Regional and transient ischemia/reperfusion injury in the liver improves therapeutic efficacy of allogeneic intraportal hepatocyte transplantation in low-density lipoprotein receptor deficient Watanabe rabbits

Attaran, Masoumeh; Schneider, Andrea; Grote, Christiane; Zwiens, Caroline; Flemming, Peer; Gratz, K. F.; Jochheim, Andrea; Bahr, Matthias J.; Manns, Michael P.; Ott, Michael

doi:10.1016/j.jhep.2004.07.014

Cited by 27 publications

(21 citation statements)

References 47 publications

(51 reference statements)

Supporting

Mentioning

Contrasting

Unclassified

Order By: Relevance

“…Many strategies have been employed to improve the proliferation of transplanted cells within the recipient liver. Preconditioning with irradiation and ischaemia reperfusion injury (IRI) markedly improved the repopulation of dipeptidyl peptidase IV (DPPIV)-negative livers by syngeneic F344 wild-type hepatocytes [34]; likewise, transient IRI performed on LDL receptor-deficient Watanabe rabbits improved the therapeutic benefit (ie lowering of LDL cholesterol) of multiple intraportal infusions of allogeneic hepatocytes [35]. In the retrorsine pretreated and partially hepatectomized DPPIV-deficient rat, superior repopulation by wild-type hepatocytes was achieved by selecting donor cells with low rather than high asialoglycoprotein receptor expression [36].…”

Section: Cell Therapies Using Hepatocytesmentioning

confidence: 99%

Stem cells in liver regeneration, fibrosis and cancer: the good, the bad and the ugly

Alison

Islam

Lim

2008

The Journal of Pathology

201

149

View full text Add to dashboard Cite

The worldwide shortage of donor livers to transplant end stage liver disease patients has prompted the search for alternative cell therapies for intractable liver diseases, such as acute liver failure, cirrhosis and hepatocellular carcinoma (HCC). Under normal circumstances the liver undergoes a low rate of hepatocyte 'wear and tear' renewal, but can mount a brisk regenerative response to the acute loss of two-thirds or more of the parenchymal mass. A body of evidence favours placement of a stem cell niche in the periportal regions, although the identity of such stem cells in rodents and man is far from clear. In animal models of liver disease, adopting strategies to provide a selective advantage for transplanted hepatocytes has proved highly effective in repopulating recipient livers, but the poor success of today's hepatocyte transplants can be attributed to the lack of a clinically applicable procedure to force a similar repopulation of the human liver. The activation of bipotential hepatic progenitor cells (HPCs) is clearly vital for survival in many cases of acute liver failure, and the signals that promote such reactions are being elucidated. Bone marrow cells (BMCs) make, at best, a trivial contribution to hepatocyte replacement after damage, but other BMCs contribute to the hepatic collagen-producing cell population, resulting in fibrotic disease; paradoxically, BMC transplantation may help alleviate established fibrotic disease. HCC may have its origins in either hepatocytes or HPCs, and HCCs, like other solid tumours appear to be sustained by a minority population of cancer stem cells.

show abstract

Section: Cell Therapies Using Hepatocytesmentioning

confidence: 99%

Stem cells in liver regeneration, fibrosis and cancer: the good, the bad and the ugly

Alison

Islam

Lim

2008

The Journal of Pathology

201

149

View full text Add to dashboard Cite

show abstract

“…In low-density lipoprotein receptor deficient Watanabe rabbits, transient ischaemia reperfusion injury of the recipient liver has been shown to improve the therapeutic efficacy of allogeneic intraportal hepatocyte transplantation [5]. This technique may offer a perspective to improve the engraftment of transplanted hepatocytes in patients with metabolic liver disease.…”

Section: Route Of Administrationmentioning

confidence: 99%

Present status and perspectives of cell-based therapies for liver diseases

Nüssler

König

Ott

et al. 2006

Journal of Hepatology

Self Cite

177

129

View full text Add to dashboard Cite

“…The inherent risks of the procedure may be significantly reduced by restriction to single liver lobes. Cell transplantation combined with regional ischemia/reperfusion of less than half of the liver mass partially corrected hypercholesterolemia even in the absence of radiation theraphy [12]. The radiation dosage required for inhibition of hepatocyte proliferation would not necessarily impair liver function, but would definitely cause DNA damage and carry the risk for tumour formation.…”

Section: See Article Pages 99-106mentioning

confidence: 99%