Regenerative hyperplasia of the cirrhotic liver following partial hepatectomy

Islami, Abdol H.; Pack, George T.; Hubbard, John Castleman

doi:10.1002/1097-0142(195807/08)11:4<663::aid-cncr2820110402>3.0.co;2-s

Cited by 41 publications

(10 citation statements)

References 8 publications

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“…Mann et al34 found that liver regeneration occurred in livers that manifested mild to moderate cirrhosis, but not in severely cirrhotic livers. In contrast, Islami et al33 reported that almost complete regeneration occurred in severely cirrhotic livers. More recently, Ogawa et al35 reported on the almost complete recovery of liver weight after a hepatectomy in rats with CCl 4 ‐induced cirrhosis.…”

Section: Discussionmentioning

confidence: 92%

“…PVL‐induced hypertrophy has also been developed in experimentally induced liver cirrhosis in the rat28 and the dog 31. Previous studies have investigated the regeneration of cirrhotic livers in hepatectomized animal models . Mann et al34 found that liver regeneration occurred in livers that manifested mild to moderate cirrhosis, but not in severely cirrhotic livers.…”

Section: Discussionmentioning

confidence: 99%

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Morphological and functional changes after portal vein occlusion in rats

Tanaka

Ikeda

Matsuyama

et al. 1997

J Hep Bil Pancr Surg

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We studied the morphological and functional changes after ligation or embolization of a portal vein branch that perfused the median and the left lateral lobes of the liver in rats. After surgery, regenerative hypertrophy in the non-occluded liver lobes and atrophy in the occluded liver lobes were seen. In the non-occluded liver lobes, mitosis of the hepatocytes was seen most frequently on postoperative day 2. The density of the Kupffer cells after postoperative day 2 was about twice that in intact rats. In the occluded liver lobe, apoptosis of the hepatocytes was seen most frequently on the postoperative day 4, but the density and the phagocytic activity of Kupffer cell were reduced. There was no significant difference in hepatic parenchymal function such as K1CG and the blood levels of antithrombin III between rats on postoperative day 7 and intact rats. On the other hand, liver regeneration was presented even in rats with cirrhosis.However, the DNA synthesis and ODC activity in cirrhotic rats were lower than those in normal rats. Workshop w1The evaluation of postoperative early complications and long-term nutrition after pancreatoduodenectomy Y. Nakamoto, T.K ajiwara,H. Meguro,T. Tani, Y. Konisi, K. Yanagihasi ,T.Hashimoto,S .Fujiie Dept. of Surgery, Kobe city general hospital 155 pancreatoduodenectomy(PD) was investigated in our situation from 1981 Aug. to 1995 Dec.. PD-II : 58 cases, PD-Ill : 50 cases, PpPD-III : 42 cases, others : 5 cases. We evaluated early complications and long-term nutrition after the surgery. Among these three procedures there was no significant difference in leakage and heavy complications ( acute renal failure, MOF, DIC). The ratio of postoperative intraperitoneal bleeding was significantly less after PpPD-III than after others. The incidence of peptic ulcer was 1 case in each procedure. The incidence of fatty liver was 3 cases in PD-II, 5 cases in PpPD-III. In 6months weight gain was better after PpPD-III, but there was no statistically significant differences. In 12 months, weight gain was significantly greater after PpPD-1II. In 6, 12 months gains of serum albumin, it was better after PpPD-lll,but there was no statistically significant differences. In PD-III, PpPD-1II the passage of food is physical, and in PpPD-III postoperative long term nutrition is superior. We recommend this procedure. W2Function of the remnant pancreas after pancreatoduodenectomy (PD) -short term and long term-H.Taoka, TJ-Iigasiguchi, H.Yokoi, Y.Ogura, T.Noguchi, and Y. Kawarada 1st Dept. of Surg., Mie Univ., Mie, JapanThe purpose of this study was to assess the pathophysiology of the remnant pancreas after PD, and PpPD or DpPHR (pPD below) . The subjects of this study were 67 cases who underwent PD and 12 cases who underwent pPD during the past 10years. Patients with diseases in which the main lesion was in the pancreatic parenchyma (e.g., pancreatic carcinoma and chronic pancreatitis) were classified in group A and patients with in which the main lesion was outside the pancreatic parenchyma ( e.g., carcinom...

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Section: Discussionmentioning

confidence: 92%

Section: Discussionmentioning

confidence: 99%

Morphological and functional changes after portal vein occlusion in rats

Tanaka

Ikeda

Matsuyama

et al. 1997

J Hep Bil Pancr Surg

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“…It is an issue of controversy whether a cirrhotic liver will regenerate after partial hepatectomy and, if so, whether the rate of regeneration is similar to that of a noncirrhotic liver. Previous studies in rats using a CC1, model of cirrhosis found that liver regeneration is normal in cirrhotic rats compared with that in noncirrhotic controls (1,2). Other investigators have been unable to confirm these findings in the rat or in other experimental animals (3, 4).…”

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confidence: 95%

Liver Regeneration and the Effect of Exogenous Putrescine on Regenerative Activity After Partial Hepatectomy in Cirrhotic Rats

et al. 1992

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There are conflicting data regarding the ability of the liver to regenerate after partial hepatectomy in animals and humans with cirrhosis. The purpose of this study was to document liver regeneration after partial hepatectomy in a carbon tetrachloride rat model of cirrhosis and to determine whether exogenous putrescine, a polyamine that has been reported to stimulate liver regeneration in animal models of acute liver failure, enhances regenerative activity in cirrhosis. Liver fibrosis and cirrhosis were produced by weekly intragastric gavage with carbon tetrachloride in 130 adult male rats. Vehicle-gavaged rats (n = 12) served as healthy controls. At surgery and at 4 and 8 hr after 70% hepatectomy, rats received normal saline solution or 1 or 10 mg/kg putrescine by intraperitoneal injection. Another group (n = 32) of carbon tetrachloride-treated rats was given putrescine (100 mg/kg) or normal saline solution twice daily for 10 days before partial hepatectomy and at 0, 4 and 8 hr after partial hepatectomy. Liver regeneration was documented 24 and 48 hr after partial hepatectomy on the basis of restitution of liver mass, ornithine decarboxylase activity and [3H]thymidine incorporation into liver DNA. Automated image analysis of the resected liver specimens separated carbon tetrachloride-treated rats into two subgroups: those with bridging fibrosis (fibrotic group) and those with micronodular cirrhosis (cirrhotic group). Restitution of liver mass and ornithine decarboxylase activity at 24 and 48 hr after partial hepatectomy were similar to carbon tetrachloride-treated rats (both fibrotic and cirrhotic) and vehicle-treated healthy controls.(ABSTRACT TRUNCATED AT 250 WORDS)

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“…Liver regeneration is an essential process for recovery from liver injury. Rats with advanced stages of CCl 4-produced cirrhosis recovered completely after 70% partial hepatectomy, which is known to produce a major stimulus for repair (18). Post-operative therapy with a known drug metabolism inducer, PB, also accelerates liver regeneration following partial hepatectomy (7,17,24,38,46).…”

Section: Discussionmentioning

confidence: 99%

Reversibility of Rat Liver Cirrhosis by Medroxyprogesterone Acetate

et al. 1989

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ABSTRAcrTh~possible effe:ts of a synthetic progesterone, medroxyprogesterone acetate (MPA), on carbon tetrachloride/phenobarbital (CCI.;PB)-induced rat liver injury were studied by morphological methods. CCI.; PB-.t~eated rats showed extensive liver fibrosis consisting of procollagen type III aminoterminal propeptideposI~lve strands and fibres with concomitant extensive basement membrane deposits and fibronectin synhesls. MP.A treatment after CCl/PB-induced liver damage reduced alterations in cytoplasmic organelles, inflammation .an~hemorrhages and reversed the fibrosis, mostly around individual liver cells, possibly due to the normalization of cellular structure and function with a decrease in fibronectin deposits.

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Regenerative hyperplasia of the cirrhotic liver following partial hepatectomy

Cited by 41 publications

References 8 publications

Morphological and functional changes after portal vein occlusion in rats

Morphological and functional changes after portal vein occlusion in rats

Liver Regeneration and the Effect of Exogenous Putrescine on Regenerative Activity After Partial Hepatectomy in Cirrhotic Rats

Reversibility of Rat Liver Cirrhosis by Medroxyprogesterone Acetate

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