Regeneration of periodontal tissue by bone morphogenetic protein-treated DNA/atelocollagen in beagle dogs.

Murata, Masaru; Sato, Daisuke; Tomoya, Sasaki; Taira, Hirohiko; Arisue, Makoto

doi:10.5794/jjoms.49.1

Cited by 1 publication

(1 citation statement)

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“…Manipulating the composition of BC could generate new material that is even safer and more effective in the long term. Moreover, further clinical study may involve higher animals, such as dogs or monkeys [54,55]. We believe that BC has a bright future, and will serve as an excellent biomaterial for tissue engineering.…”

Section: Discussionmentioning

confidence: 99%

Efficacy of Bacterial Cellulose as a Carrier of BMP-2 for Bone Regeneration in a Rabbit Frontal Sinus Model

et al. 2019

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If the alveolar bone height of patients requiring dental implants in the maxillary molar region is inadequate, it is difficult to achieve satisfactory outcomes using existing bone graft materials. We previously reported the possible utility of bacterial cellulose (BC) as a new dental treatment material. BC has a high absorptive capacity, good mechanical strength, and good volume retention. BC loaded with bone morphogenetic protein-2 (BMP-2) might allow effective alveolar bone augmentation. We created critical frontal bone defect models in 12 male Japanese white rabbits and divided them into four groups: sham; BC (BC grafting only); BMP-2 (treated with BMP-2 solution only); and BC+BMP-2 (grafted with BC loaded with BMP-2). Newly formed bone volume was calculated via hematoxylin-eosin staining evaluation. The proliferating cell nuclear antigen and osteocalcin levels were determined by the immunohistochemical staining analysis. All measured indices of the BC+BMP-2 group were significantly superior to those of the other groups (all p < 0.05). BC maintained the graft space and released BMP-2 in a sustained manner, promoting optimal bone formation. The BC+BMP-2 combination enhanced bone regeneration and shows promise as a useful means of clinical pre-dental implant bone augmentation in the maxillary sinus.

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Section: Discussionmentioning

confidence: 99%