Regional blood flow in the normal cerebral hemisphere.

Wilkinson, Iain; Bull, J. W. D.; Duboulay, G; Marshall, John; Russell, Richard A.; Symon, Lindsay

doi:10.1136/jnnp.32.5.367

Cited by 139 publications

(42 citation statements)

References 7 publications

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“…As in the original PET images, the effects of physiological stimulation on the mean global CBF were present. Furthermore, the local variations of the rCBF within the cerebral cortex, with highest values in the prefrontal cortex (Wilkinson et al , 1969;Ris berg and Ingvar, 1973;Roland and Larsen, 1976), Table 1. were obvious. As with the averaging programme by Fox et a1.…”

Section: Quantitative Accuracy and Precisionmentioning

confidence: 99%

Accuracy and Precision of the Computerized Brain Atlas Programme for Localization and Quantification in Positron Emission Tomography

Seitz¹,

Bohm

Greitz³

et al. 1990

J Cereb Blood Flow Metab

111

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Summary:The computerized brain atlas programme (CBA) provides a powerful tool for the anatomical anal ysis of functional images obtained with positron emission tomography (PET). With a repertoire of simple transfor mations, the data base of the CBA is first adapted to the anatomy of the subject's brain represented as a set of magnetic resonance (MR) or computed tomography (CT) images. After this, it is possible to spatially standardize (reformat) any set of tomographic images related to the subject, PET images, as well as CT and MR images, by applying the inverse atlas transformations. From these reformatted images, statistical images, such as average images and associated error images corresponding to dif ferent groups of subjects, may be produced. In all these images, anatomical structures can be localized using the atlas data base and the functional values can be evaluated quantitatively. The purpose of this study was to deter mine the spatial and quantitative accuracy and precision of the calculated regional mean values. Therefore, the CBA was applied to regional CBF (rCBF) measurements with [ 11 C]fluoromethane and PET on 26 healthy male vol unteers during rest and during three different physiolog ical stimulation tasks. First, the spatial accuracy and pre cision of the reformation process were determined by measuring the spread of defined anatomical structures in the reformatted MR images of the subjects. Second, the mean global CBF and the mean rCBF in the average PET images were compared with the global CBF and rCBF in the original PET images. Our results demonstrate that the reformation process accurately transformed the individReceived July 24, 1989; revised November 24, 1989; accepted November 28, 1989. Address correspondence and reprint requests to Dr. R. J. Seitz at Department of Clinical Neurophysiology, Karolinska Hospital, Box 60500, S-10401 Stockholm, Sweden.Abbreviations used: CBA, computerized brain atlas pro gramme; CT, computed tomography; MR, magnetic resonance; PET, positron emission tomography; rCBF, regional CBF; rCMR, regional CMR; ROl, region of interest. For image types, see Table I. . O wing to this high sampling resolution, it was possible to differentiate the mean rCBF changes in adjacent activated fields such as the left motor hand area from the sensory hand area and the left premotor cortex. (c) By calculating the rela tion of the mean rCBF change to the SEM of the mean rCBF change on a pixel-by-pixel basis, areas with signif icant rCBF changes could be determined. By use of the CBA, it was found that there was a high intersubject con sistency in location of stimulation-induced rCBF changes. Furthermore, the rCBF changes in specifically stimulated areas were of similar magnitude among the subjects. It was shown that the stimulation-induced mean rCBF increases may be accompanied by mean rCBF de creases in other areas. Key Words: Computerized brain atlas-Magnetic resonance imaging-Physiological stim ulation-Positron emission tomography.Positron emission tomography (PET) is a no...

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Section: Quantitative Accuracy and Precisionmentioning

confidence: 99%

Accuracy and Precision of the Computerized Brain Atlas Programme for Localization and Quantification in Positron Emission Tomography

Seitz¹,

Bohm

Greitz³

et al. 1990

J Cereb Blood Flow Metab

111

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“…These are comparable to normal values for gray and white matter reported by other workers. 9 The coefficient of variation of local perfusion rates was 12% for compartment I and 15% for compartment II in this study. The coefficients of variation for the measurements (accuracy terms) were 5% and 7%, respectively.…”

Section: Correlation With Cerebral Arterlographymentioning

confidence: 85%

“…The program starts with initial parameter "guesses" corresponding to normal flow rates reported for man. 9 ' ls Convergence upon a final fit was rapid, requiring eight to ten iterations on an average. Fitting the data obtained from 100 crystals in one study required approximately three minutes of CPU time on an IBM 360/91.…”

Section: Data Processingmentioning

confidence: 99%

Measurement of Regional Cerebral Blood Flow With ¹³³ Xenon and a Multiple-Crystal Scintillation Camera

Sciacca

Brust

et al. 1974

Stroke

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Abstract• A method was devised to measure gray and white matter cerebral blood flow simultaneously in multiple regions of the brain using 1S3 Xenon and a multiple-crystal scintillation camera. Following magnification cerebral arteriography, 1S3Xe was injected into the internal carotid artery and the washout of tracer was monitored with a scintillation camera which consists of 294 individually collimated Nal (Tl) crystals. These data, obtained from each crystal overlying the brain, were processed by a weighted least-squares nonlinear regression technique. The blood flow rates of the rapid and slow compartments were calculated by the Kety-Schmidt formula along with 95% confidence limits for each measurement.In four patients, local increases or decreases in regional cerebral flow were correlated with areas of pathology. In one patient with a cerebral arteriovenous malformation, regions of local shunting of tracer were identified. Application of a three-compartment analysis to these curves permitted estimation of the magnitude of shunting along with gray and white matter flow in the lesion. The increased discrimination provided by the multiple-crystal camera and the estimates of measurement accuracy obtained by this mathematical analysis may facilitate more precise localization of regional blood flow abnormalities in intracranial disease.

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“…The clearance of isotope from the hemisphere was monitored by 15 highly collimated detectors. 9 Falling count rates from each counter were recorded on a 16-channel digital magnetic tape and the data processed by computer to give regional results for the five CBF variables:…”

Section: Methodsmentioning

confidence: 99%

“…8 Fifteenminute isotope clearance curves were recorded at two levels of Paco,; the starting level was between 39 to 46 mm Hg (normocapnia) and a difference of at least 10 mm Hg was obtained between the normocapnic and following hypocapnic measurement. The intracarotid injection method of CBF measurement was used as previously described 9 and each paired study was followed immediately by angiography.…”

Section: Methodsmentioning

confidence: 99%

Cerebrovascular CO ₂ Reactivity of the Fast and Slow Clearing Compartments

Iliff

Zilkha

Boulay

et al. 1974

Stroke

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Cerebro vascular CO 2 Reactivity of the Fast and Slow Clearing Compartments• Regional cerebral blood flow measurements have been made at two levels of Paco, using the clearance of 133 Xenon injected into the internal carotid artery. Specific and percent changes in blood flow per mm Hg change in Paco, (CO 2 reactivity) have been calculated for the fast and slow clearing tissue (Ff and Fs) and F initial. Mean hemisphere CO 2 reactivity was marginally greater in the fast clearing tissue than in the slow clearing tissue (P = 0.05). On a regional basis the greater CO 2 reactivity of Ff over Fs was significant in five areas (P < 0.05). A strong positive linear correlation between mean specific reactivity and conductance (the reciprocal of resistance) has been demonstrated for Ff and Fs and confirmed in the F initial.

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Regional blood flow in the normal cerebral hemisphere.

Cited by 139 publications

References 7 publications

Accuracy and Precision of the Computerized Brain Atlas Programme for Localization and Quantification in Positron Emission Tomography

Accuracy and Precision of the Computerized Brain Atlas Programme for Localization and Quantification in Positron Emission Tomography

Measurement of Regional Cerebral Blood Flow With ¹³³ Xenon and a Multiple-Crystal Scintillation Camera

Cerebrovascular CO ₂ Reactivity of the Fast and Slow Clearing Compartments

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Regional blood flow in the normal cerebral hemisphere.

Cited by 139 publications

References 7 publications

Accuracy and Precision of the Computerized Brain Atlas Programme for Localization and Quantification in Positron Emission Tomography

Accuracy and Precision of the Computerized Brain Atlas Programme for Localization and Quantification in Positron Emission Tomography

Measurement of Regional Cerebral Blood Flow With 133 Xenon and a Multiple-Crystal Scintillation Camera

Cerebrovascular CO 2 Reactivity of the Fast and Slow Clearing Compartments

Contact Info

Product

Resources

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Measurement of Regional Cerebral Blood Flow With ¹³³ Xenon and a Multiple-Crystal Scintillation Camera

Cerebrovascular CO ₂ Reactivity of the Fast and Slow Clearing Compartments