Regional FDG Lumped Constant in the Normal Human Brain

Graham, Michael M.; Muzi, Mark; Spence, Alexander M.; O’Sullivan, Finbarr; Lewellen, T.K.; Link, Jeanne; Krohn, Kenneth A.

doi:10.1016/b978-012285751-5/50020-x

Cited by 61 publications

(95 citation statements)

References 11 publications

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“…Here, the lumped constant was set to 0.89 (28,29), and although some studies may have used different values, this factor affects only the absolute values in cerebral metabolic rate of glucose (CMRGlu) but not K i or task-specific changes in glucose metabolism. The actual lumped constant is thus of little relevance as long as it is consistently used within a study.…”

Section: Quantification With Bolus Applicationmentioning

confidence: 99%

Quantification of Task-Specific Glucose Metabolism with Constant Infusion of¹⁸F-FDG

et al. 2016

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The investigation of cerebral metabolic rate of glucose (CMRGlu) at baseline and during specific tasks previously required separate scans with the drawback of high intrasubject variability. We aimed to validate a novel approach to assessing baseline glucose metabolism and task-specific changes in a single measurement with a constant infusion of 18 F-FDG. Methods: Fifteen healthy subjects underwent two PET measurements with arterial blood sampling. As a reference, baseline CMRGlu was quantified from a 60-min scan after 18 F-FDG bolus application using the Patlak plot (eyes closed). For the other scan, a constant radioligand infusion was applied for 95 min, during which the subjects opened their eyes at 10-20 min and 60-70 min and tapped their right thumb to their fingers at 35-45 min and 85-95 min. The constant-infusion scan was quantified in two steps. First, the general linear model was used to fit regional time-activity curves with regressors for baseline metabolism, task-specific changes for the eyes-open and finger-tapping conditions, and movement parameters. Second, the Patlak plot was used for quantification of CMRGlu. Multiplication of the baseline regressor by β-values from the general linear model yielded regionally specific time-activity curves for baseline metabolism. Further, taskspecific changes in metabolism are directly proportional to changes in the slope of the time-activity curve and hence to changes in CMRGlu. Results: Baseline CMRGlu from the constant-infusion scan matched that from the bolus application (test-retest variability, 1.1% ± 24.7%), which was not the case for a previously suggested approach (variability, −39.9% ± 25.2%, P , 0.001). Task-specific CMRGlu increased in the primary visual and motor cortices for eyes open and finger tapping, respectively (P , 0.05, familywise errorcorrected), with absolute changes of up to 2.1 μmol/100 g/min and 6.3% relative to baseline. For eyes open, a decreased CMRGlu was observed in default-mode regions (P , 0.05, familywise errorcorrected). CMRGlu quantified with venous blood samples (n 5 6) showed excellent agreement with results obtained from arterial samples (r . 0.99). Conclusion: Baseline glucose metabolism and taskspecific changes can be quantified in a single measurement with constant infusion of 18 F-FDG and venous blood sampling. The high sensitivity and regional specificity of the approach offer novel possibilities for functional and multimodal brain imaging.

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Section: Quantification With Bolus Applicationmentioning

confidence: 99%

Quantification of Task-Specific Glucose Metabolism with Constant Infusion of¹⁸F-FDG

et al. 2016

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“…The LC FDG in gliomas was 1.40 (AE 0.46, SD) with a range from 0.72 to 3.10 whereas in non-tumorbearing contralateral brain it was 0.86 (AE 0.14) with a range from 0.61 to 1.21. In a series of 10 normal subjects the value for brain was 0.89 (AE 0.08) [Graham et al, 2002].…”

Section: Hk Phosphorylation Ratio ðPrþmentioning

confidence: 99%

Molecular imaging of regional brain tumor biology

2002

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Energy metabolism measurements in gliomas in vivo are now performed widely with positron emission tomography (PET). This capability has developed from a large number of basic and clinical science investigations that have cross fertilized one another. This article presents several areas that exemplify questions that have been explored over the last two decades. While the application of PET with [(18)F]-2-fluoro-2-deoxyglucose (FDG-PET) has proven useful for grading and prognosis assessments, this approach is less clinically suitable for assessing response to therapy, even though results to date raise very intriguing biological questions. Integration of metabolic imaging results into glioma therapy protocols is a recent and only preliminarily tapped method that may prove useful in additional trials that target DNA or membrane biosynthesis, or resistance mechanisms such as hypoxia. There are exciting future directions for molecular imaging that will undoubtedly be fruitful to explore, especially apoptosis, angiogenesis and expression of mutations of genes, e.g., epidermal growth factor receptor, that promote or suppress cellular malignant behavior.

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“…Düzeltme faktörleri (toplu sabit "lumped constant": LC =0,42-0,82) ile FDG değerleri glukoz metabolizmasını yansıtan değerlere dönüştürülebilir (20,21). Bu yolla glukoz metabolizma hızı kesin birimler ile ölçülebilir (örn.…”

Section: Tamglukozmetabolizmasıunclassified

TSNM Procedure Guideline for PET Brain Imaging using F-18 FDG

Yaylalı¹,

Koç²,

Aydın³

et al. 2015

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ÖzetBu kılavuzda kısaca F-18 FDG ile beyin görüntülemenin nasıl yapılması gerektiği konusunda bu günkü bilgilerimiz ve Türkiye Nükleer Tıp Derneği tarafından oluşturulan "Nöropsikiyatri" çalışma grubunun düşünceleri özetlenmiştir. Bu kılavuzun amacı F-18 FDG ile beyin PET görüntülemede standart bir yaklaşım sağlamak ortak protokollerle ve raporlama örnekleriyle sonuçlarımızın birbiriyle karşılaştırılabilir hale gelmesine yardımcı olmaktır. Bu kılavuz daha önce Nükleer Tıp Derneği'nin oluşturduğu kılavuzların ve EANM kılavuzlarının yenilenmiş versiyonu olup özellikle yeni hibrid görüntülüme yöntemleri (PET/BT ve PET/MR) ile güncellenen parametreleri de içermektedir. Bu kılavuzda görüntüleme yöntemleri, uygulamalar ve raporlamalar ile ilgili tüm ayrıntılar hakkında bilgiler özetlenmiş olup verilen tavsiyelerde ülkemiz yasa ve yönetmelikleri dikkate alınmıştır. Anahtar kelimeler: FDG, demans, epilepsi Çıkar Çatışması: Yazarlar bu makale ile ilgili olarak herhangi bir çıkar çatışması bildirmemiştir. AbstractThis guideline summarizes our recent knowledge and the opinions of the Brain Interest group, created by the Turkish Society of Nuclear Medicine, about how to perform F-18 FDG brain imaging briefly. The aim of this guideline is to help to generate similar results by providing a standardized approach in F-18 FDG brain imaging with common protocols and report sampling. This guideline contains information of previous guidelines by the Turkish Society of Nuclear Medicine and the European Association of Nuclear Medicine latest versions and additionally updated parameters about new hybrid modalities (PET/CT and PET/MR). The information about the imaging modalities, applications, and reporting details are summarized in this guideline and the recommendations are composed according to the laws and regulations in our country.

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Regional FDG Lumped Constant in the Normal Human Brain

Cited by 61 publications

References 11 publications

Quantification of Task-Specific Glucose Metabolism with Constant Infusion of¹⁸F-FDG

Quantification of Task-Specific Glucose Metabolism with Constant Infusion of¹⁸F-FDG

Molecular imaging of regional brain tumor biology

TSNM Procedure Guideline for PET Brain Imaging using F-18 FDG

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Regional FDG Lumped Constant in the Normal Human Brain

Cited by 61 publications

References 11 publications

Quantification of Task-Specific Glucose Metabolism with Constant Infusion of18F-FDG

Quantification of Task-Specific Glucose Metabolism with Constant Infusion of18F-FDG

Molecular imaging of regional brain tumor biology

TSNM Procedure Guideline for PET Brain Imaging using F-18 FDG

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Product

Resources

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Quantification of Task-Specific Glucose Metabolism with Constant Infusion of¹⁸F-FDG

Quantification of Task-Specific Glucose Metabolism with Constant Infusion of¹⁸F-FDG