Regenerative Endodontic Management of an Immature Molar Using Calcium Hydroxide and Triple Antibiotic Paste: a Two-Year Follow-Up

Alasqah, Mohannad; Khan, Sulthan Ibrahim Raja; Alfouzan, Khalid; Jamleh, Ahmed

doi:10.1155/2020/9025847

Cited by 14 publications

(16 citation statements)

References 36 publications

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“…It confirmed a normal periapical tissue and complete roots formation. A positive response to cold test was obtained after 3 years and this is similar to another study's finding in which the authors reported a positive response to cold in an immature molar tooth with a coronal MTA plug [34].…”

Section: Discussionsupporting

confidence: 89%

Revascularization of an Immature Necrotic Mandibular Second Molar Using Calcium Hydroxide: A 3-year Follow Up

Alsalhi¹,

Alkatheeri²

2021

IJDSR

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Endodontic intervention in necrotic immature permanent teeth is usually a clinical challenge. With appropriate case selection and optimal disinfection, regenerative endodontic procedure (REP) can be effective and a desirable result can be obtained. In this report, an immature necrotic mandibular second molar had been treated by REP in two visits. In the first visit, a nonsetting calcium hydroxide was used as intracanal medication after irrigation with 1.5% (NaOCl). In the second visit, blood clots were created in the root canals. MTA was placed over the blood clots and the tooth was restored with a composite filling and stainless-steel crown. A clinical and radiographic follow up was performed for three years where the tooth was deemed a symptomatic with a complete root formation.

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Section: Discussionsupporting

confidence: 89%

Revascularization of an Immature Necrotic Mandibular Second Molar Using Calcium Hydroxide: A 3-year Follow Up

Alsalhi¹,

Alkatheeri²

2021

IJDSR

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“…The search culminated in forty-six studies that fulfilled both the inclusion and exclusion criteria. The review included randomized controlled trials, controlled clinical trials, case reports, in vitro with in vivo studies, in vivo studies, and prospective/retrospective studies comparing the effectiveness of pulp revascularization in immature necrotic permanent teeth [ 3 , 4 , 6 , 16 , 20 , 22 , 26 – 65 ]. The studies included in this systematic review were 31 human studies [ 3 , 4 , 6 , 16 , 20 , 22 , 26 – 31 , 35 , 39 , 40 , 44 – 47 , 50 – 53 , 55 – 57 , 59 , 60 , 63 – 65 ] and 15 animal studies [ 32 – 34 , 36 – 38 , 41 – 43 , 48 , 49 , 54 , 58 , 61 , 62 ].…”

Section: Resultsmentioning

confidence: 99%

“…This systematic review evaluated 46 studies that included a study sample of 1006 subjects (teeth). The human studies included patients of children and young individuals (aged between 7 and 18 years) with a mean age (mean ± SD) 10.1 ± 3.18 years and selected from different dental clinics, hospitals, and dental schools [ 3 , 4 , 6 , 16 , 20 , 22 , 26 – 31 , 35 , 39 , 40 , 44 – 47 , 50 – 53 , 55 – 57 , 59 , 60 , 63 – 65 ]. On the other hand, most of the samples in animal studies included different species such as ferrets, sheep, dogs, and monkeys [ 32 – 34 , 36 – 38 , 41 – 43 , 48 , 49 , 54 , 58 , 61 , 62 ].…”

Section: Resultsmentioning

confidence: 99%

“…Among the included studies, six studies illustrated negative outcomes in regard to endodontic regeneration therapy in the management of immature necrotic permanent teeth [ 29 , 34 , 46 , 48 , 49 , 54 ]. On the other hand, 40 studies showed significant positive outcomes for endodontic regeneration treatment in these kinds of teeth due to root development, root wall thickening, root lengthening, and formation of hard tissue barrier or apical closure [ 3 , 4 , 6 , 16 , 20 , 22 , 26 – 28 , 30 – 33 , 35 – 45 , 47 , 50 – 53 , 55 – 65 ]. The outcomes of these 46 studies include different types of intracanal medications, scaffolds, pulpal space/barrier, root maturation stage, follow-up duration, and updating studies on their effect in periapical periodontitis and periapical healing.…”

Section: Resultsmentioning

confidence: 99%

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Regenerative Endodontic Therapy in the Management of Immature Necrotic Permanent Dentition: A Systematic Review

Alghamdi

Alqurashi

2020

The Scientific World Journal

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Background and Objective. Management of immature permanent teeth exhibiting necrotic pulp is clinically challenging. An appropriate diagnosis, case selection, and good management ensure good outcomes. The objective of this review reviews all up-to-date data in regard to endodontic regeneration therapy in the management of immature permanent teeth with necrotic pulp and which conducts are most used and appropriate for this procedure in human and animal investigations. Materials and Methods. The electronic databases PubMed and Google Scholar were used to search the literature for relevant studies after applying specific inclusion and exclusion criteria. Studies that fulfilled both the inclusion and exclusion criteria were included in this systematic review. The search was conducted by two independent reviewers following the PRISMA guidelines. Results. Only 46 studies that fulfilled both the inclusion and exclusion criteria, which were conducted within the last 10 years, were included in this systematic review. These studies investigated different aspects of regenerative endodontic therapy including different types of scaffolds, intracanal medications, pulpal space/barriers, root maturation stage, follow-up duration, and updated studies on their use in the management of immature necrotic permanent teeth. Conclusions. This review concluded the compiled data observed that endodontic regenerative therapy was more efficient in treating immature necrotic permanent teeth and offered a greater advantage that should lead to wider acceptance among endodontists for effective results compared to different treatment options. However, more clinical trials with a standardized protocol and defined clinical, radiographic, and histopathological outcomes with longer follow-up periods are warranted.

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“…If TAP is to be used for ERP, it should be employed at a concentration of 1–5 mg/mL as recommended/prescribed by the “American Association of Endodontists” [ 6 , 8 ]. Furthermore, other materials and systems have been considered for ERP to achieve root canal disinfection, namely, calcium hydroxide as an intracanal medicament [ 8 , 9 ] and the newly devised three-dimensional drug delivery construct, which seems to be a promising potential as a disinfection strategy for RE [ 10 ].…”

Section: Introductionmentioning

confidence: 99%

An Innovative Drug Delivery System Loaded with a Modified Combination of Triple Antibiotics for Use in Endodontic Applications

Parhizkar

Nojehdehian

Tabatabaei

et al. 2020

International Journal of Dentistry

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The objective of the current study was to introduce “Polylactic co-Glycolic Acid- (PLGA-) Coated Ceramic Microparticles” as an innovative drug delivery system, loaded with a new combination of triple antibiotics (penicillin G, metronidazole, and ciprofloxacin (PMC)) for use in endodontic treatments. Ceramic microparticles were made from β-tricalcium phosphate and hydroxyapatite and examined by “Scanning Electronic Microscope (SEM).” Then, fixed amounts of the selected antibiotics were added to a prepared PLGA solution and stirred thoroughly. Next, the prepared ceramic microparticles were dispersed completely in the drugs solution. The deposited “PMC-loaded PLGA-coated ceramic microspheres (PPCMs)” were dried and incubated in phosphate buffer saline (PBS) for 21 days. The drug release from PPCMs was quantified by a UV spectrophotometer. The antimicrobial activity of PPCMs was investigated using the “Agar Plate Diffusion Test (ADT),” “Minimum Inhibitory Concentration (MIC),” and “Minimum Bactericidal Concentration (MBC)” against Enterococcus faecalis (E. faecalis) and Aggregatibacter actinomycetemcomitans (A.a). The cell viability test (MTT) was conducted for cytotoxicity against human gingival fibroblasts. SEM micrographs of PPCMs showed spherical-like ceramic microparticles with smooth surfaces. Crystal-like antibiotic particles (chunks) were also found on PPCMs. Initial burst of antibiotics (31 µg/mL, 160 µg/mL, and 18 µg/mL for ciprofloxacin, metronidazole, and penicillin G, respectively, in the first 4 days) followed by gradual and sustained release was observed within a period of 21 days. PPCMs demonstrated pH close to normal physiological environment and antibacterial activity against E. faecalis and A.a in the first 2 days. MTT showed cell viability of more than 70% for PPCMs after 24 h and 72 h of exposure. In conclusion, PPCMs demonstrated satisfactory release of antibiotics, antibacterial activity against the selected microorganisms, and biocompatibility. Thus, PPCMs may be used to deliver modified triple antibiotics to the root canal system for use in endodontic applications.

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Regenerative Endodontic Management of an Immature Molar Using Calcium Hydroxide and Triple Antibiotic Paste: a Two-Year Follow-Up

Cited by 14 publications

References 36 publications

Revascularization of an Immature Necrotic Mandibular Second Molar Using Calcium Hydroxide: A 3-year Follow Up

Revascularization of an Immature Necrotic Mandibular Second Molar Using Calcium Hydroxide: A 3-year Follow Up

Regenerative Endodontic Therapy in the Management of Immature Necrotic Permanent Dentition: A Systematic Review

An Innovative Drug Delivery System Loaded with a Modified Combination of Triple Antibiotics for Use in Endodontic Applications

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