Regional Cerebral Glucose Metabolism and Gait Speed in Healthy Community-Dwelling Older Women

Sakurai, Ryota; Fujiwara, Yoshinori; Yasunaga, Masashi; Takeuchi, Rumi; Murayama, Yoh; Ohba, Hiromi; Sakuma, Naoko; Suzuki, Hiroyuki; Oda, Kazuhiro; Sakata, Muneyuki; Toyohara, Jun; Ishiwata, Kiichi; Shinkai, Shoji; Ishii, Kenji

doi:10.1093/gerona/glu093

Cited by 37 publications

(38 citation statements)

References 41 publications

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“…The approach employed and the results obtained in the present study are considered to endorse these previous reports. Furthermore, various previous reports [17][18][19][20][21] have suggested an association between changes in exercise speed and improvement in brain function. These findings suggest that physical training that involves being aware of the focused attention (as adopted in this intervention method) is more likely to lead to higher brain activity and improvement in cognitive function than monotonous physical training.…”

Section: Discussionmentioning

confidence: 92%

Combined Exercise and Cognitive Training System for Dementia Patients: A Randomized Controlled Trial

Okamura¹,

Otani²,

Shimoyama³

et al. 2018

Dement Geriatr Cogn Disord

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Background/Aims: We investigated the efficacy of a combined exercise and cognitive training system that we devised for improvement of attention and concentration, cognition, and activities of daily living in older adults with dementia. Methods: A total of 100 dementia patients were randomly assigned to an intervention group or a control group. The intervention group was subjected to a combined exercise and cognitive training for 6 consecutive weeks. Evaluations were performed using the Trail Making Test-Part A, the Mini-Mental State Examination, and an N-type activities of daily living evaluation scale for the elderly. Results: A comparison of the changes in scores on the evaluation scales between the intervention group and the control group showed significant interactions for all scores. Conclusions: The combined system is effective in increasing attention and concentration and improving cognitive function and activities of daily living in dementia patients.

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Section: Discussionmentioning

confidence: 92%

Combined Exercise and Cognitive Training System for Dementia Patients: A Randomized Controlled Trial

Okamura¹,

Otani²,

Shimoyama³

et al. 2018

Dement Geriatr Cogn Disord

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“…Other neuroimaging studies have linked functional brain networks during rest with single-task gait (Sakurai et al 2014) and dual-task gait (Yuan et al 2015). The first study found that cerebral glucose metabolism in the PFC, PCC, and parietal cortex was associated with single-task gait and these regions were thought to be constitutive parts of the default mode network (Sakurai et al 2014).…”

Section: Discussionmentioning

confidence: 99%

“…The first study found that cerebral glucose metabolism in the PFC, PCC, and parietal cortex was associated with single-task gait and these regions were thought to be constitutive parts of the default mode network (Sakurai et al 2014). The second study found that dual-task gait was associated with greater connectivity in dorsolateral prefrontal regions of the left fronto-parietal resting state network (Yuan et al 2015).…”

Section: Discussionmentioning

confidence: 99%

Gray matter volume and dual-task gait performance in mild cognitive impairment

Doi

Blumen

Verghese

et al. 2016

Brain Imaging and Behavior

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Dual-task gait performance is impaired in older adults with mild cognitive impairment, but the brain substrates associated with dual-task gait performance are not well-established. The relationship between gray matter and gait speed under single-task and dual-task conditions (walking while counting backward) was examined in 560 seniors with mild cognitive impairment (non-amnestic mild cognitive impairment: n = 270; mean age = 72.4 yrs., 63.6 % women; amnestic mild cognitive impairment: n = 290; mean age = 73.4 yrs., 45.4 % women). Multivariate covariance-based analyses of magnetic resonance imaging data, adjusted for potential confounders including single-task gait speed, were performed to identify gray matter patterns associated with dual-task gait speed. There were no differences in gait speed or cognitive performance during dual-task gait between individuals with non-amnestic mild cognitive impairment and amnestic mild cognitive impairment. Overall, increased dual-task gait speed was associated with a gray matter pattern of increased volume in medial frontal gyrus, superior frontal gyrus, anterior cingulate, cingulate, precuneus, fusiform gyrus, middle occipital gyrus, inferior temporal gyrus and middle temporal gyrus. The relationship between dual-task gait speed and brain substrates also differed by mild cognitive impairment subtype. Our study revealed a pattern of gray matter regions associated with dual-task performance. Although dual-task gait performance was similar in amnestic and non-amnestic mild cognitive impairment, the gray matter patterns associated with dual-task gait performance differed by mild cognitive impairment subtype. These findings suggest that the brain substrates supporting dual-task gait performance in amnestic and non-amnestic subtypes are different, and consequently may respond differently to interventions, or require different interventions.

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“…A recent study indicated that regional cerebral metabolic rates of glucose (rCMRglu) in the prefrontal cortex were associated with control of gait speed . Another recent cross‐sectional study reported that slower maximum walking speed was associated with lower rCMRglu in the prefrontal, posterior cingulate, and parietal cortices, independent of major health factors …”

Section: Discussionmentioning

confidence: 99%

One‐Year Change in the Japanese Version of the Montreal Cognitive Assessment Performance and Related Predictors in Community‐Dwelling Older Adults

Suzuki

Kawai

Hirano

et al. 2015

J American Geriatrics Society

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Regional Cerebral Glucose Metabolism and Gait Speed in Healthy Community-Dwelling Older Women

Cited by 37 publications

References 41 publications

Combined Exercise and Cognitive Training System for Dementia Patients: A Randomized Controlled Trial

Combined Exercise and Cognitive Training System for Dementia Patients: A Randomized Controlled Trial

Gray matter volume and dual-task gait performance in mild cognitive impairment

One‐Year Change in the Japanese Version of the Montreal Cognitive Assessment Performance and Related Predictors in Community‐Dwelling Older Adults

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