Regional distribution of tyrosine hydroxylase in rat brain<sup>1</sup>

Cicero, Theodore J.; Sharpe, Lawrence G.; Robins, Eli; Grote, S. S.

doi:10.1111/j.1471-4159.1972.tb05136.x

Cited by 49 publications

(2 citation statements)

References 7 publications

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“…Our experiments have also demonstrated that DMPH4 is a required cofactor in the hydroxylation of tyrosine and tryptophan in the brain since we were unable to detect any activity in the absence of DMPH4. These results are particularly in good agreement with previous reports (Nagatsu et al, 1964;Nagatsu et al, 1971;Petrack et al, 1968;Cicero et al, 1972;and Goldstein and FreukeI, 1971).…”

Section: Discussionsupporting

confidence: 95%

Effect of chronically administered L-Dopa on Dopa/5HTP decarboxylase and tyrosine and tryptophan hydroxylases in cat brain

1973

J. Neural Transmission

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Summary --R6sum6The activity of tyrosine and tryptophan hydroxylases and of Dopa/ 5-HTP decarboxylase was measured in different structures of the brain of cats administered L-Dopa (100 mg/kg/day, per os) during several consecutive days: The activity of tyrosine hydroxylase which i.s unchanged after 4 and 7 days of treatment, respectively, is significantly decreased ai~ 21 days of L-Dopa. The activity of tryptophan hydroxylase is normal a~er 4 days of L-Dopa but it is significantly decreased ai~ 7 and 21 days of L-Dopa, respectively. The activity of decarboxylase is normal after 4 days of L-Dopa but it is significantly increased after 7 and 21 days of L-Dopa, respectively.

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Section: Discussionsupporting

confidence: 95%

Effect of chronically administered L-Dopa on Dopa/5HTP decarboxylase and tyrosine and tryptophan hydroxylases in cat brain

1973

J. Neural Transmission

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“…The presence of TH in the IC has been previously reported but was not described in detail in the rat (Cicero et al, 1972;Hokfelt et al, 1976;Jaeger and Joh, 1983;Reuss et al, 1999;Ryu et al, 2000). Fibers that were immunopositive for another enzyme in the catecholamine pathway, dopamine beta hydroxylase (DBH), have also been reported in the IC (Klepper and Herbert, 1991).…”

Section: Introductionmentioning

confidence: 85%

Tyrosine hydroxylase in rat auditory midbrain: Distribution and changes following deafness

2005

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Developmental changes of RNA, DNA, lipid, protein and glutamic acid decarboxylase of rat forebrain, anterior midbrain, posterior midbrain, and cerebellum

Gaitonde

Tannock

Evans

1978

J of Neuroscience Research

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The concentration of glutamic acid decarboxylase (/*moles of glutamic acid decarboxylated/hr/gm) was found higher in the anterior midbrain than in several other regions of the adult rat brain. It was the highest in the anterior colliculus.posterior midbrain showed that the four regions behaved as distinct organs as regards the deposition of structural constituents and the activity of glutamic acid decarboxylase. There was evidence of postnatal cell acquisition by the four regions. The rate of accretion of DNA, RNA, phospholipid, and protein was the highest in the cerebellum, but that of glutamic acid decarboxylase was highest in the forebrain during postnatal development. The results indicated that the average size of the cerebellar cell in the adult rat was smaller than that of the cell of the forebrain, anterior midbrain, and posterior midbrain. The phospholipid content compared to that of protein was higher in the posterior midbrain than in the other three brain regions.The presence of fully differentiated GABAergic neurons in the cerebellum appear by the end of the first postnatal week.A developmental study of the forebrain, cerebellum, anterior midbrain, and

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Regional distribution of tyrosine hydroxylase in rat brain¹

Cited by 49 publications

References 7 publications

Effect of chronically administered L-Dopa on Dopa/5HTP decarboxylase and tyrosine and tryptophan hydroxylases in cat brain

Effect of chronically administered L-Dopa on Dopa/5HTP decarboxylase and tyrosine and tryptophan hydroxylases in cat brain

Tyrosine hydroxylase in rat auditory midbrain: Distribution and changes following deafness

Developmental changes of RNA, DNA, lipid, protein and glutamic acid decarboxylase of rat forebrain, anterior midbrain, posterior midbrain, and cerebellum

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Regional distribution of tyrosine hydroxylase in rat brain1

Cited by 49 publications

References 7 publications

Effect of chronically administered L-Dopa on Dopa/5HTP decarboxylase and tyrosine and tryptophan hydroxylases in cat brain

Effect of chronically administered L-Dopa on Dopa/5HTP decarboxylase and tyrosine and tryptophan hydroxylases in cat brain

Tyrosine hydroxylase in rat auditory midbrain: Distribution and changes following deafness

Developmental changes of RNA, DNA, lipid, protein and glutamic acid decarboxylase of rat forebrain, anterior midbrain, posterior midbrain, and cerebellum

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Regional distribution of tyrosine hydroxylase in rat brain¹