This article analyzes the environmental aspects of sustainable regional and macroeconomic development, as well as the impact of environmental factors and national environmental projects. The essence of the concept of sustainable development of economic entities in a broad sense is to ensure stable growth of indicators in the environmental, social and economic spheres in the long term. Based on the analysis of the list of indicators of sustainable development, the increasing role of the environmental component is shown. We have identified particularly acute environmental problems that hinder effective sustainable development both at the micro-level (of the organization) and at the macro-level in the whole country and the global community. Based on the calculation of the nature protection, socio-ecological and industrial-ecological indices, the consolidated environmental rating and the place of the Kirov region is determined in it. The analysis of the results of research and the opinions of the World Economic Forum experts on the problems of global threats showed the timeliness and relevance of the national project “Ecology” being implemented in Russia, as well as measures of environmental support and planned environmental projects in the Kirov region. The implementation of the planned measures will activate the catalysts of sustainable development and reduce the risks of negative impact on the environment.