His main areas of interest are medical image processing and analysis, molecular base of ophthalmic disease and pathology pathways, radiological detection, and image-guided therapy. He has considerable experience in biomedical research at Schepens Eye Research Institute, Massachusetts Eye and Ear, with a focus on corneal and ocular surface diseases, and at National Center for Image-Guided Therapy, Brain Tumor Consortium, and BCH Neuroimaging Center on radiological cancer detection at Harvard BWH/ BCH hospitals. Dr. Ziaei's seminal work has been recognized several times. He has published and presented numerous articles in highly ranked peer-reviewed journals and conferences worldwide. Dr. Ziaei has been a scientific member of ARVO, AAO, ISMRM, RSNA, ISBMT, TFOS, and MMS. He serves as an executive editor, an editorial board member, and a scientific reviewer of reputed journals and scientific societies, including