Reflex apnea induced by high-frequency oscillatory ventilation in rabbits

Kohl, J.; Freund, Ute; Koller, E. A.

doi:10.1016/0034-5687(91)90118-3

Cited by 8 publications

(7 citation statements)

References 23 publications

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“…Similar respiratory inhibition reported with endotracheal HFOV has been linked to an increase in vagal pulmonary stretch receptor activity [15] as well as thoracic wall afferent activity [27], which is likely also present in our study. In addition, decreased frequency in HFOV increases tidal volume and alveolar ventilation; the consequent increase in CO 2 elimination [6], even without overt hypocapnia, can induce apnea.…”

Section: Discussionsupporting

confidence: 75%

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Laryngeal Muscle Activity during Nasal High-Frequency Oscillatory Ventilation in Nonsedated Newborn Lambs

et al. 2015

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Background: We have previously shown that nasal pressure support ventilation (nPSV) can lead to an active inspiratory laryngeal narrowing in lambs. This, in turn, can limit lung ventilation and divert air into the digestive system, with potentially deleterious consequences. On the other hand, nasal high-frequency oscillatory ventilation (nHFOV) is particularly attractive in newborns, especially since, unlike nPSV, it does not require synchronization with the patient's inspiratory efforts. Objectives: The main aim of the present study was to test the hypothesis that glottal constrictor muscle activity (EMG) does not develop during nHFOV. A secondary objective was to study laryngeal EMG during nHFOV-induced central apneas. Methods: Polysomnographic recordings were performed in 7 nonsedated lambs which were ventilated with increasing levels of nPSV and nHFOV at both 4 and 8 Hz, in random order. States of alertness, diaphragm and glottal muscle EMG, SpO₂, and respiratory movements were continuously recorded. Results: While phasic inspiratory glottal constrictor EMG appeared with increasing nPSV levels in 6 out of 7 lambs, it was never observed with nHFOV. In addition, nHFOV at 4 Hz dramatically inhibited central respiratory drive in 4/7 lambs, with 64-100% of recording time spent in central apnea in 3 lambs. No glottal constrictor EMG was observed during these central apneas. Conclusion: nHFOV does not induce glottal constrictor muscle EMG in nonsedated newborn lambs, in contrast to nPSV. This may be an additional advantage of nHFOV relative to nPSV.

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Section: Discussionsupporting

confidence: 75%

“…Animal studies have demonstrated that endotracheal HFOV can inhibit spontaneous breathing and induce central apneas [15]. In addition, we have repeatedly shown the consistent presence of active glottal closure throughout central apneas in lambs [16].…”

Section: Introductionmentioning

confidence: 95%

Laryngeal Muscle Activity during Nasal High-Frequency Oscillatory Ventilation in Nonsedated Newborn Lambs

et al. 2015

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“…Likewise, measurements of tissue mechanics at the mean distending pressure during high-frequency oscillatory ventilation in the preterm lamb have identified the point at which optimal lung volume is achieved in the paralyzed preterm lamb (22). As respiratory drive is suppressed during high-frequency oscillatory ventilation (24,25), use of the LFOT coupled with brief airway occlusions in unparalyzed infants may provide the physician with clinically informative lung mechanics at the prevailing lung volume without the need to invoke the Hering-Breuer reflex by further raised volume maneuvers.…”

Section: Discussionmentioning

confidence: 99%

Partitioning of Airway and Parenchymal Mechanics in Unsedated Newborn Infants

Pillow

Stocks²,

Sly

et al. 2005

Pediatr Res

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“…It is known that HFJV in piglets (van Vught et al 1987) and high frequency oscillation ventilation (HFOV) in dogs (Davenport & Dalziel, 1989) and rabbits (Kohl, Freund & Koller, 1991) evoke suppression of spontaneous breathing. These results demonstrated that the major factor suppressing central respiratory activity is the effect of the lung volume increase caused by dynamic PEEP.…”

Section: Discussionmentioning

confidence: 99%

“…This was investigated in more detail by Kohl & Koller (1988) and Kohl et al (1991). Their findings suggested that the apnoea during HFOV in rabbits is mediated mainly by stimulation of SASR and other vagal pulmonary receptors.…”

Section: Discussionmentioning

confidence: 99%

Defensive reflexes of the respiratory system in anaesthetized rabbits during high frequency jet ventilation

Javorka¹,

Kulisek²,

Čalkovská³

1994

Experimental Physiology

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SUMMARYThe defensive airway reflexes during high frequency jet ventilation (HFJV) were studied in anaesthetized, non-vagotomized (n = 16) and vagotomized (n = 11) rabbits. The animals were ventilated by a high frequency jet ventilator. Sneezing and coughing were evoked by mechanical stimulation of the airways. During HFJV spontaneous breathing was inhibited only in the non-vagotomized rabbits. Mechanical stimulation of the airways during HFJV evoked sneezing and coughing, in which the inspiratory component was inhibited. This inhibition occurred not only in defensive reflexes evoked from the regions with increased pressure (trachea, bronchi), but also from the nose. Vagotomy diminished but did not fully eliminate the changes in sneezing accompanying HFJV. The intensity of maximum expiratory efforts was not significantly affected by HFJV in both subgroups.

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Reflex apnea induced by high-frequency oscillatory ventilation in rabbits

Cited by 8 publications

References 23 publications

Laryngeal Muscle Activity during Nasal High-Frequency Oscillatory Ventilation in Nonsedated Newborn Lambs

Laryngeal Muscle Activity during Nasal High-Frequency Oscillatory Ventilation in Nonsedated Newborn Lambs

Partitioning of Airway and Parenchymal Mechanics in Unsedated Newborn Infants

Defensive reflexes of the respiratory system in anaesthetized rabbits during high frequency jet ventilation

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