Regeneration and repair of peripheral nerves

Johnson, Elizabeth O.; Zoubos, Aristides B.; Soucacos, Panayotis N.

doi:10.1016/j.injury.2005.10.012

Cited by 184 publications

(178 citation statements)

References 34 publications

Supporting

Mentioning

141

Contrasting

Unclassified

Order By: Relevance

“…The topographically incorrect regrowth described above is likely to contribute to the incomplete functional recovery seen after nerve section and repair (Diamond and Foerster, 1992;Johnson et al, 2005). This impairment is in accordance with the reduced amplitude of the sensory potentials from the digits described after sciatic nerve injury and repair (Puigdellívol-Sánchez et al, 2002;Negredo et al, 2004).…”

Section: Regenerative Sproutingsupporting

confidence: 60%

Estimations of topographically correct regeneration to nerve branches and skin after peripheral nerve injury and repair

Puigdellı́vol-Sánchez

Prats-Galino

Molander

2006

Brain Research

View full text Add to dashboard Cite

Peripheral nerve injury is typically associated with long-term disturbances in sensory localization, despite nerve repair and regeneration. Here we investigate the extent of correct reinnervation by back-labeling neuronal soma with fluorescent tracers applied in the target area before and after sciatic nerve injury and repair in the rat. The subpopulations of sensory or motor neurons that had regenerated their axons to either the tibial branch or the skin of the third hindlimb digit were calculated from the number cell bodies labeled by the first and/or second tracer. Compared to the normal control side, 81% of the sensory and 66% of the motor tibial nerve cells regenerated their axons back to this nerve, while 22% of the afferent cells from the third digit reinnervated this digit. Corresponding percentages based on quantification of the surviving population on the experimental side showed 91%, 87%, and 56%, respectively. The results show that nerve injury followed by nerve repair by epineurial suture results in a high but variable amount of topographically correct regeneration, and that proportionally more neurons regenerate into the correct proximal nerve branch than into the correct innervation territory in the skin. SECTION: 4. Nervous System Development, Regeneration and Aging.

show abstract

Section: Regenerative Sproutingsupporting

confidence: 60%

Estimations of topographically correct regeneration to nerve branches and skin after peripheral nerve injury and repair

Puigdellı́vol-Sánchez

Prats-Galino

Molander

2006

Brain Research

View full text Add to dashboard Cite

show abstract

“…However, other alternatives are considered in cases of nerve segmental loss with a consequent gap longer than 2 cm because of the tension that emerges when two ends are sutured to each other (Johnson et al 2005 ). Nerve grafting or nerve conduits are standard procedure in cases like these (Siemionow and Brzezicki 2009 ;Pabari et al 2010 ).…”

Section: Biomaterials Design For Peripheral Nerve Repairmentioning

confidence: 99%

Bioactive Nanomaterials for Neural Engineering

et al. 2016

View full text Add to dashboard Cite

“…Although crush injuries are considered less severe than transection injuries, the axon distal to the injury site in both cases degenerates (Sunderland, 1951). However, unlike transection injuries, the connective tissue elements remain in continuity after crushing, which provides guidance for axonal sprouts from the regenerating central stump (Sunderland, 1951;Johnson et al, 2005). Injury to the LN is associated with changes in the epithelium of the tongue, particularly in the differentiation of the papillae and taste buds.…”

Section: The Injury Of the Lingual Nerve (Ln)mentioning

confidence: 99%