Regional amyloid distribution and impact on mortality in light-chain amyloidosis: a T1 mapping cardiac magnetic resonance study

Wan, Ke; Li, Weihao; Sun, Jiayu; Xu, Yuanwei; Wang, Jie; Liu, Hong; Yang, Dong; Cheng, Wei; Zhang, Qing; Zeng, Zhi; Zhou, Xiaoyue; Han, Yuchi; Chen, Yucheng

doi:10.1080/13506129.2019.1578742

Cited by 27 publications

(26 citation statements)

References 21 publications

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“… ECV extracellular volume fraction, FS field strength, T Tesla, n number of study subjects included in the weighted mean values, mean p pooled weighted mean, SD p pooled standard deviation, LL lower limit, UL upper limit, MOLLI modified look locker inversion-recovery, ShMOLLI short MOLLI, Siemens Siemens Medical Solutions, Erlangen, Germany, Philips Philips Healthcare, Best, The Netherlands a Pooled weighted values from references [ 118 , 121 , 129 , 132 , 136 , 141 , 142 ] b Pooled weighted values from references [ 116 , 122 – 124 , 128 , 130 , 131 , 135 , 142 , 147 , 148 ] c Pooled weighted values from references [ 127 , 139 , 145 , 146 ] d Pooled weighted values from references [ 125 , 133 , 136 , 144 , 149 ] e Pooled weighted values from references [ 137 , 138 ] f Pooled weighted values from references [ 126 , 134 , 140 , 145 ] g Pooled weighted values from references [ 121 , 129 , 142 ] h Pooled weighted values from references [ 124 , 128 , 130 , 131 , 142 ] i Values from reference [ 127 ] j Pooled weighted values from references [ 143 , 144 …”

Section: Normal Values Of Myocardial T1 Relaxation Time and The Extramentioning

confidence: 99%

Reference ranges (“normal values”) for cardiovascular magnetic resonance (CMR) in adults and children: 2020 update

Kawel‐Boehm

Hetzel

Ambale-Venkatesh

et al. 2020

Journal of Cardiovascular Magnetic Resonance

351

243

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Cardiovascular magnetic resonance (CMR) enables assessment and quantification of morphological and functional parameters of the heart, including chamber size and function, diameters of the aorta and pulmonary arteries, flow and myocardial relaxation times. Knowledge of reference ranges (“normal values”) for quantitative CMR is crucial to interpretation of results and to distinguish normal from disease. Compared to the previous version of this review published in 2015, we present updated and expanded reference values for morphological and functional CMR parameters of the cardiovascular system based on the peer-reviewed literature and current CMR techniques. Further, databases and references for deep learning methods are included.

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Section: Normal Values Of Myocardial T1 Relaxation Time and The Extramentioning

confidence: 99%

Reference ranges (“normal values”) for cardiovascular magnetic resonance (CMR) in adults and children: 2020 update

Kawel‐Boehm

Hetzel

Ambale-Venkatesh

et al. 2020

Journal of Cardiovascular Magnetic Resonance

351

243

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“…Figure 1 illustrates the PRISMA flow diagram for the literature search and disposition of studies. After removing duplicates, 230 abstracts were reviewed and 41 full‐text articles were assessed, yielding 22 eligible studies for analyses—including six diagnostic, 15–20 17 reference range, 4,15,19–33 and six prognostic 4,18,20,33–35 studies. Study and clinical characteristics of these studies, published between 2007 and 2020, are shown in Table 1.There was a total of 4386 patients in these studies, of which 2089 had CA.…”

Section: Resultsmentioning

confidence: 99%

Reference Ranges, Diagnostic and Prognostic Utility of Native T1 Mapping and Extracellular Volume for Cardiac Amyloidosis: A Meta‐Analysis

Wang

Brizneda

Kwon

et al. 2020

Magnetic Resonance Imaging

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Background Cardiac MRI is central to the evaluation of cardiac amyloidosis (CA). Native T1 mapping and extracellular volume (ECV) are novel MR techniques with evolving utility in cardiovascular diseases, including CA. Purpose To perform a meta‐analysis of the diagnostic and prognostic data of native T1 mapping and ECV techniques for assessing CA. Study Type Systematic review and meta‐analysis. Population In all, 3520 patients including 1539 with CA from 22 studies retrieved following systematic search of Pubmed, Cochrane, and Embase. Field Strength/Sequence 1.5T or 3.0T/modified Look–Locker inversion recovery (MOLLI) or shortened MOLLI (shMOLLI) sequences. Assessment Meta‐analysis was performed for all CA and for light‐chain (AL) and transthyretin (ATTR) subtypes. Thresholds were calculated to classify native T1 and ECV values as not suggestive, indeterminate, or suggestive of CA. Statistical Analysis Area under the receiver‐operating characteristic curves (AUCs) and hazards ratios (HRs) with 95% confidence intervals (95% CI) were pooled using random‐effects models and Open‐Meta(Analyst) software. Results Six studies were diagnostic, 16 studies reported T1 and ECV values to determine reference range, and six were prognostic. Pooled AUCs (95% CI) for diagnosing CA were 0.92 (0.89–0.96) for native T1 mapping and 0.96 (0.93–1.00) for ECV, with similarly high detection rates for AL‐ and ATTR‐CA. Based on the pooled values of native T1 and ECV in CA and control subjects, the thresholds that suggested the absence, indeterminate, or presence of CA were identified as <994 msec, 994–1073 msec, and >1073 msec, respectively, for native T1 at 1.5T. Pooled HRs (95% CI) for predicting all‐cause mortality were 1.15 (1.08–1.22) for native T1 mapping as a continuous parameter, 1.19 (1.01–1.40) for ECV as a continuous parameter, and 4.93 (2.64–9.20) for ECV as a binary threshold. Data Conclusion Native T1 mapping and ECV had high diagnostic performance and predicted all‐cause mortality in CA. Level of Evidence 1 Technical Efficacy Stage 2

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“…Patients with diffuse fibrosis may be at risk for the development of cardiomyopathy over time. An elevated ECV is associated with increased mortality independent of the presence of LGE in conditions such as heart failure, myocardial infarction, amyloidosis, and adults with repaired tetralogy of Fallot [52] , [53] , [54] , [55] , [56] , [57] , [58] , [59] , [60] , [61] , [62] , [63] . An elevated ECV has also been associated with adverse clinical outcomes in adults with aortic stenosis including decreased exercise performance and increased mortality following aortic valve replacement surgery [18] , [19] .…”

Section: Discussionmentioning

confidence: 99%

Myocardial fibrosis in patients with a history of Kawasaki disease

Dusenbery

Colan

Baker

et al. 2021

IJC Heart & Vasculature

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Regional amyloid distribution and impact on mortality in light-chain amyloidosis: a T1 mapping cardiac magnetic resonance study

Cited by 27 publications

References 21 publications

Reference ranges (“normal values”) for cardiovascular magnetic resonance (CMR) in adults and children: 2020 update

Reference ranges (“normal values”) for cardiovascular magnetic resonance (CMR) in adults and children: 2020 update

Reference Ranges, Diagnostic and Prognostic Utility of Native T1 Mapping and Extracellular Volume for Cardiac Amyloidosis: A Meta‐Analysis

Myocardial fibrosis in patients with a history of Kawasaki disease

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