Government and industry increasingly recognise the need to develop a more circular, resource efficient and bioeconomy that is less dependent on fossil resources. Industrial symbiosis, in this study interpreted as biowaste-to-resource innovation, is a proven strategy to limit carbon emissions whilst increasing resource-efficiency and business growth. However, the effects of governance on the implementation of industrial symbiosis have remained under-explored. Hence this study analysed the governance system for biowaste-to-resource innovation in the Humber region, UK. Key individuals within governmental and associated organisations were interviewed in 2014. The results revealed that, since 2012, public sector cuts and sub-national governance changes resulted in the removal of several organisations from the regional governance network, while capacity within the remaining organisations decreased in terms of connectivity within and between governing organisations, delivered governance activities, and crucial resources including people, money, and knowledge and skills to promote resource innovation. Formal governance to specifically monitor, plan and promote (bio)waste-to-resource innovation is now virtually absent in the Humber region. This study recommends strengthening the governance for biowaste-to-resource innovation by a) increasing integration and flexibility of the regulatory 'landscape' across governmental departments at all governance levels; b) building better connections between national and regional level governmental organisations as well as within the Humber region; and c) investing in knowledge and skills as well as operational capacity of regional governance actors. These recommendations should contribute to restoring the balance between regional capacity and the national ambitions to promote biowaste-to-resource innovation as part of the circular bioeconomy.