2020
DOI: 10.1002/jper.20-0110
|View full text |Cite
|
Sign up to set email alerts
|

Regeneration of critical‐sized mandibular defect using a 3D‐printed hydroxyapatite‐based scaffold: An exploratory study

Abstract: Background: Three-dimensional (3D) printing has become an available technology to fabricate customized tissue engineering scaffolds with delicate architecture. This exploratory study aimed to evaluate the potential of a 3D-printed hydroxyapatite-based scaffold as a biomaterial for obtaining guided bone regeneration (GBR) in vivo. Methods: Scaffolds composed of 90% hydroxyapatite and 10% poly(lactic-coglycolic acid) were printed using a microextrusion process to fit 4 mm diameter and 0.5 mm thick through-and-th… Show more

Help me understand this report

Search citation statements

Order By: Relevance

Paper Sections

Select...
3
1
1

Citation Types

1
58
0

Year Published

2021
2021
2024
2024

Publication Types

Select...
6
1

Relationship

0
7

Authors

Journals

citations
Cited by 24 publications
(59 citation statements)
references
References 27 publications
1
58
0
Order By: Relevance
“…Since ALDH2 plays a crucial role in the clearance of toxic acetaldehyde derived from alcohol drinking and the ALDH2 mutation may cause severe bony defects, therefore, we provided drinking water with 10% alcohol to all animals in this study. Porphyromonas gingivalis is a well-known periodontal pathogen and is one of the predominant species in the gingival pockets of patients with advanced and severe periodontal disease [ 22 , 23 ]. It is mostly found in the deep periodontal pockets and active sites [ 34 , 35 ].…”
Section: Discussionmentioning
confidence: 99%
See 1 more Smart Citation
“…Since ALDH2 plays a crucial role in the clearance of toxic acetaldehyde derived from alcohol drinking and the ALDH2 mutation may cause severe bony defects, therefore, we provided drinking water with 10% alcohol to all animals in this study. Porphyromonas gingivalis is a well-known periodontal pathogen and is one of the predominant species in the gingival pockets of patients with advanced and severe periodontal disease [ 22 , 23 ]. It is mostly found in the deep periodontal pockets and active sites [ 34 , 35 ].…”
Section: Discussionmentioning
confidence: 99%
“…Micro-CT imaging protocol was as described in our previous study [ 22 ]. To obtain micro-CT images, upon animal sacrifice, samples of upper jaws of all mice were collected, trimmed, and fixed in 10% formalin solution for at least three days.…”
Section: Methodsmentioning
confidence: 99%
“…1A). It was then sliced and outputted by a extrusion-based bioprinter, with ink composed of 90 wt% hydroxyapatite and 10 wt% 82:18 poly(lactic-co-glycolic acid), as described previously (Chang et al 2020). The dimensions, interconnectivity, and porosity of the scaffold were measured from the top view and cross-sectional view of scanning electron microscopic images with image processing software.…”
Section: Methodsmentioning
confidence: 99%
“…Images were then reconstructed and oriented to identify a 4-mm-diameter and 0.5-mm-thickness region as the radiographic region of interest, with the region covered by the lid compartment of the scaffold excluded. The following paramters within the radiographic region of interest (TV) were assessed by CT Analyzer software as previously described (Chang et al 2020): bone volume (BV; newly formed bone [NB] only) and mineralized tissue volume (MV; residual scaffold and NB).…”
Section: Methodsmentioning
confidence: 99%
See 1 more Smart Citation