2003
DOI: 10.1182/blood-2002-11-3444
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Refractory anemia in childhood: a retrospective analysis of 67 patients with particular reference to monosomy 7

Abstract: Primary myelodysplasia (MDS) without an increased number of blasts is a rare finding in childhood. We performed a retrospective analysis of 67 children with a diagnosis of primary MDS to determine the clinical and hematologic course of the disease. The median age at diagnosis was 8.3 years (range, 0.3-18.1 years). In contrast to refractory anemia in adults, 44% of patients had hemoglobin levels greater than 10 g/100 mL. The median white blood cell count and the absolute neutrophil count were 3.6 ؋ 10 9 /L and … Show more

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Cited by 152 publications
(142 citation statements)
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“…Neutropenia and thrombocytopenia, but not severe anemia, are reported to be common findings of patients with monosomy 7. 23 Taken together, laboratory findings shown in À5 group and high incidence of the co-presence of À5 and monosomy 7 might result in poor prognosis of the corresponding patients.…”
Section: Discussionmentioning
confidence: 99%
“…Neutropenia and thrombocytopenia, but not severe anemia, are reported to be common findings of patients with monosomy 7. 23 Taken together, laboratory findings shown in À5 group and high incidence of the co-presence of À5 and monosomy 7 might result in poor prognosis of the corresponding patients.…”
Section: Discussionmentioning
confidence: 99%
“…Kardos et al 18 recently reported in 2003 on 67 pediatric patients with refractory anemia. Of these patients, 32 had monosomy 7.…”
Section: Discussionmentioning
confidence: 99%
“…9,12,15 We excluded patients with Down syndrome, previous bone marrow failure both congenital (eg, Fanconi anemia, congenital neutropenia, Diamond-Blackfan anemia, Shwachman-Diamond syndrome), and acquired (aplastic anemia) or therapy-related disease (previous chemo-or radiotherapy).…”
Section: Methodsmentioning
confidence: 99%
“…Hematopoietic stem cell transplantation (HSCT) is the treatment of choice, but the outcome following HSCT is jeopardized if disease progression has occurred. 8,9 Information on prognostic factors predicting progression or death is important in the planning of therapy. There have been few systematic attempts to define a prognostic score in pediatric MDS.…”
Section: Introductionmentioning
confidence: 99%