Regional homogeneity of adolescents with high‐functioning autism spectrum disorder and its association with symptom severity

Abstract

Background and purpose Previous studies have revealed abnormal regional homogeneity (ReHo) in individuals with autism spectrum disorder (ASD); however, there is little consistency across the findings within these studies, partly due to small sample size and great heterogeneity among participants between studies. Additionally, few studies have explored the association between ReHo aberrance and clinical symptoms in individuals with ASD. Methods Forty‐eight adolescents with high‐functioning ASD and 63 group‐matched typically developing (TD) controls received functional magnetic resonance imaging at rest. Group‐level analysis was performed to detect differences in ReHo between ASD and TD. Evaluation of symptom severity in individuals with ASD was based on the Autism Behavior Checklist (ABC). Voxel‐wise correlation analysis was undergone to examine the correlations between the symptom severity and ReHo map in individuals with ASD within brain areas with ReHo abnormalities. Results Compared with the TD controls, individuals with ASD exhibited increased ReHo in the bilateral anterior cingulate cortex, left caudate, right posterior cerebellum (cerebellar tonsil), and bilateral brainstem and decreased ReHo in the left precentral gyrus, left inferior parietal lobule, bilateral postcentral gyrus, and right anterior cerebellum (culmen). The correlation analysis indicated that the ReHo value in the brainstem was negatively associated with the ABC total scores and the scores of Relating factor, respectively. Conclusions Our findings indicated that widespread ReHo abnormalities occurred in ASD, shedding light on the underlying neurobiology of pathogenesis and symptomatology of ASD.

Decreased functional concordance in male children with autism spectrum disorder

“…Up to now, many studies have been conducted to investigate ASD in terms of different aspects of intrinsic brain activity (Guo et al, 2017; Yue et al, 2022; Zhao et al, 2022). Different methodologies may be responsible for the discrepancies and overlaps in the findings on ASD (Guo et al, 2017; Yue et al, 2022; Zhao et al, 2022).…”

“…Up to now, many studies have been conducted to investigate ASD in terms of different aspects of intrinsic brain activity (Guo et al, 2017; Yue et al, 2022; Zhao et al, 2022). Different methodologies may be responsible for the discrepancies and overlaps in the findings on ASD (Guo et al, 2017; Yue et al, 2022; Zhao et al, 2022). Hence combining multiple metrics into a comprehensive analysis is more likely to reveal differences than methods that analyze each metric separately (Muller et al, 2011).…”

Systematic review and meta-analysis: multimodal functional and anatomical neural alterations in autism spectrum disorder

“…They have been reported to have milder autism symptomatology and comparable ability to typically developing individuals (TDs) [2]. The increasing prevalence of ASD, estimated at 1 in 44 eight-year-old children, is an acknowledged public health crisis, posing a huge social and economic burden on society [3][4][5]. Unfortunately, early detection is often abstruse due to the heterogeneous symptomology and gradual course [1,5], and the underlying neuropathology remains unknown [4,6].…”

“…Accumulating evidence reveals that functional and structural brain abnormalities have been considered as a promising mechanism for the pathophysiology of ASD over the past decade [4,6]. With continuing efforts toward data-sharing and classification analyses within the field of ASD research, meta-analyses can be useful and unbiased methodological approaches that will provide convincing information [7].…”