Regeneration of the Lens in the Amphibian Eye

Fibroblast growth factor receptors and regeneration of the eye lens

“…For example, regeneration of the lens of the eye is restricted to a small number of urodeles (tailed amphibia). One of these, the Eastern (U.S.) spotted newt, Notophthalmus viridescens, is easily obtainable and has been the subject of research in regeneration of adult eye tissues for most of this century (Reyer, 1954;McDevitt and Brahma, 1982b;Yamada and McDevitt, 1984;McDevitt, 1989). When the lens is removed, a new lens will form at the margin of the dorsal iris only; in situ, the ventral iris will not regenerate a lens.…”

In vivo study of lens regeneration in Rana cyanophlyctis under influence of vitamin A and ascorbic acid

“…Lens regeneration from non ocular tissue (dorsal iris) has been well documented in urodele amphibians (Reyer, 1977(Reyer, , 1954Eguchi and Itoh, 1982;Eguchi, 1988). However, recently it has been observed that the capability of retinal iris PECs to transdifferentiate into lens is not restricted to urodeles amphibians only but is widely conserved in almost all vertebrates (Okada, 2000;Jangir et al, 2000Jangir et al, , 2001Jangir et al, , 2005Acharya et al, 2003;Shekhawat et al, 2001).…”

Electron Microscopic Studies on Lens Regeneration

“…This can be regarded as one of the structural bases for our recent biochemical findings on the dorsal predominance in the activity of phosphorus metabolism of the iris (EGUCHI andISHIKAWA 1960 and, cf. P a s A L A K Y et al 1951 andOGAWA, 1962). Furthermore, it has been known by the experiment of TAKAHASHI (1930) that the mid-dorsal part of the iris is the most active in developmental movement and growth of the eye (cf.…”