Regenerative endodontics—Creating new horizons

Dhillon, Harnoor; Kaushik, Mamta; Sharma, Rahul Swarup

doi:10.1002/jbm.b.33587

Cited by 25 publications

(25 citation statements)

References 118 publications

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“…Histologically, the pulp-dentin complex is composed of odontoblasts that synthesize dentin, numerous fibroblasts, undifferentiated mesenchymal cells, an extracellular matrix rich in Type I and II collagen arranged randomly, an amorphous substance composed of glycoproteins and proteoglycans, and numerous blood vessels and nerve fibres that enter through the root apex (Dhillon et al, 2016).…”

Section: Introductionmentioning

confidence: 99%

Induction of Root Development and Apical Closure in Permanent Mandibular Molar with Irreversible Pulpitis through Total Pulpotomy with Application of Mineral Trioxide Aggregate

Gómez

Fuentes

Saravia

et al. 2020

Int. J. Odontostomat.

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Loss of teeth vitality when root formation is incomplete, results in weaker structures leaving them prone to fractures and unfavourable long-term prognosis. Apexogenesis is currently the treatment of choice in immature teeth and is indicated in vital teeth without pulpal pathologies. The treatment aims to eliminate the causal agent of the damage, and provide the necessary conditions to preserve vitality in the tooth and induce apical root closure. A 6-year-old male patient was treated at the Endodontics Clinic, Universidad de La Frontera upon complaining of acute pain in tooth 30. The tooth presented incomplete root development due to dental caries with pulp exposure and a diagnosis of irreversible symptomatic pulpitis. Total pulpotomy was performed with the application of Mineral Trioxide Aggregate and controlled at 1, 4, 6, 7 and 12 months, achieving root development and apical closure in the permanent molar. The result was comparable with studies that support this therapy in teeth with irreversible pulpitis. This work seeks to contribute to the existing evidence on the management of immature permanent teeth with irreversible pulpitis to induce root development and apical closure, and maintain pulp vitality.

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Section: Introductionmentioning

confidence: 99%

Induction of Root Development and Apical Closure in Permanent Mandibular Molar with Irreversible Pulpitis through Total Pulpotomy with Application of Mineral Trioxide Aggregate

Gómez

Fuentes

Saravia

et al. 2020

Int. J. Odontostomat.

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“…Coronal pulpotomies have good success rates in permanent posterior teeth with closed apices in adults . Similarly, convectional pulpectomies, apexification, and regenerative techniques have all been shown to be successful techniques in adults . However, there appears to be limited evidence for the use of these techniques specifically for cFPM in children.…”

Section: Introductionmentioning

confidence: 99%

Success of endodontic management of compromised first permanent molars in children: A systematic review

Vernazza

Abdulmohsen

2019

Int J Paed Dentistry

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Background: Endodontic therapies may be required in the management of compromised first permanent molar teeth; their success in children, however, is unknown. Aim: To determine the success of endodontic therapies used on first permanent molar teeth in children aged sixteen and under. Design: MEDLINE, Embase, Cochrane library, CENTRAL, Clinicaltrials.gov, and the ISRCTN registry as well as relevant paediatric, endodontic, and traumatology journal were searched using a detailed search strategy. References of included studies were handsearched. A PICOS question was formulated: (P): children aged sixteen and under; (I): endodontic therapies (not pulp capping) on a first permanent molar tooth; (C): no treatment; (O): clinical success of endodontic therapy; and (S): all study types included.Bias was assessed using the Cochrane and Robins-I risk tools. Quality of evidence was assessed using the GRADE approach. Significant heterogeneity precluded meta-analysis. Results: 4172 studies were retrieved and eleven were included in the narrative review. Partial and coronal pulpotomies have high success rates in the short term and long term. Limited evidence is available for conventional pulpectomy or regenerative techniques. Conclusions: Partial and coronal pulpotomies are successful endodontic therapies for use in a compromised child's first permanent molar. K E Y W O R D Sendodontics, pulp biology, restorative dentistry/dental materials

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“…There is an increasing clinical need to develop predictable and effective therapeutic strategies to regenerate dental tissues and restore their morphology and functions 1, 2. Thus, dental tissue engineering is an attractive therapeutic strategy that complements traditional restorative techniques and benefits from recent advances in stem cell biology, molecular biology, genomics, and proteomics 3 .…”

Section: Introductionmentioning

confidence: 99%

Wnt and BMP signaling crosstalk in regulating dental stem cells: Implications in dental tissue engineering

et al. 2016

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Tooth is a complex hard tissue organ and consists of multiple cell types that are regulated by important signaling pathways such as Wnt and BMP signaling. Serious injuries and/or loss of tooth or periodontal tissues may significantly impact aesthetic appearance, essential oral functions and the quality of life. Regenerative dentistry holds great promise in treating oral/dental disorders. The past decade has witnessed a rapid expansion of our understanding of the biological features of dental stem cells, along with the signaling mechanisms governing stem cell self-renewal and differentiation. In this review, we first summarize the biological characteristics of seven types of dental stem cells, including dental pulp stem cells, stem cells from apical papilla, stem cells from human exfoliated deciduous teeth, dental follicle precursor cells, periodontal ligament stem cells, alveolar bone-derived mesenchymal stem cells (MSCs), and MSCs from gingiva. We then focus on how these stem cells are regulated by bone morphogenetic protein (BMP) and/or Wnt signaling by examining the interplays between these pathways. Lastly, we analyze the current status of dental tissue engineering strategies that utilize oral/dental stem cells by harnessing the interplays between BMP and Wnt pathways. We also highlight the challenges that must be addressed before the dental stem cells may reach any clinical applications. Thus, we can expect to witness significant progresses to be made in regenerative dentistry in the coming decade.

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Regenerative endodontics—Creating new horizons

Cited by 25 publications

References 118 publications

Induction of Root Development and Apical Closure in Permanent Mandibular Molar with Irreversible Pulpitis through Total Pulpotomy with Application of Mineral Trioxide Aggregate

Induction of Root Development and Apical Closure in Permanent Mandibular Molar with Irreversible Pulpitis through Total Pulpotomy with Application of Mineral Trioxide Aggregate

Success of endodontic management of compromised first permanent molars in children: A systematic review

Wnt and BMP signaling crosstalk in regulating dental stem cells: Implications in dental tissue engineering

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