Reflections on the Role of Malat1 in Gynecological Cancer

Liao, Huiyan; Chen, Qi; Xiao, Jing

doi:10.2147/cmar.s286804

Cited by 10 publications

(4 citation statements)

References 96 publications

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“…These cancers mainly include breast, ovarian, uterine, vaginal, cervical, and vulvar [46]. LncRNA-MALAT1 is a potential biomarker for disease diagnosis and prognosis and a candidate for drug targeting in treating gynecological tumors [47].…”

Section: The Role Of Lncrna-malat1 In Gynecological Cancersmentioning

confidence: 99%

LncRNA-MALAT1: A Key Participant in the Occurrence and Development of Cancer

Hao

et al. 2023

Molecules

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LncRNAs are a group of non-coding RNA transcripts with lengths of over 200 nucleotides and can interact with DNA, RNA, and proteins to regulate gene expression of malignant tumors in human tissues. LncRNAs participate in vital processes, such as chromosomal nuclear transport in the cancerous site of human tissue, activation, and the regulation of proto-oncogenes, the differentiation of immune cells, and the regulation of the cellular immune system. The lncRNA metastasis-associated lung cancer transcript 1 (MALAT1) is reportedly involved in the occurrence and development of many cancers and serves as a biomarker and therapeutic target. These findings highlight its promising role in cancer treatment. In this article, we comprehensively summarized the structure and functions of lncRNA, notably the discoveries of lncRNA-MALAT1 in different cancers, the action mechanisms, and the ongoing research on new drug development. We believe our review would serve as a basis for further research on the pathological mechanism of lncRNA-MALAT1 in cancer and provide evidence and novel insights into its application in clinical diagnoses and treatments.

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Section: The Role Of Lncrna-malat1 In Gynecological Cancersmentioning

confidence: 99%

LncRNA-MALAT1: A Key Participant in the Occurrence and Development of Cancer

Hao

et al. 2023

Molecules

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“…As miRNA sponges, circular RNAs affect downstream genes by suppressing miRNA-associated repression, leading to alterations in the malignant phenotype of cervical cancer cells ( Najafi et al, 2022 ). MALAT1 expression in tissues and secretions (e.g., cervical vaginal lavage) is highly variable and has potential use as a biomarker of cervical cancer, which could be used for clinical diagnosis and treatment ( Liao et al, 2020 ). In patients with ovarian cancer, high levels of MALAT1 expression in localized lesions or in serum exosomes may indicate a poor prognosis ( Lin et al, 2018 ; Qiu et al, 2018 ).…”

Section: Discussionmentioning

confidence: 99%

Mechanistic studies of MALAT1 in respiratory diseases

Wang

Zhang

et al. 2022

Front. Mol. Biosci.

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Background: The incidence of respiratory diseases and the respiratory disease mortality rate have increased in recent years. Recent studies have shown that long non-coding RNA (lncRNA) MALAT1 is involved in various respiratory diseases. In vascular endothelial and cancer cells, MALAT1 expression triggers various changes such as proinflammatory cytokine expression, cancer cell proliferation and metastasis, and increased endothelial cell permeability.Methods: In this review, we performed a relative concentration index (RCI) analysis of the lncRNA database to assess differences in MALAT1 expression in different cell lines and at different locations in the same cell, and summarize the molecular mechanisms of MALAT1 in the pathophysiology of respiratory diseases and its potential therapeutic application in these conditions.Results: MALAT1 plays an important regulatory role in lncRNA with a wide range of effects in respiratory diseases. The available evidence shows that MALAT1 plays an important role in the regulation of multiple respiratory diseases.Conclusion: MALAT1 is an important regulatory biomarker for respiratory disease. Targeting the regulation MALAT1 could have important applications for the future treatment of respiratory diseases.

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“…plays an important role in promoting the occurrence, development, invasion and migration of tumors. [21,22] RBM10 is a nuclear protein existing in nucleosomes, and MALAT1 is also an intranuclear RNA, which means that they have the possibility of co-localization. We con rmed this hypothesis by RNA immunocoprecipitation experiment.…”

Section: Disscusionmentioning

confidence: 99%

RBM10, a new potential RBP function, recruits METTL3 to induce N6-methyladenosine-MALAT1-dependent modification on inhibiting the invasion and migration of NSCLC

Cao

Cong

et al. 2022

Preprint

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Background: Previous studies have shown that RBM10 is a potential tumor suppressor protein that can inhibit proliferation and promote apoptosis of NSCLC. RBM10 can bind and modify RNA at the post transcriptional level.Method and results: Transwell and cell wound healing assay showed that RBM10 significantly inhibited the invasion and migration of NSCLC. CLIP-seq showed that among all RBM10 binding RNAs, lncRNA MALAT1 with high m6A methylation in lung cancer had the highest binding peak among all non-coding RNAs. RNA Immunoprecipitation has verified the direct combination of RBM10 and MALAT1. The rescue experiment confirmed that RBM10 affected the phosphorylation of PI3K/AKT/mTOR passway protein, the invasion and migration ability by regulating MALAT1. MeRIP-qPCR confirmed that RBM10 could inhibit MALAT1 m6A methylation levels by recruiting METTL3.Conclusion: These results suggest that RBM10, as an RNA-binding protein, may inhibit m6A methylation of MALAT1 by recruiting METTL3, and affect phosphorylation of the downstream PI3K/AKT/mTOR pathway by binding and regulating MALAT1, ultimately affecting the invasion and migration of NSCLC.

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Reflections on the Role of Malat1 in Gynecological Cancer

Cited by 10 publications

References 96 publications

LncRNA-MALAT1: A Key Participant in the Occurrence and Development of Cancer

LncRNA-MALAT1: A Key Participant in the Occurrence and Development of Cancer

Mechanistic studies of MALAT1 in respiratory diseases

RBM10, a new potential RBP function, recruits METTL3 to induce N6-methyladenosine-MALAT1-dependent modification on inhibiting the invasion and migration of NSCLC

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