Regional cortical blood flow changes following sodium lactate infusion in Alzheimer's disease

Kálmán, János; Palotás, András; Kis, Gabriella; Boda, Krisztina; Túri, Piroska; Bari, Ferenc; Domoki, Ferenc; Dóda, Ildikó; Vincze, Gábor; Séra, Teréz; Csernay, L.; Janka, Zoltán; Pajor, László

doi:10.1111/j.1460-9568.2005.03924.x

Cited by 9 publications

(5 citation statements)

References 41 publications

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“…Overall, the function of previously unappreciated exerkines represents a promising area of research in the field of NDs. For instance, the infusion of sodium lactate did not enhance semantic categorization processes in AD patients (Kalman et al, 2005a), yet it altered cortical blood flow dynamics in these individuals (Kalman et al, 2005b). Although the clinical application of these exercise-related factors remains relatively underexplored, the utilization of analogs, such as SZR104 and KYNA-amide, analogs of KYNA, provides novel perspectives in clinical research.…”

Section: Discussionmentioning

confidence: 99%

“…Tryptophan (Trp) is one of the essential amino acids for various physiological functions, which should be obtained through food intake (Comai et al, 2020). It is widely distributed in different tissues and organs throughout the body (Kaluzna-Czaplinska et al, 2019). Trp undergoes different secondary degradation pathways, including decarboxylation of tryptophan to tryptamine, transamination to indol-3-yl pyruvic acid, and hydroxylation to 5-hydroxytryptamine (5-HT), which contribute to its overall metabolic profile (Cervenka et al, 2017).…”

Section: Kyn Pathway and Central Toxic Effectsmentioning

confidence: 99%

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The function of previously unappreciated exerkines secreted by muscle in regulation of neurodegenerative diseases

Bian,

Wang,

Wang

et al. 2024

Front. Mol. Neurosci.

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The initiation and progression of neurodegenerative diseases (NDs), distinguished by compromised nervous system integrity, profoundly disrupt the quality of life of patients, concurrently exerting a considerable strain on both the economy and the social healthcare infrastructure. Exercise has demonstrated its potential as both an effective preventive intervention and a rehabilitation approach among the emerging therapeutics targeting NDs. As the largest secretory organ, skeletal muscle possesses the capacity to secrete myokines, and these myokines can partially improve the prognosis of NDs by mediating the muscle-brain axis. Besides the well-studied exerkines, which are secreted by skeletal muscle during exercise that pivotally exert their beneficial function, the physiological function of novel exerkines, e.g., apelin, kynurenic acid (KYNA), and lactate have been underappreciated previously. Herein, this review discusses the roles of these novel exerkines and their mechanisms in regulating the progression and improvement of NDs, especially the significance of their functions in improving NDs’ prognoses through exercise. Furthermore, several myokines with potential implications in ameliorating ND progression are proposed as the future direction for investigation. Elucidation of the function of exerkines secreted by skeletal muscle in the regulation of NDs advances the understanding of its pathogenesis and facilitates the development of therapeutics that intervene in these processes to cure NDs.

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Section: Discussionmentioning

confidence: 99%

Section: Kyn Pathway and Central Toxic Effectsmentioning

confidence: 99%

The function of previously unappreciated exerkines secreted by muscle in regulation of neurodegenerative diseases

Bian,

Wang,

Wang

et al. 2024

Front. Mol. Neurosci.

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“…The insufficient acetylcholinergic innervation [31] of the parietal (P3, P4) regions in advanced AD might be responsible for the decreased vascular reactivity of the examined brain areas after sodium lactate and might have additional influence on the brain circulation and metabolism as it was demonstrated by our former SPECT brain imaging study on similar AD population [24]. This could be a possible cause why we did not find any significant EEG power and SL changes after the sodium lactate infusion mainly over these brain territories.…”

Section: Discussionmentioning

confidence: 99%

“…The probands were diagnosed with moderate‐to‐severe dementia syndrome as their Mini‐Mental State Examination (MMSE) score was 13.4 ± 5.72 points. Five of 12 patients (three female and two men) participated in an earlier study [24], where the lactate effect on the regional cerebral blood flow (rCBF) was studied by 99m TC‐HMPAO SPECT as well. Their average age was 73.6 ± 2.30 years.…”

Section: Methodsmentioning

confidence: 99%

“…Lactate is an important metabolite of the glucolytic process, which can be metabolized in the brain [21]. It is a metabolic vasodilator that is known to provoke increased CBF in healthy adults [22,23], but it does not normalize the decreased CBF in AD patients [24]. The aim of the present study was therefore to investigate the effect of sodium lactate infusion in AD as reflected in resting state EEG by frequency and SL analyses of the patients.…”

Section: Introductionmentioning

confidence: 99%

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Sodium lactate differently alters relative EEG power and functional connectivity in Alzheimer’s disease patients’ brain regions

Járdánházy¹,

Járdánházy²,

Kálmán³

2008

Euro J of Neurology

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Bilateral temporo-parietal hypoperfusion and decreased glucose metabolism are characteristic in vivo findings in Alzheimer's disease (AD). Lactate is a metabolic vasodilator and is known to induce increased cerebral blood flow in healthy adults. The present study addresses the issue whether sodium lactate infusion affects functional state and resulting electroencephalographic patterns of AD patients. Twelve late-onset sporadic AD probands participated in this self-control study. The relative power and synchronization likelihood (SL) values of the electroencephalographic samples were calculated and compared off-line before and after sodium lactate infusion (0.5 M, 5 ml/kg body weight). Based on the reactivity to sodium lactate the scalp could be divided into three parts; no significant changes were seen in the seriously damaged (P3-P4) areas. The moderately affected regions in the close neighborhood showed a paradoxic inactivation with electroencephalographic slowing, a likely consequence of the metabolic-like steal effect of the near-normal areas outside. These results indicate a diminished vascular and/or metabolic reserve capacity to sodium lactate challenge in AD and confirm the formerly described electroencephalographic abnormalities.

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Lactate infusion as therapeutical intervention: a scoping review

et al. 2022

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Traditionally, clinicians consider lactate as a waste product of anaerobic glycolysis. Interestingly, research has shown that lactate may serve as an alternative fuel for the brain to protect it against harm. The increasing scientific awareness of the potential beneficial side of lactate, however, is entering the clinic rather slowly. Following this, and realizing that the application of potential novel therapeutic strategies in pediatric populations often lags behind the development in adults, this review summarizes the key data on therapeutic use of intravenous infusion of sodium lactate in humans. PubMed and clinicaltrial.gov were searched up until November 2021 focusing on interventional studies in humans. Thirty-four articles were included in this review, with protocols of lactate infusion in adults with diabetes mellitus, traumatic brain injury, Alzheimer’s disease, and cardiac disease. One study on lactate infusion in children was also included. Results of our literature search show that sodium lactate can be safely administrated, without major side effects. Additionally, the present literature clearly shows the potential benefits of therapeutic lactate infusion under certain pathological circumstances, including rather common clinical conditions like traumatic brain injury.Conclusion: This review shows that lactate is a save, alternative energy source for the adult brain warranting studies on the potential therapeutic effects of sodium lactate infusion in children. What is Known:• Lactate is generally considered a waste product of anaerobic glycolysis. However, lactate also is an alternative fuel for different organs, including the brain.• Lactate infusion is not incorporated in standard care for any patient population. What is New:• Thirty-four studies investigated the therapeutic use of intravenous sodium lactate in different patient populations, all with different study protocols.• Literature shows that lactate infusion may have beneficial effects in case of hypoglycemia, traumatic brain injury, and cardiac failure without the risk of major side effects.

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Regional cortical blood flow changes following sodium lactate infusion in Alzheimer's disease

Cited by 9 publications

References 41 publications

The function of previously unappreciated exerkines secreted by muscle in regulation of neurodegenerative diseases

The function of previously unappreciated exerkines secreted by muscle in regulation of neurodegenerative diseases

Sodium lactate differently alters relative EEG power and functional connectivity in Alzheimer’s disease patients’ brain regions

Lactate infusion as therapeutical intervention: a scoping review

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