Regional right ventricular function in rats: a novel magnetic resonance imaging method for measurement of right ventricular strain

Espe, Emil Knut Stenersen; Aronsen, Jan Magnus; Nordén, Einar Sjaastad; Zhang, Lili; Sjaastad, Ivar

doi:10.1152/ajpheart.00357.2019

Cited by 7 publications

(4 citation statements)

References 44 publications

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“…Pulmonary congestion resulted in higher longitudinal strain at about −10.1% and −13.8% circumferentially. Global strain rate showed a similar trend with circumferential and longitudinal strain rates of −4 s −1 and −4.7 s −1 , respectively [93].…”

Section: Small Animal Modelssupporting

confidence: 60%

Soft-Tissue Material Properties and Mechanogenetics during Cardiovascular Development

Siddiqui

Dogru

Lashkarinia

et al. 2022

JCDD

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During embryonic development, changes in the cardiovascular microstructure and material properties are essential for an integrated biomechanical understanding. This knowledge also enables realistic predictive computational tools, specifically targeting the formation of congenital heart defects. Material characterization of cardiovascular embryonic tissue at consequent embryonic stages is critical to understand growth, remodeling, and hemodynamic functions. Two biomechanical loading modes, which are wall shear stress and blood pressure, are associated with distinct molecular pathways and govern vascular morphology through microstructural remodeling. Dynamic embryonic tissues have complex signaling networks integrated with mechanical factors such as stress, strain, and stiffness. While the multiscale interplay between the mechanical loading modes and microstructural changes has been studied in animal models, mechanical characterization of early embryonic cardiovascular tissue is challenging due to the miniature sample sizes and active/passive vascular components. Accordingly, this comparative review focuses on the embryonic material characterization of developing cardiovascular systems and attempts to classify it for different species and embryonic timepoints. Key cardiovascular components including the great vessels, ventricles, heart valves, and the umbilical cord arteries are covered. A state-of-the-art review of experimental techniques for embryonic material characterization is provided along with the two novel methods developed to measure the residual and von Mises stress distributions in avian embryonic vessels noninvasively, for the first time in the literature. As attempted in this review, the compilation of embryonic mechanical properties will also contribute to our understanding of the mature cardiovascular system and possibly lead to new microstructural and genetic interventions to correct abnormal development.

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Section: Small Animal Modelssupporting

confidence: 60%

Soft-Tissue Material Properties and Mechanogenetics during Cardiovascular Development

Siddiqui

Dogru

Lashkarinia

et al. 2022

JCDD

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“…Cine segmentation was performed using Segment v3.0 R7820 (http://segment.heiberg.se). 13 Tissue phase mapping (TPM) slices were acquired, one mid‐ventricular short axis and one long axis, allowing calculation of systolic and diastolic strains and strain rates as previously described 14,15 . Combination of TPM with data from echocardiography allowed calculation of the ratio of early mitral inflow velocity to the global diastolic strain rate (E/e'SR).…”

Section: Methodsmentioning

confidence: 99%

“…13 Tissue phase mapping (TPM) slices were acquired, one mid-ventricular short axis and one long axis, allowing calculation of systolic and diastolic strains and strain rates as previously described. 14,15 Combination of TPM with data from echocardiography allowed calculation of the ratio of early mitral inflow velocity to the global Sacubitril/valsartan ameliorates cardiac hypertrophy and diastolic dysfunction in cardiac pressure overload diastolic strain rate (E/e'SR). Data were analysed in a blinded fashion using MATLAB (The MathWorks Inc., USA).…”

Section: Magnetic Resonance Imagingmentioning

confidence: 99%

Sacubitril/valsartan ameliorates cardiac hypertrophy and preserves diastolic function in cardiac pressure overload

et al. 2021

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Aims Sacubitril/valsartan (sac/val) has shown superior effect compared with blockade of the renin-angiotensin-aldosterone system in heart failure with reduced ejection fraction. We aimed to investigate effects of sac/val compared with valsartan in a pressure overload model of heart failure with preserved ejection fraction (HFpEF). Methods and results Sprague-Dawley rats underwent aortic banding or sham (n = 16) surgery and were randomized to sac/val (n = 28), valsartan (n = 29), or vehicle (n = 26) treatment for 8 weeks. Sac/val reduced left ventricular weight by 11% compared with vehicle (P = 0.01) and 9% compared with valsartan alone (P = 0.04). Only valsartan reduced blood pressure compared with sham (P = 0.02). Longitudinal early diastolic strain rate was preserved in sac/val compared with sham, while it was reduced by 23% in vehicle (P = 0.03) and 24% in valsartan (P = 0.02). Diastolic dysfunction, measured by E/e'SR, increased by 68% in vehicle (P < 0.01) and 80% in valsartan alone (P < 0.001), while sac/val showed no increase. Neither sac/val nor valsartan prevented interstitial fibrosis. Although ejection fraction was preserved, we observed mild systolic dysfunction, with vehicle showing a 28% decrease in longitudinal strain (P < 0.01). Neither sac/val nor valsartan treatment improved this dysfunction. Conclusions In a model of HFpEF induced by cardiac pressure overload, sac/val reduced hypertrophy compared with valsartan alone and ameliorated diastolic dysfunction. These effects were independent of blood pressure. Early systolic dysfunction was not affected, supporting the notion that sac/val has the largest potential in conditions characterized by reduced ejection fraction. Observed anti-hypertrophic effects in preserved ejection fraction implicate potential benefit of sac/val in the clinical setting of hypertrophic remodelling and impaired diastolic function.

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“…Previous studies have shown that cardiac dysfunction reduces LS [13]. MR myocardial strain analysis using tagging and phase contrast has also been used to evaluate local myocardial wall motion in rodents [14,15]. However, these methods have a problem in that the examination time is extended since it is necessary to acquire a tagging image and a phase-contrast image.…”

Section: Introductionmentioning

confidence: 99%

Application of Magnetic Resonance Strain Analysis Using Feature Tracking in a Myocardial Infarction Model

et al. 2023

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This study validates the usefulness of myocardial strain analysis with cardiac cine magnetic resonance imaging (MRI) by evaluating the changes in the cardiac function and myocardial strain values longitudinally in a myocardial disease model. Six eight-week-old male Wistar rats were used as a model of myocardial infarction (MI). Cine images were taken in the short axis, two-chamber view longitudinal axis, and four-chamber view longitudinal axis directions in rats 3 and 9 days after MI and in control rats, with preclinical 7-T MRI. The control images and the images on days 3 and 9 were evaluated by measuring the ventricular ejection fraction (EF) and the strain values in the circumferential (CS), radial (RS), and longitudinal directions (LS). The CS decreased significantly 3 days after MI, but there was no difference between the images on days 3 and 9. The two-chamber view LS was −9.7 ± 2.1% at 3 days and −13.9 ± 1.4% at 9 days after MI. The four-chamber view LS was −9.9 ± 1.5% at 3 days and −11.9 ± 1.3% at 9 days after MI. Both the two- and four-chamber LS values were significantly decreased 3 days after MI. Myocardial strain analysis is, therefore, useful for assessing the pathophysiology of MI.

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Regional right ventricular function in rats: a novel magnetic resonance imaging method for measurement of right ventricular strain

Cited by 7 publications

References 44 publications

Soft-Tissue Material Properties and Mechanogenetics during Cardiovascular Development

Soft-Tissue Material Properties and Mechanogenetics during Cardiovascular Development

Sacubitril/valsartan ameliorates cardiac hypertrophy and preserves diastolic function in cardiac pressure overload

Application of Magnetic Resonance Strain Analysis Using Feature Tracking in a Myocardial Infarction Model

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