Regenerative Endodontic Procedure of Immature Permanent Teeth with Leukocyte and Platelet-rich Fibrin: A Multicenter Controlled Clinical Trial

Meschi, Nastaran; EzEldeen, Mostafa; Garcia, Andres Eduardo Torres; Lahoud, Pierre; Gorp, G. Van; Coucke, Wim; Jacobs, Reinhilde; Vandamme, Katleen; Teughels, Wim; Lambrechts, Paul

doi:10.1016/j.joen.2021.08.003

Cited by 26 publications

(42 citation statements)

References 70 publications

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“…Considering the discoloration potential of blood per se and the role of it in intensifying the discoloration caused by HCSCs [5], alternative sca olds may be preferred in RETs, provided that they meet the criteria of an ideal sca old. Sca olds such as platelet-rich brin (PRF) and platelet-rich plasma (PRP) have been associated with favorable and successful results in previous studies [38][39][40][41][42][43]. Although PRF has been addressed as an ideal purely autologous sca old for regeneration [44,45], there is not enough evidence available to substitute blood clot with another sca old.…”

Section: Discussionmentioning

confidence: 99%

Evaluation of the Effectiveness of Laser-Assisted Bleaching of the Teeth Discolored due to Regenerative Endodontic Treatment

Shokouhinejad

Khoshkhounejad

Hamidzadeh

2022

International Journal of Dentistry

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Regenerative endodontic treatments (RETs) as a valuable treatment option to save the immature necrotic teeth, have been reported to be associated with discoloration which is an inevitable unfavorable outcome. The present study aimed to compare three laser-assisted protocols with conventional walking bleaching in terms of bleaching efficacy. Seventy-two human incisor teeth underwent regenerative treatment. A triple antibiotic paste containing minocycline, ciprofloxacin, and metronidazole was used as an intracanal medicament. A human blood clot was applied as a scaffold and capped by a hydraulic calcium silicate-based cement. Ten weeks after the RET procedure, a four-session bleaching course started. Teeth were assigned to four groups: (1) 35% hydrogen peroxide gel, (2) 35% hydrogen peroxide gel + Nd: YAG laser, (3) 35% hydrogen peroxide gel + 980 nm diode laser, and (4) 35% hydrogen peroxide gel + 810 nm diode laser. The color changes (ΔE) were measured before and after bleaching sessions. The data were analyzed using Kruskal–Wallis nonparametric test. The statistical significance level was set at 0.05. Significant discoloration, exceeding the perceptibility threshold (ΔE > 3.7) was observed in all of the samples ten weeks after RET. There was no significant difference between groups in terms of RET-induced discoloration values ( p > 0.05 ). Bleaching either by using 35% hydrogen peroxide or 35% hydrogen peroxide activated by different lasers used in this study resulted in significant tooth whitening ( p < 0.05 ). There was no statistically significant difference among the groups in terms of bleaching efficacy ( p > 0.05 ). Internal bleaching by using 35% hydrogen peroxide is as effective as laser-assisted protocols for correction of crown discoloration in teeth that have undergone RET.

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Section: Discussionmentioning

confidence: 99%

Evaluation of the Effectiveness of Laser-Assisted Bleaching of the Teeth Discolored due to Regenerative Endodontic Treatment

Shokouhinejad

Khoshkhounejad

Hamidzadeh

2022

International Journal of Dentistry

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“…In recent years, L-PRF has been used as a biomaterial scaffold in REPs in an immature permanent tooth in association with apical surgery [ 106 ] or in autologous DPSCs therapy for a mature permanent tooth with symptomatic irreversible pulpitis [ 113 ]. A multicenter controlled clinical trial was recently reported to evaluate the effect of L-PRF on REPs of immature permanent teeth [ 114 ]. Twenty-nine patients between 6 and 25 years with an inflamed or necrotic immature permanent tooth were included and divided into the test group (REPs with L-PRF) and control group (REPs without L-PRF).…”

Section: Host-derived Biomaterials Scaffoldsmentioning

confidence: 99%

“…Collagen possesses complex supramolecular structure, which provides a highly organized structural and biological framework [ 122 ]. Collagen has the potential to be used as a biomaterial in tissue engineering because of its biocompatible and biodegradable properties [ 113 , 114 ]. To date, different collagen-based scaffolds have been used for dental pulp regeneration, including pure collagen scaffolds (i.e., collagen sponge, pellet and membrane), collagen-based scaffolds combined with other natural or synthetic material, as well as composite scaffolds comprising collagen, growth factors or stem cells [ [115] , [116] , [117] , [118] , [119] , [120] , [121] , [122] , [123] , [124] , [125] , [126] , [127] , [128] ].…”

Section: Natural Biomaterials Scaffoldsmentioning

confidence: 99%

Biomaterial scaffolds for clinical procedures in endodontic regeneration

Liu

Lü

Jiang

et al. 2022

Bioactive Materials

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“…Thirty-two articles were included in this study (Table 3). Eighteen articles [16][17][18][19][20][21][22][23][24][25][26][27][28][29][30][31][32][33] evaluated the clinical outcome of regenerative endodontic procedures (REP) and five articles [34][35][36][37][38] on the apexification procedure. Only nine articles [39][40][41][42][43][44][45][46][47] evaluated and compared the clinical outcome between regeneration and apexification procedure.…”

Section: Designmentioning

confidence: 99%

“…In total, of the 18 articles [16][17][18][19][20][21][22][23][24][25][26][27][28][29][30][31][32][33] evaluating regeneration outcomes, 14 articles [16][17][18][19][20][21][22][23][24][25][26][27][28]33] were randomized clinical trials, and 4 articles [29][30][31][32] were non-randomized clinical articles. In randomized clinical trials, a total of 393 participants and 412 teeth were included.…”

Section: Participantsmentioning

confidence: 99%

Clinical Outcome and Comparison of Regenerative and Apexification Intervention in Young Immature Necrotic Teeth—A Systematic Review and Meta-Analysis

Panda

Mishra

Govind

et al. 2022

JCM

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This systematic review aimed to evaluate interventions individually and compare the clinical outcome of young, immature teeth treated with regenerative endodontic therapy (RET) and apexification procedure. The protocol was registered with PROSPERO (International Prospective Register of Systematic Reviews), bearing the registration number CRD42021230284. A bibliographic search in the biomedical databases was conducted in four databases—PubMed, CENTRAL, EMBASE and ProQuest—using searching keywords and was limited to studies published between January 2000 and April 2022 in English. The search was supplemented by manual searching, citation screening and scanning of all reference lists of selected paper. The study selection criteria were randomized clinical trial, prospective clinical studies and observational studies. The search found 32 eligible articles, which were included in the study. The quality assessment of the studies was performed using the Cochrane risk of bias tool for randomized control trials and non-randomized clinical studies. The meta-analysis was performed using Review Manager software (REVMAN, version 5). The results indicated that a clinicians’ MTA apexification procedure was more successful compared to calcium hydroxide. In RET, apical closure and overall success rate is statistically same for both apical platelet concentrates (APCs) and blood clots (BC). Both interventions have similar survival rates; however, RET should be preferred in cases where the root development is severely deficient, there is insufficient dentine and the tooth’s prognosis is hopeless even with an apexification procedure.

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Regenerative Endodontic Procedure of Immature Permanent Teeth with Leukocyte and Platelet-rich Fibrin: A Multicenter Controlled Clinical Trial

Cited by 26 publications

References 70 publications

Evaluation of the Effectiveness of Laser-Assisted Bleaching of the Teeth Discolored due to Regenerative Endodontic Treatment

Evaluation of the Effectiveness of Laser-Assisted Bleaching of the Teeth Discolored due to Regenerative Endodontic Treatment

Biomaterial scaffolds for clinical procedures in endodontic regeneration

Clinical Outcome and Comparison of Regenerative and Apexification Intervention in Young Immature Necrotic Teeth—A Systematic Review and Meta-Analysis

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