Regional gastric pH measurement in horses and foals

Murray, M. J.; Grodinsky, Carolyn

doi:10.1111/j.2042-3306.1989.tb05660.x

Cited by 47 publications

(34 citation statements)

References 11 publications

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“…Gastric fluid pH can be affected by stomach contents and the location in which the sample was taken [39]. A single sample aspirated from the stomach of horses can be variable and might not as accurate as continuous monitoring with a pH probe.…”

Section: Discussionmentioning

confidence: 99%

Effect of pectin, lecithin, and antacid feed supplements (Egusin®) on gastric ulcer scores, gastric fluid pH and blood gas values in horses

et al. 2014

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BackgroundThe objectives of this study were to evaluate the effects of two commercial feed supplements, Egusin 250® [E-250] and Egusin SLH® [E-SLH], on gastric ulcer scores, gastric fluid pH, and blood gas values in stall-confined horses undergoing feed-deprivation.MethodsNine Thoroughbred horses were used in a three-period crossover study. For the three treatment groups, sweet feed was mixed with E-250, E-SLH, or nothing (control group) and fed twice daily. Horses were treated for 21 days, then an additional 7 days while on an alternating feed-deprivation model to induce or worsen ulcers (period one). In periods two and three, horses (n=6) were treated for an additional 7 days after feed-deprivation. Gastroscopies were performed on day -1 (n=9), day 21 (n=9), day 28 (n=9) and day 35 (n=6). Gastric juice pH was measured and gastric ulcer scores were assigned. Venous blood gas values were also measured.ResultsGastric ulcers in control horses significantly decreased after 21 days, but there was no difference in ulcer scores when compared to the Egusin® treated horses. NG gastric ulcer scores significantly increased in E-250 and control horses on day 28 compared to day 21 as a result of intermittent feed-deprivation, but no treatment effect was observed. NG ulcer scores remained high in the control group but significantly decreased in the E-SLH- and E-250-treated horses by day 35. Gastric juice pH values were low and variable and no treatment effect was observed. Mean blood pCO2 values were significantly increased two hours after feeding in treated horses compared to controls, whereas mean blood TCO2 values increased in the 24 hour sample, but did not exceed 38 mmol/l.ConclusionsThe feed-deprivation model increased NG gastric ulcer severity in the horses. However, by day 35, Egusin® treated horses had less severe NG gastric ulcers compared to untreated control horses. After 35 days, Egusin® products tested here ameliorate the severity of gastric ulcers in stall-confined horses after feed stress.

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Section: Discussionmentioning

confidence: 99%

Effect of pectin, lecithin, and antacid feed supplements (Egusin®) on gastric ulcer scores, gastric fluid pH and blood gas values in horses

et al. 2014

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“…Mucosal defence development has not been studied in foals, per se, but mucus-bicarbonate secretion by the gastric glandular mucosa appears to be intact in very young foals (Murray and Grodinsky 1989). Mucosal defence development has not been studied in foals, per se, but mucus-bicarbonate secretion by the gastric glandular mucosa appears to be intact in very young foals (Murray and Grodinsky 1989).…”

Section: Peptic Ulcer Pathophysiologymentioning

confidence: 99%

Gastroduodenal ulceration in foals

Murray

1999

Equine Veterinary Education

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“…Indwelling pH electrodes have been placed through the biopsy channel of an endoscope and nasogastric tube (Sangiah et al . ; Murray and Grodinsky , ; Baker and Gerring ; Murray and Schusser ; Husted et al . ).…”

Section: Introductionmentioning

confidence: 98%

Gastric juicepHmeasurement in horses: Three‐quarters of a century of history!

Andrews

2015

Equine Veterinary Education

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Summary Inhibition of gastric acid and increased stomach pH>4.0 is currently accepted as the mainstay of treatment for gastric ulcers in horses. Measurement of gastric pH is complicated and requires placement of a cannula and collection of gastric juice or placement of pH electrodes in the stomach. Since the distance from the nares to the stomach is approximately 200 cm, finding a system with a pH electrode with this length is difficult, not to mention difficult to maintain. There has been a fascination with the measurement of gastric juice pH in horses that has covered three‐quarters of a century starting with a fistula model in 1933 and culminating in a recent technique described in this issue. Placement of gastric cannulas and various pH electrodes have been used to measure gastric juice pH in horses in the past and present, but the future may require more sophisticated methods as we look at the efficacy of different formulations of acid suppressive drugs for treatment of equine gastric ulcer syndrome.

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Regional gastric pH measurement in horses and foals

Cited by 47 publications

References 11 publications

Effect of pectin, lecithin, and antacid feed supplements (Egusin®) on gastric ulcer scores, gastric fluid pH and blood gas values in horses

Effect of pectin, lecithin, and antacid feed supplements (Egusin®) on gastric ulcer scores, gastric fluid pH and blood gas values in horses

Gastroduodenal ulceration in foals

Gastric juicepHmeasurement in horses: Three‐quarters of a century of history!

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