Reflectron time-of-flight mass spectrometry and laser excitation for the analysis of neutrals, ionized molecules and secondary fragments

Boesl, U.; Weinkauf, R.; Schlag, E. W.

doi:10.1016/0168-1176(92)80001-h

Cited by 162 publications

(90 citation statements)

References 70 publications

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“…In the MPI regime ( > 1) up to 10 10 W cm À2 , as the intensity becomes higher and the pulse duration becomes longer, the ionization process changes from soft ionization (where only parent ions appear) to hard fragmentation (small fragments are produced). 50,[61][62][63] The ladder switching from photon absorption by the neutral to that by the parent ion takes place. 61,62 The second ladder switching from the parent ion to fragment ions is typical for most polyatomic molecules.…”

Section: Multiphoton Ionization and Tunnel Ionizationmentioning

confidence: 99%

Theoretical Investigations of the Electronic and Nuclear Dynamics of Molecules in Intense Laser Fields: Quantum Mechanical Wave Packet Approaches

Kono

Satô

Kanno

et al. 2006

Bulletin of the Chemical Society of Japan

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We have developed a method for describing the reaction dynamics of a polyatomic molecule in intense laser fields. First, the dynamical behavior of H 2 þ and H 2 in near-infrared, intense laser fields (I > 10 13 W cm À2 and ! > 700 nm) was examined; accurate evaluation of the electronic and nuclear wave packet was achieved by the dual transformation method that we developed. Using ''field-following'' time-dependent adiabatic states defined as eigenfunctions of the ''instantaneous'' electronic Hamiltonian, we have clarified the dynamics of bound electrons, ionization processes, Coulomb explosion processes, and molecular vibrations of H 2 þ and H 2 . The analyses indicate that the multielectron dynamics and nuclear dynamics of polyatomic molecules in intense fields can be described by using the potential surfaces of time-dependent adiabatic states and the nonadiabatic coupling elements between those states. To obtain time-dependent adiabatic states of a molecule, one can diagonalize the electronic Hamiltonian including the interaction with the instantaneous laser electric field by ab initio molecular orbital (MO) methods. The time-dependent adiabatic potentials obtained are used to evaluate the multichannel nuclear dynamics until the next ionization process. We have applied the time-dependent adiabatic state approach to reveal the characteristic features of the dynamics of structural deformations of CO 2 and its cations in a near-infrared intense laser field. The experimentally observed stretched and bent structure of CO 2 3þ just before Coulomb explosions originates from the structural deformation of CO 2 2þ . We also revealed the mechanism of the experimentally observed bond dissociation of C 2 H 5 OH; we found that the relative probability of C-O bond cleavage to that of C-C bond cleavage becomes smaller with decreases in the pulse length. This example clearly shows that field-induced nonadiabatic transitions play a decisive role in the reaction dynamics of molecules in an intense laser field.

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Section: Multiphoton Ionization and Tunnel Ionizationmentioning

confidence: 99%

Theoretical Investigations of the Electronic and Nuclear Dynamics of Molecules in Intense Laser Fields: Quantum Mechanical Wave Packet Approaches

Kono

Satô

Kanno

et al. 2006

Bulletin of the Chemical Society of Japan

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“…[3][4][5][6][7][8] Laser ionization utilizes the resonanceenhanced multi-photon ionization (REMPI) method, which features molecular selectivity and enables fragment-free ionization. [3][4][5][6][7][8][9][10][11][12][13][14][15][16][17][18][19][20][21][22] The authors of the present report have developed an online monitoring method using ultrasonic jet-type laser ionization TOFMS (time of flight mass spectrometry), and have confirmed the usefulness of this method with respect to PCBs. 8 Because an extremely large number of molecules exist in environmental gas, the requirement is for a method that is for relatively large molecular selectivity in a short time, so as to enable the rapid analysis of trace concentrations.…”

Section: Introductionmentioning

confidence: 76%

Rapid Analysis of Polychlorinated Biphenyls in the Gas Phase with Resonance-enhanced Two-photon Ionization: Optimal Injection of Ions into the Ion-trap Storage/Time-of-flight Mass Spectrometer

et al. 2005

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“…TOF, as used in matrix-assisted laser desorption ionization-time of flight (MALDI-TOF) can access very high m/z values of ~200,000 [47]. TOF mass resolution is improved by incorporation of a reflectron [48]. Resolving power (m/Δm) is very high (~1 × 10 6 ) for FT-ICR detection and enables distinguishing glycans permethylated with 13 CH3 from those permethylated with 12 CH3 [49].…”

Section: Approach In Glycomicsmentioning

confidence: 99%

Development of Monolithic Column Materials for the Separation and Analysis of Glycans

Alla

Stine

2015

Chromatography

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Monolithic column materials offer great advantages as chromatographic media in bioseparations and as solid-supports in biocatalysis. These single-piece porous materials have an interconnected ligament structure that limits the void volume inside the column, thus increasing the efficiency without sacrificing the permeability. The preparation of monolithic materials is easy, reproducible and has available a wide range of chemistries to utilize. Complex, heterogeneous and isobaric glycan structures require preparation methods that may include glycan release, separation and enrichment prior to a comprehensive and site-specific glycosylation analysis. Monolithic column materials aid that demand, as shown by the results reported by the research works presented in this review. These works include selective capture of glycans and glycoproteins via their interactions with lectins, boronic acids, hydrophobic, and hydrophilic/polar functional groups on monolith surfaces. It also includes immobilization of enzymes trypsin and PNGase F on monoliths to digest and deglycosylate glycoproteins and glycopeptides, respectively. The use of monolithic capillary columns for glycan separations through nano-liquid chromatography (nano-LC) and capillary electrochromatography (CEC) and coupling these columns to MS instruments to create multidimensional systems show the potential in the development of miniaturized, high-throughput and automated systems of glycan separation and analysis.

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Reflectron time-of-flight mass spectrometry and laser excitation for the analysis of neutrals, ionized molecules and secondary fragments

Cited by 162 publications

References 70 publications

Theoretical Investigations of the Electronic and Nuclear Dynamics of Molecules in Intense Laser Fields: Quantum Mechanical Wave Packet Approaches

Theoretical Investigations of the Electronic and Nuclear Dynamics of Molecules in Intense Laser Fields: Quantum Mechanical Wave Packet Approaches

Rapid Analysis of Polychlorinated Biphenyls in the Gas Phase with Resonance-enhanced Two-photon Ionization: Optimal Injection of Ions into the Ion-trap Storage/Time-of-flight Mass Spectrometer

Development of Monolithic Column Materials for the Separation and Analysis of Glycans

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