Regional Expression of Aquaporin 1, 4, and 9 in the Brain During Pregnancy

Wiegman, Marchien J.; Bullinger, Lisa V.; Kohlmeyer, Meghan M.; Hunter, Tim; Cipolla, Marilyn J.

doi:10.1177/1933719107311783

Cited by 14 publications

(14 citation statements)

References 37 publications

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“…AQP9 labelling has previously been reported in astrocytes in the periventricular parenchyma and glia limitans, in endothelial cells at the border of the subarachnoid space, and in neurons, particularly catecholaminergic neurons (Li et al 2005;Wiegman et al 2008). The current study showed that AQP9 was expressed in astrocytes and neurons after pMCAO.…”

Section: Discussionsupporting

confidence: 74%

Phosphorylation of p38 MAPK mediates aquaporin 9 expression in rat brains during permanent focal cerebral ischaemia

et al. 2015

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Aquaporin 9 (AQP9), an aquaglyceroporin, is an important aquaporin in the brain. This study examined the expression patterns of AQP9 and p38 mitogen-activated protein kinases (MAPK) in ischaemic brains from rats with permanent middle cerebral artery occlusion (pMCAO) to elucidate the function and regulation of AQP9 after ischaemia. AQP9 was co-localised with glial fibrillary acidic protein-positive astrocytes and neuronal nuclei-positive neurons in rat brains. Expression of AQP9 increased continuously until 24 h after pMCAO in the ischaemic core region and the border region. Importantly, this increase in expression of AQP9 correlated with brain oedema. AQP9 expression was predominant in astrocytes within 3 h after pMCAO and then in neurons 6 h after pMCAO. Phosphorylated p38 MAPK was also induced in the ischaemic core region and the border region at different time points after pMCAO. Interestingly, intracerebroventricular injection of the p38 MAPK inhibitor SB203580 attenuated AQP9 expression after pMCAO. Taken together, these results indicate that dynamic changes in AQP9 expression, mediated in part via the p38 MAPK signal transduction pathway, may contribute to the development of cerebral oedema after brain ischaemia.

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Section: Discussionsupporting

confidence: 74%

Phosphorylation of p38 MAPK mediates aquaporin 9 expression in rat brains during permanent focal cerebral ischaemia

et al. 2015

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“…94–98 Interestingly, AQP4 is increased in the brain during pregnancy. 99 100 . The effect of increased expression of AQP4 in the brain during pregnancy is not clear, but could affect seizure threshold as AQP4 knockout mice were shown to be less susceptible to seizure, suggesting elevated AQP4 lowers the seizure threshold.…”

Section: Mechanisms Of Seizure During Preeclampsiamentioning

confidence: 99%

Seizures in Women With Preeclampsia: Mechanisms and Management

Cipolla

Kraig

2011

Fet. Matern. Med. Rev.

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Eclampsia is defined in the obstetrical literature as the occurrence of unexplained seizure during pregnancy in a woman with preeclampsia. In the Western world, the incidence of eclampsia is ~1 per 2000 to 1 per 3000 pregnancies, but the incidence is 10-fold higher in tertiary referral centers and undeveloped countries where there is poor prenatal care, and in multi-fetal gestations. Nearly 1 in 50 women with eclampsia die as do 1 in 14 of their offspring, and mortality rates are considerably higher in undeveloped countries. Eclampsia is also associated with significant life-threatening complications, including neurological events. Seizure acutely can cause stroke, haemorrhage, oedema and brain herniation and thus lead to epilepsy and cognitive impairment later in life.

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“…Among this family of water channels, aquaporin 9 demonstrates the greatest homology to aquaporins 3 and 7, and the least molecular likeness to aquaporin 1 [31]. As well as being expressed in organs such as the human liver [31], brain [32], osteoclast cells [34], Figure 1. Box and whisker plot of aquaporin 9 mRNA expression in chorioamniotic membranes from women at term.…”

Section: What Is Aquaporin 9?mentioning

confidence: 99%

“…In a series of investigations using a rat model, Lindsay and Murphy [61] have reported a role for aquaporins in luminal fluid changes. Aquaporin 9 was localized to the apical glandular epithelium with increased immunofluorescent staining after implantation and the authors suggest its role in the re-absorption of glandular contents; and (3) recently, in an animal model, Wiegman et al [32] described the differential and regional expression of aquaporin 9 in the rat brain during pregnancy. The authors found that aquaporin 9 distribution did not differ between the pregnant and the non-pregnant state, but that its expression decreased in the posterior cerebrum when comparing non-pregnant and latepregnancy animals, and in the cerebellum in both mid-pregnant and late-pregnant rats compared with non-pregnant animals.…”

Section: Normal Pregnancy and Aquaporinmentioning

confidence: 99%

“…These findings support the role of aquaporin 9 in metabolism. Aquaporin 9 expression has been reported in human organs and cells including the liver [31], brain [32], testis [33], osteoclast cells [34], placenta [35], peripheral leukocytes [31], and has been localized in human chorioamniotic membranes [36]. Given the significant role of this aquaglyceroporin in solute transport, aquaporin 9 may be involved both in the maintenance of amniotic fluid composition, as well as in the supply of precursor substrates for cellular metabolism.…”

Section: Introductionmentioning

confidence: 99%

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Fetal membranes as an interface between inflammation and metabolism: Increased Aquaporin 9 expression in the presence of spontaneous labor at term and chorioamnionitis

Mittal¹,

Romero²,

Mazaki‐Tovi³

et al. 2009

The Journal of Maternal-Fetal & Neonatal Medicine

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Objective. Aquaporin 9 (AQP9) is a water channel protein characterized by its high permeability to nutrients such as lactate and glycerol, as well as urea and other small solutes. These unique properties of AQP9 suggest that this molecule may play a role in the modulation of nutrient flux through the fetal membranes in conditions associated with increased metabolic demand, such as spontaneous labor and inflammation. The objective of this study was to determine the expression of AQP9 in the chorioamniotic membranes from women with and without term labor, as well as those with preterm prelabor rupture of membranes (PPROM) with and without histologic chorioamnionitis. Study design. A cross-sectional study was performed which included patients in the following groups: (1) term not in labor (TNL; n ¼ 14); (2) term, spontaneous labor (n ¼ 14); and (3) PPROM with (n ¼ 20) and without (n ¼ 17) histologic chorioamnionitis. AQP9 mRNA expression in fetal membranes was quantified using quantitative real-time reverse transcription-polymerase chain reaction and analyzed with a linear model including gestational age as a covariate. Results. (1) AQP9 mRNA expression was identified in all chorioamniotic membrane specimens; (2) AQP9 expression in fetal membranes was significantly higher in spontaneous term labor when compared with TNL (fold change 3.6; p ¼ 0.01); and (3) Among patients with PPROM, the presence of histologic chorioamnionitis was associated with a higher expression of AQP9 in the chorioamniotic membranes compared with those from women without histologic chorioamnionitis (fold change 8.7; p 5 0.001). Conclusion. Aquaporin 9 mRNA expression is higher in the fetal membranes from patients with spontaneous term labor and those with PPROM and histologic chorioamnionitis. These findings are novel, and suggest a role for aquaporin 9 in membrane-mediated transfer of nutrients to support the increased metabolic demands associated with the host immune response of the terminal pathway of parturition and histologic chorioamnionitis.

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Regional Expression of Aquaporin 1, 4, and 9 in the Brain During Pregnancy

Cited by 14 publications

References 37 publications

Phosphorylation of p38 MAPK mediates aquaporin 9 expression in rat brains during permanent focal cerebral ischaemia

Phosphorylation of p38 MAPK mediates aquaporin 9 expression in rat brains during permanent focal cerebral ischaemia

Seizures in Women With Preeclampsia: Mechanisms and Management

Fetal membranes as an interface between inflammation and metabolism: Increased Aquaporin 9 expression in the presence of spontaneous labor at term and chorioamnionitis

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