification and improvement of the original algorithm have been published over the last 20 years. [12][13][14][15][16] In this study, we therefore decided to utilize the simplex method for optimizing the mobile phase content in an analysis of ionic liquid cations. In this paper, we present our data on the optimization of HPLC separation of ionic liquid cations on a polar reverse stationary phase using a variable-size simplex algorithm.…”

Section: Introductionmentioning

confidence: 99%

Simplex-optimized Chromatographic Resolution of Selected Ionic Liquid Cations Utilizing a Polar Reversed-Phase System

et al. 2008

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This study reports on optimization of the RP-HPLC separation of imidazolium and pyridinium ionic liquid cations using a variable-size simplex algorithm. Under the optimized conditions, all critical pairs of ionic liquids were successfully separated in a single chromatographic run. The mobile phase at the point corresponding to the optimum consisted of 10% MeOH and 90% 15 mM KH2PO4/H3PO4 with pH 3.43. The coefficients of asymmetry for all of the compounds analyzed at the simplex algorithm optimum ranged from 0.83 to 2.91.

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Section: Introductionmentioning

confidence: 99%

Simplex-optimized Chromatographic Resolution of Selected Ionic Liquid Cations Utilizing a Polar Reversed-Phase System

et al. 2008

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“…Subsequently, the estimated optimum might be a local optimum. By consequence, a modified Simplex [55] and super-modified Simplex [56,57] have been recommended. These modifications are base on reflection, contraction and expansion of the vertices of a geometric figure with one vertex more than the number of variables to be optimised.…”

Section: Simplex Methodsmentioning

confidence: 99%

An overview of qualimetric strategies for optimisation and calibration in pharmaceutical analysis using flow injection techniques

Bosque-Sendra

Gámiz‐Gracia

Garcı́a-Campaña

2003

Analytical and Bioanalytical Chemistry

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Flow Injection analysis represents an attractive tool because of its great advantages, such as versatility, speed, high sampling rate and wide applicability in the field of pharmaceutical analysis. However, due to the inherent characteristics of the technique, the choice of the best set of operational and chemical conditions is complicated and the conventional univariate optimisation method present some limitations, mainly due to fact that the interdependence of variables is not considered. In relation to the calibration process, because of the transient character of the signals obtained using FIA manifolds coupled with different detection techniques, different strategies can be used in calibration to solve some problems related to the nature of the signal thereby improving the performance characteristics of the method. This paper offers an overview of different methodologies used in optimisation based on the use of statistically designed experiments and some strategies developed for calibration applied to the analysis of pharmaceuticals.

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“…Software was written in Microsoft Q U~C~B A S I C~ version 4.0, as was the code used for nonlinear curve fitting and other data processing tasks. The optimization algorithm used was the composite modified simplex method (14,19,20). Response surface plots were generated using a commercial scientific graphics program (SURFERR v. 3.0, Golden Software, Golden, CO).…”

Section: Apparatusmentioning

confidence: 99%

Spectrophotometric determination of peroxydisulphate with o-dianisidine by flow injection

Shiundu¹,

Wade²,

Jonnalagadda³

1990

Can. J. Chem.

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Precise and accurate knowledge of peroxydisulfate ion concentration is critical in industrial polymer production, where it is extensively used as an activator. Its ability to oxidize in either acidic, neutral, or alkali media also makes it widely applicable in many other areas of chemistry.In this paper we present an optimized spectrophotometric flow injection method for determination of peroxydisulfate. The analyte oxidizes o-dianisidine to form a stable product which has a convenient absorbance maximum at 450 nm. This provides a simple and sensitive alternative to present methods which are more costly, tedious, or complex.

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Reflections on the modified simplex—II1

Cited by 71 publications

References 23 publications

Simplex-optimized Chromatographic Resolution of Selected Ionic Liquid Cations Utilizing a Polar Reversed-Phase System

Simplex-optimized Chromatographic Resolution of Selected Ionic Liquid Cations Utilizing a Polar Reversed-Phase System

An overview of qualimetric strategies for optimisation and calibration in pharmaceutical analysis using flow injection techniques

Spectrophotometric determination of peroxydisulphate with o-dianisidine by flow injection

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