Regenerative Endodontics for Adult Patients

He, Ling; Kim, Sahng G.; Gong, Qimei; Zhong, Juan; Wang, Sainan; Zhou, Xuedong; Ye, Ling; Ling, Junqi; Mao, Jeremy J.

doi:10.1016/j.joen.2017.06.012

Cited by 64 publications

(59 citation statements)

References 45 publications

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“…It is plausible that locally populated MSCs from periapical region, including PDLSCs, SCAP, and alveolar BMSCs account for recruitment. 79,80 In addition, systematically circulated stem/progenitor cells appear clinically available. 75 However, regarding the regenerated pulp-dentin anatomically mimicking native tissue, periapical stem cells appear less therapeutically applicable and feasible as compared with PSCs.…”

Section: Cell Transplantation-based Regenerative Endodonticsmentioning

confidence: 99%

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Pulp stem cells derived from human permanent and deciduous teeth: Biological characteristics and therapeutic applications

Shi

Mao

Liu

2020

Stem Cells Translational Medicine

161

128

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Human pulp stem cells (PSCs) include dental pulp stem cells (DPSCs) isolated from dental pulp tissues of human extracted permanent teeth and stem cells from human exfoliated deciduous teeth (SHED). Depending on their multipotency and sensitivity to local paracrine activity, DPSCs and SHED exert therapeutic applications at multiple levels beyond the scope of the stomatognathic system. This review is specifically concentrated on PSC‐updated biological characteristics and their promising therapeutic applications in (pre)clinical practice. Biologically, distinguished from conventional mesenchymal stem cell markers in vitro, NG2, Gli1, and Celsr1 have been evidenced as PSC markers in vivo. Both perivascular cells and glial cells account for PSC origin. Therapeutically, endodontic regeneration is where PSCs hold the most promises, attributable of PSCs' robust angiogenic, neurogenic, and odontogenic capabilities. More recently, the interplay between cell homing and liberated growth factors from dentin matrix has endowed a novel approach for pulp‐dentin complex regeneration. In addition, PSC transplantation for extraoral tissue repair and regeneration has achieved immense progress, following their multipotential differentiation and paracrine mechanism. Accordingly, PSC banking is undergoing extensively with the intent of advancing tissue engineering, disease remodeling, and (pre)clinical treatments.

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Section: Cell Transplantation-based Regenerative Endodonticsmentioning

confidence: 99%

“…In cases of advanced pulpitis or necrosis, pulp is then extirpated completely. It is plausible that locally populated MSCs from periapical region, including PDLSCs, SCAP, and alveolar BMSCs account for recruitment . In addition, systematically circulated stem/progenitor cells appear clinically available .…”

Section: Introductionmentioning

confidence: 99%

Pulp stem cells derived from human permanent and deciduous teeth: Biological characteristics and therapeutic applications

Shi

Mao

Liu

2020

Stem Cells Translational Medicine

161

128

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“…In dental pulp and dentin regeneration, stem/progenitor cells differentiate into odontoblasts, pulp fibroblasts, and other niche cells. 27 Cell homing shows a potential for dental pulp regeneration in mature permanent teeth in adults, as shown by He et al 28 The development of biologically-based approaches to regenerate or repair dental pulp has become possible because of recent advances in tissue engineering and biomaterials. However, the several severe problems associated with this approach may render it not feasible for a clinical setting, at least in the near future.…”

Section: Disinfection Vs Regenerationmentioning

confidence: 96%

Current and future perspectives for dentin-pulp tissue engineering - an update

Srivastava¹

2019

S. Afr. dent. j.

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“…Currently, the most reliable option for the treatment of necrotic mature teeth is still root canal treatment. However, endodontically treated teeth are susceptible to reinfection and fracture, and the failure rate is close to 25% at 3-5 years (8). Moreover, endodontically treated teeth will remain devitalized throughout the patient's lifetime and therefore defenseless to new caries lesions, as the absence of pulp implies the lack of tooth defense mechanisms (9,10).…”

mentioning

confidence: 99%

“…Moreover, endodontically treated teeth will remain devitalized throughout the patient's lifetime and therefore defenseless to new caries lesions, as the absence of pulp implies the lack of tooth defense mechanisms (9,10). Therefore, teeth revitalization offers several advantages over conventional root canal treatment, such as the recovery of the natural immune system and a structurally more resistant tooth (8,11,12).…”

mentioning

confidence: 99%

A Regenerative Endodontic Approach in Mature Ferret Teeth Using Rodent Preameloblast-conditioned Medium

Bucchi

Gimeno-Sandig

Valdivia-Gandur

et al. 2019

In Vivo

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Background: This study evaluated the effectiveness of a regenerative endodontic approach to regenerate the pulp tissue in mature teeth of ferret. The presence of odontoblastlike cells in the newly-formed tissue of teeth treated with or without preameloblast-conditioned medium was evaluated based on morphological criteria. Materials and Methods: Twenty-four canines from six ferrets were treated. The pulp was removed, and the apical foramen was enlarged. After inducing the formation of a blood clot, a collagen sponge with or without preameloblast-conditioned medium was placed underneath the cementoenamel junction. The samples were analyzed at the eighth week of follow-up. Results: Vascularized connective tissue was observed in 50% of teeth, without differences between groups. The tissue occupied the apical third of the root canals. Odontoblast-like cells were not observed in any group. Conclusion: Revitalization of mature teeth is possible, at least in the apical third of the root canal. Further experimental research is needed to produce more reliable outcomes.

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Regenerative Endodontics for Adult Patients

Cited by 64 publications

References 45 publications

Pulp stem cells derived from human permanent and deciduous teeth: Biological characteristics and therapeutic applications

Pulp stem cells derived from human permanent and deciduous teeth: Biological characteristics and therapeutic applications

Current and future perspectives for dentin-pulp tissue engineering - an update

A Regenerative Endodontic Approach in Mature Ferret Teeth Using Rodent Preameloblast-conditioned Medium

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