Regional Homogeneity Abnormalities Affected by Depressive Symptoms in Migraine Patients without Aura: A Resting State Study

Abstract

BackgroundBidirectional relationship between migraine and depression suggests that there might be some etiological risk factors shared. However, few studies investigated resting state abnormalities affected by depressive symptoms in migraine patients without aura (MWoA).Materials and MethodsAccording to their self-rating depression scale (SDS) score, MWoA were divided into twenty in the SDS (+) (SDS > 49) group and 20 in the SDS (−) (SDS ≤ 49) group. Regional homogeneity (ReHo) method were employed to assess local features of spontaneous brain activity between 1) all MWoA and healthy controls, 2) each subgroup and healthy controls, and 3) SDS (−) group and SDS (+) group.ResultsCompared with healthy controls, decreased ReHo in similar regions were shown in the MWoA group and subgroups. It is noteworthy that the caudate showed increased ReHo in the SDS (−) group compared with healthy controls and the SDS (+) group. Moreover, the average ReHo values of the caudate in SDS (−) group were significantly positively correlated with duration of migraine.ConclusionsOur results suggested that ReHo patterns in migraine patients may be affected by depressive symptoms and serve as a biomarker to reflect depression severity in MWoA.

A Systematic Review and Meta-Analysis of Migraine and Suicidal Ideation

“…The abnormal function of the HPA axis and other hormones can also lead to neurobiological abnormalities and structural changes in the brain [31, 42, 43]. The dysregulation of the HPA axis, changes in brain matter volume, and sensitization to high levels of stress contribute to migraine, depressive disorders, and suicidal behaviors [36, 44].…”

Discriminative Analysis of Migraine without Aura: Using Functional and Structural MRI with a Multi-Feature Classification Approach

“…Meanwhile, by employing resting-state functional MRI (rs-fMRI), a number of studies have demonstrated that migraine was associated with functional brain alterations measured by various indices, including the amplitude of low-frequency fluctuations (ALFF), regional homogeneity (ReHo), as well as functional connectivity. For example, compared with the healthy controls, migraineurs showed significant ALFF changes in the anterior cingulate cortex and prefrontal cortex [ 12 ], and ReHo changes in the prefrontal cortex, orbitofrontal cortex [ 13 ], insula [ 14 ], and cuneus [ 15 ]. Altered functional connectivity in migraineurs was identified between the dorsolateral prefrontal cortex and the dorsal anterior cingulate cortex [ 16 ], between amygdala and insula [ 17 ], and between the prefrontal and temporal regions that were within the default mode network [ 18 ].…”

Differences in regional homogeneity between patients with Crohn's disease with and without abdominal pain revealed by resting-state functional magnetic resonance imaging

“…Therefore ReHo could be a valuable method complementary to brain structure measurement and could provide a better understanding of pathophysiological changes in brain function. Many recent studies of pain-related diseases, such as irritable bowel syndrome (IBS) [19, 28], migraine [44], and complex regional pain syndrome [10], have adopted rs-fMRI to detect pathophysiological changes in certain brain regions that are related to the recognition and processing of pain signals. In recent years, there has been growing interest in the use of MRI to detect the correlation between brain activities and inflammatory visceral pain in inflammatory bowel diseases (IBD) [1-3, 6, 20, 47].…”