Regeneration of Injured Renal Tubules

Yoshida, Makoto; Honma, Shigeyoshi

doi:10.1254/jphs.13r12cp

Cited by 31 publications

(15 citation statements)

References 37 publications

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“…Dedifferentiation of injured tubular cells [following detachment of injured epithelium] the basement membrane of tubules is covered by mesenchymal cells that repair tubular damage (3). Immigration of bone marrow derived cells to the kidney and participates in renal regeneration [34]. These results are confirmed with other research that showed the protective impact of E. sativa against nephrotoxicity [35] [36].…”

Section: Discussionsupporting

confidence: 85%

Eruca sativa and Raphanus sativus oils Enhance Hepatic and Renal Tissues Regeneration in White Mice

Kamil¹

2019

MJS

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Regeneration is a process of tissue repairing in the body, and according to this process the cells of the body are divided into three types; labile, stable and permanent cells. Objectives: The aims of this study are to evaluate the ability of two herbal seed oils (Eruca sativa and Raphanus sativus) to enhance regeneration and repair in the liver and kidney in the irradiated mice. And to investigate which herbal oil is more effective. Method: Four groups of mice were used in this study. The first three groups were exposed to radiation while the fourth was used as a control. After irradiation the first and second groups were treated with local Eruca sativa and Raphanus sativus oils respectively. While the third group used as a control. Then histopathological investigation was done. Results: Histopathological examination in irradiated groups exhibited that both seed oils could induce regeneration in both hepatic and renal tissues but the activity of Raphanus sativus oil was more effective than Eruca sativa especially in renal tissue. Meanwhile, poor regeneration process appeared in the third group (control). Conclusion: Both local herbal oils had ability to enhance regeneration in the examined tissues but R. sativus seed oil exerted more activity than E. sativa seed oil.

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Section: Discussionsupporting

confidence: 85%

Eruca sativa and Raphanus sativus oils Enhance Hepatic and Renal Tissues Regeneration in White Mice

Kamil¹

2019

MJS

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“…Tozzi et al outlined how PP significantly reduces tissue antigen expression of soluble intracellular adhesion molecule-1 (sICAM-1) and pro-inflammatory cytokine (TNFα, IL-2 and IL-1β) compared to SCS controls, resulting in the reduction of leucocyte stimulation (particular neutrophils) and a decrease in postreperfusion activated inflammation-mediated acute-phase proteins that are responsible for ischemia/reperfusion injury (IRI). Many authors have stressed the correlation between IRI, cell apoptosis, delayed graft function (DGF) and chronic renal failure [22,23]. Apoptosis is a reversible programmed cell death [24].…”

Section: Dynamic Perfusion Apoptosis and Inflammationmentioning

confidence: 99%

Pulsate Perfusion of Allografts

Tozzi

Piffaretti

Franchin

et al. 2019

Visceral Vessels and Aortic Repair

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“…Recovery from ischemic and nephrotoxic AKI depends on regeneration of damaged tubular cells. Renal stem or progenitor cells outside the nephron migrate into the damaged nephrons and then regenerate the tubules (1,2). Several studies suggest that there is a very delicate and dynamic relationship between tissue repair and progression or regression of renal injury (2).…”

Section: öZmentioning

confidence: 99%

Hypothyroidism as an Obstacle to the Resolution of Acute Kidney Injury

Yıldız¹,

Oruç²,

Gül³

et al. 2016

Turk Neph Dial Transpl

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We described the clinical course of 4 patients with acute kidney injury (AKI) in whom kidney function improvement was delayed because of concomitant hypothyroidism. After initiating thyroid hormone replacement therapy, the kidney function improved partially or completely. We discussed the underlying possible pathophysiological mechanisms of delayed recovery. A 33-year-old female presented with kidney failure following severe preeclampsia. She was diagnosed with hypothyroidism. The second case was a 70-year-old male who was healthy previously, and presented with elevated serum creatinine. The third patient was a 72-year-old female, who was admitted with non-oliguric AKI associated with aminoglycoside and non-steroid anti-inflammatory drug exposure. The fourth patient was a 60-yearold female under amiodarone treatment after coronary bypass grafting who presented with fatigue, and AKI. We suggest that delayed recovery of kidney dysfunction might be associated with hypothyroidism that prevents regeneration of tubular cells. KEY wORdS: Acute kidney injury, Hypothyroidism, Thyroid hormone replacement therapy ÖzAkut böbrek hasarının (ABH) mortalite ve morbiditesi yüksektir. Eşlik eden sistemik hastalık varlığında iyileşmesi zorlaşır ve gecikir. Hipotiroidi, tanı konulmadığı ve tedavi edilmediği durumda ABH iyileşmesini engelleyebilir. Eşlik eden hipotiroidi nedeni ile iyileşmesi geciken 4 ABH olgusunu takdim ettik. İlk olgu olan, ciddi pre-eklampsi sonrası ABH gelişen 33 yaşındaki kadın hastada hipotiroidi tespit edildi. İkinci olgu hiçbir sistemik hastalığı olmayan 70 yaşında bir erkek, diğeri ise aminoglikozid ve non-steroid anti inflamatuvar ilaç kullanımına bağlı non-oligürik ABH gelişen 72 yaşında kadın hastaydı. Son olgu ise koroner bypass operasyonu sonrası amiodaron tedavisi altında ABH ile başvuran 60 yaşında kadın hastaydı. Tüm hastalarda, eşlik eden hipotiroidi tespit edildi. Tiroid hormon replasman tedavisi başlandı ve sonrasında ABH tam ya da kısmi olarak iyileşti. Yazımızda ABH iyileşmesinin gecikmesinde hipotiroidi ile ilişkili olabilecek patofizyolojik mekanizmalar tartışıldı. Hipotiroidism, tübüler hücrelerin rejenerasyonunu engelleyerek böbrek fonksiyonlarının iyileşmesinin gecikmesine neden olabilir. Ayrıca tedavi edilmediği durumlarda ABH iyileşmesini engelleyebilir.

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Regeneration of Injured Renal Tubules

Cited by 31 publications

References 37 publications

Eruca sativa and Raphanus sativus oils Enhance Hepatic and Renal Tissues Regeneration in White Mice

Eruca sativa and Raphanus sativus oils Enhance Hepatic and Renal Tissues Regeneration in White Mice

Pulsate Perfusion of Allografts

Hypothyroidism as an Obstacle to the Resolution of Acute Kidney Injury

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