Regional Cerebral Blood Flow. Evaluation of the Microsphere Technique

Shulman, Kenneth I.; Furman, Mark; Rosende, R.

doi:10.1007/978-3-642-65814-3_40

Cited by 8 publications

(2 citation statements)

References 8 publications

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“…The values of LCMRgl were comparable with previously reported values for anesthetized cats (Ginsberg et a!., 1977). The LCBF values in the various structures were similar to data obtained by the microsphere tech nique in the anesthetized cat (Shulman et a!., 1975). There was no apparent difference between LCBFl measured at the end of the sham insult period and LCBF2 measured at the end of the study.…”

Section: Lcbf and Lcmrgl In The Sham Animalssupporting

confidence: 89%

Regional Flow-Metabolism Couple following Middle Cerebral Artery Occlusion in Cats

Tanaka¹,

Greenberg²,

Gonatas

et al. 1985

J Cereb Blood Flow Metab

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Summary:The regional flow-metabolism couple was studied during the recovery period after I h of left middle cerebral artery (MCA) occlusion in cats. Local CBF (LCBF) was assessed at the end of ischemia as well as at the end of 4 h of recirculation by the microsphere tech nique. Local CMRgl (LCMRgl) was measured at the end of the recirculation period with [14C12-deoxyglucose. His tology was evaluated by light microscopy from coronal brain blocks adjacent to those used for the determination of LCBF and LCMRgl. When LCBF in the central and peripheral MCA territories during the recovery period was between 40 and 115% of the value in sham occlusion studies, LCMRgl was greater than the control level found in the sham studies, and was accompanied by slight his tological damage. This finding suggests that anaerobic glycolysis may persist after transient ischemia in spite of

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Section: Lcbf and Lcmrgl In The Sham Animalssupporting

confidence: 89%

Regional Flow-Metabolism Couple following Middle Cerebral Artery Occlusion in Cats

Tanaka¹,

Greenberg²,

Gonatas

et al. 1985

J Cereb Blood Flow Metab

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“…Six male volunteers (age [21][22][23][24][25][26] were studied by tomographically measuring the distribution of 13 N in the brain after an i.v. bolus injection of 10 to 15 mCi of 13 NH,.…”

Section: Human Studiesmentioning

confidence: 99%

Cerebral extraction of N-13 ammonia: its dependence on cerebral blood flow and capillary permeability -- surface area product.

Phelps¹,

Huang²,

Hoffman³

et al. 1981

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This work was supported by DOE contract #DE-AMO3-76-SF00012 and NIH Grants ROI-GM-24839-01 and 515654-01. and amino acid metabolism. However, due to the complexities involved in the extraction and retention of 18 NH, in these organs, more extensive studies are required to better understand the potential uses of this tracer.Phelps et al., 4 using positron computed tomography (PCT) with normal volunteers, showed that the relative "N concentrations in structures of the brain were in good agreement with the relative capillary densities and/or cerebral blood flow (CBF). Subsequently, Phelps et al. 6 demonstrated in the monkey that the unidirectional extraction fraction of 18 NH, by the brain was 1) less than 100% at normal values of CBF, 2) inversely related to CBF, 3) unaffected by blood ammonia concentrations from 80 to 1400 /xg% and insensitive to changes in arterial blood pH over the range of 7.2 and 7.7, 4) decreased by about 24% during hypoglycemic coma and 5) was limited by capillary permeability.

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Alteration in Choroid-Plexus Blood Flow and Cerebrospinal- Fluid Formation by Increased Ventricular Pressure

Pollay

Stevens

Roberts

1983

Neurobiology of Cerebrospinal Fluid 2

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Regional Cerebral Blood Flow. Evaluation of the Microsphere Technique

Cited by 8 publications

References 8 publications

Regional Flow-Metabolism Couple following Middle Cerebral Artery Occlusion in Cats

Regional Flow-Metabolism Couple following Middle Cerebral Artery Occlusion in Cats

Cerebral extraction of N-13 ammonia: its dependence on cerebral blood flow and capillary permeability -- surface area product.

Alteration in Choroid-Plexus Blood Flow and Cerebrospinal- Fluid Formation by Increased Ventricular Pressure

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