2019
DOI: 10.1002/nbm.4142
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Regional T1 mapping of the whole cervical spinal cord using an optimized MP2RAGE sequence

Abstract: While T1 measurements present multiple challenges (robustness, acquisition time), the recently proposed MP2RAGE sequence (magnetization‐prepared two rapid acquisition gradient echoes) has opened new perspectives to characterize tissue microstructure changes occurring in a pathological or developmental context. Extensively used for brain studies, it was herein adapted to investigate the cervical spinal cord (SC) at 3 T. By integrating Bloch equations, the MP2RAGE sequence parameters were chosen to optimize SC g… Show more

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Cited by 13 publications
(25 citation statements)
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“…Another difficulty is the variable performance of the semi-automated detection and projection of the cervical SC in the compressed levels of the DCM (here performed with PropSeg 33 but also tried with DeepDeg 47 ) involving mandatory visual checking and manual correction in the postprocessing phase, which are sometimes time-consuming. Nonetheless, due to the feasibility and reproducibility of the protocol on the one hand 27 and partial correlation of the T1 values with the clinical severity on the other, this study confirms the already encouraging results of previous experiences. 18,28 Consequently, orthcoming attention to T1 mapping in DCM will have to focus on diverse key points, starting with selecting the optimal technique of measurement to standardize it.…”
Section: Potential Role In Dcmsupporting
confidence: 87%
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“…Another difficulty is the variable performance of the semi-automated detection and projection of the cervical SC in the compressed levels of the DCM (here performed with PropSeg 33 but also tried with DeepDeg 47 ) involving mandatory visual checking and manual correction in the postprocessing phase, which are sometimes time-consuming. Nonetheless, due to the feasibility and reproducibility of the protocol on the one hand 27 and partial correlation of the T1 values with the clinical severity on the other, this study confirms the already encouraging results of previous experiences. 18,28 Consequently, orthcoming attention to T1 mapping in DCM will have to focus on diverse key points, starting with selecting the optimal technique of measurement to standardize it.…”
Section: Potential Role In Dcmsupporting
confidence: 87%
“…The protocol included a 3D T2 sagittal sampling perfection with application-optimized contrasts by using different flip angle evolution (SPACE sequence; Siemens) and MP2RAGE acquisitions. The MP2RAGE 31 sequence was optimized for the SC as in Rasoanandrianina et al 27 (TE ¼ 2.48 ms, TR ¼ 4 seconds, generalized autocalibrating partially parallel acquisition ¼ 2, isotropic resolution ¼ 0.9 mm) and covered both brain and C1-C7 vertebral levels (Fig 1). This sequence provided both anatomic imaging and quantitative T1 mapping.…”
Section: Mr Imaging Protocolmentioning
confidence: 99%
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