Regional metabolic changes of supraventricular tissue in patients with relapsing-remitting and secondary-progressive multiple sclerosis

Bogdan, A. A.; Ilves, A. G.; Kataeva, G. V.; Прахова, Л. Н.; Трофимова, Т. Н.; Stolyarov, I. D.

doi:10.17116/jnevro20151158214-17

Cited by 3 publications

(2 citation statements)

References 4 publications

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“…К примеру, в исследованиях метаболизма структурно неизмененных тканей головного мозга пациентов с рассеянным склерозом [6,7] область исследования разбивалась на 9 областей интереса, 6 из которых включали белое вещество (вокселы, включавшие конвекситальную кору, исключались из обсчета), по три области в каждой гемисфере, и 3 области включали медиальную кору суправентрикулярных пространств больших полушарий (рис. 4, слева).…”

Section: регионарный подходunclassified

Principles of Data Grouping in Assessment of Human Brain Multivoxel Spectroscopic Studies

Bogdan¹,

Khomenko²,

Катаева³

et al. 2016

Lučevaâ diagn. ter.

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Введение. Магнитно-резонансная спектроскопия -это дополнительная методика магнитно-резонансной томографии (МРТ), позволяющая прижизненно неинвазивно оценивать показатели концентрации ряда соединений в выбранном объеме ткани. Набор полученных данных зависит, прежде всего, от выбора ядра, на резонансной частоте которого будет выполняться спектроскопическое исследование (наиболее распространены 1H, 31P), диктуемый обычно аппаратными возможностями конкретного томографа. Для исследования центральной нервной системы преимущественно используют протонную (1H) спектроскопию. По принципу сбора информации метод делится на одновоксельную спектроскопию (single voxel, один выбранный объем тканивоксел) и многовоксельную спектроскопию (multi voxel, выбранный объем разбит на равные объемные единицы -вокселы), также называемую в зарубежной литературе chemical shift imaging (CSI) или magnetic spectroscopic imaging (MRSI).Стоит отметить, что для многовоксельной спектроскопии имеется ряд существенных ограничений.

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Section: регионарный подходunclassified

Principles of Data Grouping in Assessment of Human Brain Multivoxel Spectroscopic Studies

Bogdan¹,

Khomenko²,

Катаева³

et al. 2016

Lučevaâ diagn. ter.

View full text Add to dashboard Cite

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“…Однако до настоящего времени не определена референтная структура головного мозга, состояние которой мак-симально отражает развитие нейродегенеративного процесса. Применение же мультивоксельной МРС, позволяющей создать в идеале метаболическую кар-ту всего объема головного мозга, ограничено в связи с высоким уровнем зашумления сигнала [6,7] и дли-тельным временем исследования.…”

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Neuroprotection therapy of multiple sclerosis with high doses of ethylmethylhydroxypyridine succinate

Прахова

Ilves

Savintceva

et al. 2016

Z. nevrol. psikhiatr. im. S.S. Korsakova

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Studying of changes in metabolites in the brain in patients with COVID-19 according to multivoxel 1H-MRS: prospective study

Трофимова

Bogdan

Kryukova

et al. 2023

Lučevaâ diagn. ter.

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INTRODUCTION: Members of the coronavirus family can affect the human central nervous system, causing various neurological complications in patients with SARS-CoV-2. Proton magnetic resonance spectroscopy (1H-MRS) seems to be a promising technique for assessing the prognosis of persistent neurological manifestations and complications, determining the completeness of a patient’s recovery during long-term follow-up. OBJECTIVE: To study changes in the metabolites profile in the brain with relation to cognitive impairment in patients with COVID-19.MATERIALS AND METHODS: 68 patients with verified COVID-19 and neurological complaints underwent a diagnostic workup, including a psychoneurological assessment and MRI of the brain with multivoxel proton magnetic resonance spectroscopy (1H-MRS), starting in the first 2 weeks from the onset of the disease. In 11 patients, a complex examination was repeated 7–8 months after the onset of the disease. The exclusion criteria were acute severe neurological symptoms, age over 65 years, artificial lung ventilation, lung CT score III–IV, as well as information about pre-Covid neuropsychiatric disorders. As a control group, earlier collected data of 10 healthy volunteers (age 30–67 years) were taken from a local database. Statistics: Intergroup differences in the ratios of metabolites peak areas determined by the 1H-MPC method were assessed using the nonparametric Mann-Whitney test with Bonferroni’s correction for multiple comparisons. Values were considered statistically significant at p<0.05. RESULTS: According to 1H-MRS, all patients with COVID-19 showed metabolic changes in the brain: a statistically significant increase in mI/Cr in the white and gray matter and a diffuse decrease in the levels of Cho/Cr in the supraventricular white matter, even in the absence of any changes in structural MRI. DISCUSSOIN: Patients were divided into three subgroups according to the severity of neurological symptoms that arose with the onset of the coronavirus infection. The most pronounced metabolic changes were found in the group with severe neurological manifestations (NM). At follow-up, a gradual recovery of the metabolite profile was noted, but in our sample group complete normalization was not achieved within the specified time frame. CONCLUSION: The obtained data indicate metabolic changes associated with SARS-CoV-2 infection, as well as the prospects for using the 1H-MPC technique in the diagnosis of neurological complications of the new coronavirus infection, including manifestations of a psychoneurological syndrome associated with COVID-19.><0.05.RESULTS: According to 1H-MRS, all patients with COVID-19 showed metabolic changes in the brain: a statistically significant increase in mI/Cr in the white and gray matter and a diffuse decrease in the levels of Cho/Cr in the supraventricular white matter, even in the absence of any changes in structural MRI.DISCUSSOIN: Patients were divided into three subgroups according to the severity of neurological symptoms that arose with the onset of the coronavirus infection. The most pronounced metabolic changes were found in the group with severe neurological manifestations (NM). At follow-up, a gradual recovery of the metabolite profile was noted, but in our sample group complete normalization was not achieved within the specified time frame.CONCLUSION: The obtained data indicate metabolic changes associated with SARS-CoV-2 infection, as well as the prospects for using the 1H-MPC technique in the diagnosis of neurological complications of the new coronavirus infection, including manifestations of a psychoneurological syndrome associated with COVID-19.

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Regional metabolic changes of supraventricular tissue in patients with relapsing-remitting and secondary-progressive multiple sclerosis

Cited by 3 publications

References 4 publications

Principles of Data Grouping in Assessment of Human Brain Multivoxel Spectroscopic Studies

Principles of Data Grouping in Assessment of Human Brain Multivoxel Spectroscopic Studies

Neuroprotection therapy of multiple sclerosis with high doses of ethylmethylhydroxypyridine succinate

Studying of changes in metabolites in the brain in patients with COVID-19 according to multivoxel 1H-MRS: prospective study

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