Regenerative Therapy and Cancer: <i>In Vitro</i> and <i>In Vivo</i> Studies of the Interaction Between Adipose-Derived Stem Cells and Breast Cancer Cells from Clinical Isolates

Zimmerlin, Ludovic; Donnenberg, Albert D.; Rubin, J. Peter; Basse, Per H.; Landreneau, Rodney J.; Donnenberg, Vera S.

doi:10.1089/ten.tea.2010.0248

Cited by 213 publications

(160 citation statements)

References 35 publications

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“…The adipose-derived cell's immunomodulatory and immunosuppressive properties present additional concerns. Recent reports document the ability of ASCs to promote the proliferation of active breast cancer cells in vitro and in vivo via paracrine mechanisms [38][39][40][41][42]. Comparable studies indicate that ASCs promote the growth of prostate cancer cell lines transplanted into immunodeficient mice [43].…”

Section: Tumorigenesismentioning

confidence: 99%

Concise Review: Adipose-Derived Stromal Vascular Fraction Cells and Stem Cells: Let's Not Get Lost in Translation

et al. 2011

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Subcutaneous fat has emerged as an alternative tissue source for stromal/stem cells in regenerative medicine. Over the past decade, international research efforts have established a wealth of basic science and preclinical evidence regarding the differentiation potential and regenerative properties of both freshly processed, heterogeneous stromal vascular fraction cells and culture expanded, relatively homogeneous adipose-derived stromal/stem cells. The stage has been set for clinicians to translate adipose-derived cells from the bench to the bedside; however, this process will involve “development” steps that fall outside of traditional “hypothesis-driven, mechanism-based” paradigm. This concise review examines the next stages of the development process for therapeutic applications of adipose-derived cells and highlights the current state of the art regarding clinical trials. It is recommended that the experiments addressing these issues be reported comprehensively in the peer-review literature. This transparency will accelerate the standardization and reproducibility of adipose-derived cell therapies with respect to their efficacy and safety.

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Section: Tumorigenesismentioning

confidence: 99%

Concise Review: Adipose-Derived Stromal Vascular Fraction Cells and Stem Cells: Let's Not Get Lost in Translation

et al. 2011

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“…133 Although acute toxicity seems not to be a major concern, based on findings in >2,000 patients so far exposed to MSCs, 134 and fewer to ADSCs, 135 evidence from animal models suggests that the approach might be associated with loss of endogenous tumor surveillance. In fact, descriptions of the possible involvement of ADSCs in tumorigenesis have been reported in vitro e in vivo, [135][136][137] and biological mechanisms are poorly understood. ADSCs are appealing thanks to their ability to proliferate and differentiate also secreting cytokines and growth factors and their immunoregulatory function.…”

Section: Limitationsmentioning

confidence: 99%

Mesenchymal stem cells: potential for therapy and treatment of chronic non-healing skin wounds

et al. 2015

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(2015) Mesenchymal stem cells: potential for therapy and treatment of chronic non-healing skin wounds, Organogenesis, 11:4, 183-206, DOI: 10.1080/15476278.2015 ABSTRACT. Wound healing is a complex physiological process including overlapping phases (hemostatic/inflammatory, proliferating and remodeling phases). Every alteration in this mechanism might lead to pathological conditions of different medical relevance. Treatments for chronic nonhealing wounds are expensive because reiterative treatments are needed. Regenerative medicine and in particular mesenchymal stem cells approach is emerging as new potential clinical application in wound healing. In the past decades, advance in the understanding of molecular mechanisms underlying wound healing process has led to extensive topical administration of growth factors as part of wound care. Currently, no definitive treatment is available and the research on optimal wound care depends upon the efficacy and cost-benefit of emerging therapies.Here we provide an overview on the novel approaches through stem cell therapy to improve cutaneous wound healing, with a focus on diabetic wounds and Systemic Sclerosis-associated ulcers, which are particularly challenging. Current and future treatment approaches are discussed with an emphasis on recent advances.

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“…Moreover, MSC could undergo transformation into malignant cells and tumor formation in vivo (Muehlberg et al, 2009, Karnoub et al, 2007. Others suggest that MSC should not affect the status of dormant cancer cells (Zimmerlin et al, 2011). The possibility of tumor growth and metastasis induced by MSC has an effect on the safety of their use for clinical applications.…”

Section: Processing Of Lipoaspirate Samples For Optimal Mesenchymal Smentioning

confidence: 99%

Processing of Lipoaspirate Samples for Optimal Mesenchymal Stem Cells Isolation

Baptista¹,

Silva²,

Pedrosa³

et al. 2011

Advanced Techniques in Liposuction and Fat Transfer

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Regenerative Therapy and Cancer: In Vitro and In Vivo Studies of the Interaction Between Adipose-Derived Stem Cells and Breast Cancer Cells from Clinical Isolates

Cited by 213 publications

References 35 publications

Concise Review: Adipose-Derived Stromal Vascular Fraction Cells and Stem Cells: Let's Not Get Lost in Translation

Concise Review: Adipose-Derived Stromal Vascular Fraction Cells and Stem Cells: Let's Not Get Lost in Translation

Mesenchymal stem cells: potential for therapy and treatment of chronic non-healing skin wounds

Processing of Lipoaspirate Samples for Optimal Mesenchymal Stem Cells Isolation

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