Regenerative effects of peptide nanofibers in an experimental model of Parkinson’s disease

Sever, Melike; Turkyilmaz, Mesut; Sevinc, Cansu; Çakır, Ayşen; Öcalan, Büşra; Cansev, Mehmet; Güler, Mustafa O.; Tekinay, Ayşe B.

doi:10.1016/j.actbio.2016.09.011

Cited by 21 publications

(10 citation statements)

References 42 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…This indicates that HOTAIRM1 upregulation may be responsible for the inflammatory cytokine expression in leukocytes (Supplementary Figure 3). We also examined the expression of the four lncRNAs in SH-SY5Y cells stimulated with 6-OHDA, an in vitro system often used in PD study (Sever et al, 2016). Consistent with our findings in PD patients, AC131056.3-001, HOTAIRM1, and RF01976.1-201 expression were significantly increased in SH-SY5Y cells after 6-OHDA stimulation (Figure 7D).…”

Section: Upregulation Of Lncrnas In Human Monocytic and Neuroblastomasupporting

confidence: 83%

Dysregulated Long Non-coding RNAs in Parkinson’s Disease Contribute to the Apoptosis of Human Neuroblastoma Cells

Fan

Yang

et al. 2019

Front. Neurosci.

View full text Add to dashboard Cite

The molecular mechanism underlying Parkinson's disease (PD), an increasingly common neurodegenerative disease, remains unclear. Long non-coding RNA (lncRNA) plays essential roles in gene expression and human diseases. We hypothesize that lncRNAs are involved in neuronal degeneration of PD. Using microarray, we identified 122 differentially expressed (DE) lncRNAs and 48 DE mRNAs between the circulating leukocytes from PD patients and healthy controls. There were 714 significant correlations (r ≥ 0.8 or ≤−0.8, p < 0.05) among the DE lncRNAs and mRNAs. Gene function and pathway analysis of the 48 DE mRNAs revealed biological pathways related to PD pathogenesis, including immune response, inflammatory response, MAPK, and Jak-STAT pathway. In a cohort of 72 PD patients and 22 healthy controls, the upregulation of four lncRNAs (AC131056.3-001, HOTAIRM1, lnc-MOK-6:1, and RF01976.1-201) in circulating leukocytes of PD patients were further confirmed. These lncRNAs were also upregulated in THP-1 cells, a human monocytic cell line, after inflammatory stimulation. Interestingly, the conditioned culture medium of THP-1 cells or 6-OHDA significantly increased the expression of these lncRNAs in SH-SY5Y cells, a human neuroblastoma cell line expressing dopaminergic markers. Importantly, overexpression of AC131056.3-001 or HOTAIRM1 increased baseline and 6-OHDAinduced apoptosis of SH-SY5Y cells. Taken together, we identified distinct expression profiles of lncRNA and mRNA in circulating leukocytes between PD patients and healthy controls. Dysregulated lncRNAs such as HOTAIRM1 and AC131056.3-001 may contribute to PD pathogenesis by promoting the apoptosis of dopaminergic neuron.

show abstract

Section: Upregulation Of Lncrnas In Human Monocytic and Neuroblastomasupporting

confidence: 83%

Dysregulated Long Non-coding RNAs in Parkinson’s Disease Contribute to the Apoptosis of Human Neuroblastoma Cells

Fan

Yang

et al. 2019

Front. Neurosci.

View full text Add to dashboard Cite

show abstract

“…[52][53][54] Furthermore, it has been reported that carbon nanotubes induced fibrogenesis on nanostructured substrates. 55 Moreover, nanoparticles are 100 times smaller than normal red blood cells, which increase the potential for interaction, and there is evidence that nanoparticles interact with proteins, DNA, 56 lung cells, and viruses. The current assumption is that nanoparticles such as silica featured as hydrophilic, hydrophobic, or even amphiphilic that can be taken up by human membranes may pose serious threats.…”

Section: Introduction Of Nanoparticlesmentioning

confidence: 99%

Impact of nanoparticles on neuron biology: current research trends

Khan

Almohazey

Alomari

et al. 2018

IJN

View full text Add to dashboard Cite

Nanoparticles have enormous applications in textiles, cosmetics, electronics, and pharmaceuticals. But due to their exceptional physical and chemical properties, particularly antimicrobial, anticancer, antibacterial, anti-inflammatory properties, nanoparticles have many potential applications in diagnosis as well as in the treatment of various diseases. Over the past few years, nanoparticles have been extensively used to investigate their response on the neuronal cells. These nanoparticles cause stem cells to differentiate into neuronal cells and promote neuronal cell survivability and neuronal cell growth and expansion. The nanoparticles have been tested both in in vitro and in vivo models. The nanoparticles with various shapes, sizes, and chemical compositions mostly produced stimulatory effects on neuronal cells, but there are few that can cause inhibitory effects on the neuronal cells. In this review, we discuss stimulatory and inhibitory effects of various nanoparticles on the neuronal cells. The aim of this review was to summarize different effects of nanoparticles on the neuronal cells and try to understand the differential response of various nanoparticles. This review provides a bird’s eye view approach on the effects of various nanoparticles on neuronal differentiation, neuronal survivability, neuronal growth, neuronal cell adhesion, and functional and behavioral recovery. Finally, this review helps the researchers to understand the different roles of nanoparticles (stimulatory and inhibitory) in neuronal cells to develop effective therapeutic and diagnostic strategies for neurodegenerative diseases.

show abstract

“…The researchers observed that the scaffold was well tolerated and could maintain the cells alive for an extended period . Peptide amphiphiles scaffolds made from lamin and heparan sulfate possesses the quality of being ECM mimetic have also showed potential as PD treatment moderators …”

Section: Tissue Engineering Scaffolds For Alzheimer’s and Parkinson'smentioning

confidence: 99%

Tissue engineering scaffolds in the treatment of brain disorders in geriatric patients

et al. 2019

View full text Add to dashboard Cite

The world population is ageing at an alarming rate, currently increasing at around 3% per year for people over 60 years. This fast growing demography is largely unproductive and prone to many brain disorders such as Alzheimer's disease, Parkinson's disease, and brain tumors. Currently available treatment modalities are inadequate to stop neural degeneration or to completely eradicate cancer cells. Exogenously engineered scaffolds hold great potential for in vivo brain regeneration and functional restoration.

show abstract

Regenerative effects of peptide nanofibers in an experimental model of Parkinson’s disease

Cited by 21 publications

References 42 publications

Dysregulated Long Non-coding RNAs in Parkinson’s Disease Contribute to the Apoptosis of Human Neuroblastoma Cells

Dysregulated Long Non-coding RNAs in Parkinson’s Disease Contribute to the Apoptosis of Human Neuroblastoma Cells

Impact of nanoparticles on neuron biology: current research trends

Tissue engineering scaffolds in the treatment of brain disorders in geriatric patients

Contact Info

Product

Resources

About